JP2023553811A5 - - Google Patents
Info
- Publication number
- JP2023553811A5 JP2023553811A5 JP2023531000A JP2023531000A JP2023553811A5 JP 2023553811 A5 JP2023553811 A5 JP 2023553811A5 JP 2023531000 A JP2023531000 A JP 2023531000A JP 2023531000 A JP2023531000 A JP 2023531000A JP 2023553811 A5 JP2023553811 A5 JP 2023553811A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- groups
- formula
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063117763P | 2020-11-24 | 2020-11-24 | |
| US63/117,763 | 2020-11-24 | ||
| PCT/US2021/060620 WO2022115477A1 (en) | 2020-11-24 | 2021-11-23 | Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023553811A JP2023553811A (ja) | 2023-12-26 |
| JP2023553811A5 true JP2023553811A5 (https=) | 2024-12-13 |
Family
ID=78957622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023531000A Pending JP2023553811A (ja) | 2020-11-24 | 2021-11-23 | Ｂｃｌ－ｘｌ阻害剤抗体－薬物コンジュゲートおよびその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240269304A1 (https=) |
| EP (1) | EP4251209A1 (https=) |
| JP (1) | JP2023553811A (https=) |
| KR (1) | KR20230143605A (https=) |
| CN (1) | CN116761635A (https=) |
| AU (1) | AU2021386367A1 (https=) |
| CA (1) | CA3198996A1 (https=) |
| IL (1) | IL303048A (https=) |
| WO (1) | WO2022115477A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119562832A (zh) * | 2022-05-20 | 2025-03-04 | 诺华股份有限公司 | Met bcl-xl抑制剂抗体-药物缀合物及其使用方法 |
| AU2023271885A1 (en) * | 2022-05-20 | 2024-12-12 | Les Laboratoires Servier | Epha2 bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
| WO2024083162A1 (en) * | 2022-10-19 | 2024-04-25 | Multitude Therapeutics Inc. | Antibodies, antibody-drug conjugates, preparations and uses thereof |
| IL326476A (en) * | 2023-08-23 | 2026-04-01 | Granular Therapeutics Ltd | Anti-CD203C antibody bracelets and their use |
| AR134424A1 (es) * | 2023-11-22 | 2026-01-14 | Novartis Ag | Conjugados de anticuerpo anti-cd7-fármaco y métodos de uso de los mismos |
| WO2025155943A1 (en) * | 2024-01-18 | 2025-07-24 | Joinn Biologics Us Inc. | Immunoconjugates comprising camptothecin analogs and methods of use thereof |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| EP1958962A3 (en) | 1997-06-12 | 2013-05-01 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| WO2003059354A2 (en) * | 2001-12-21 | 2003-07-24 | Bayer Pharmaceuticals Corporation | Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives |
| CA2473144C (en) | 2002-02-05 | 2013-05-28 | Genentech, Inc. | Protein purification |
| ZA200503075B (en) | 2002-11-07 | 2006-09-27 | Immunogen Inc | Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same |
| KR101512203B1 (ko) | 2006-11-10 | 2015-04-15 | 가부시키가이샤 리부텍쿠 | ｉｎ ｖｉｖｏ 에서 항종양 활성을 갖는 항인간 Ｄｌｋ－１ 항체 |
| WO2009020603A2 (en) * | 2007-08-08 | 2009-02-12 | The Scripps Research Institute | Upp amphiphilic alpha-helix mimetics |
| NZ593536A (en) | 2008-12-19 | 2013-07-26 | Genentech Inc | Quinoline derivatives and methods of use |
| WO2010080503A1 (en) | 2008-12-19 | 2010-07-15 | Genentech, Inc. | Heterocyclic compounds and methods of use |
| EP2711018A1 (en) | 2009-06-22 | 2014-03-26 | MedImmune, LLC | Engineered Fc regions for site-specific conjugation |
| CN102844045A (zh) | 2010-02-08 | 2012-12-26 | 艾更斯司股份有限公司 | 结合于161p2f10b蛋白的抗体药物偶联物(adc) |
| WO2012147713A1 (ja) | 2011-04-25 | 2012-11-01 | 第一三共株式会社 | 抗ｂ７－ｈ３抗体 |
| KR101972446B1 (ko) | 2011-05-27 | 2019-04-25 | 글락소 그룹 리미티드 | Ｂｃｍａ（ｃｄ２６９／ｔｎｆｒｓｆ１７）결합 단백질 |
| TWI571466B (zh) | 2011-10-14 | 2017-02-21 | 艾伯維有限公司 | 用於治療癌症及免疫與自體免疫疾病之細胞凋亡誘發劑 |
| TWI561521B (en) | 2011-10-14 | 2016-12-11 | Abbvie Inc | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| EP3539985A1 (en) | 2012-02-24 | 2019-09-18 | AbbVie Stemcentrx LLC | Anti sez6 antibodies and methods of use |
| EP2953976B1 (en) | 2013-02-08 | 2021-03-24 | Novartis Ag | Specific sites for modifying antibodies to make immunoconjugates |
| FR3015483B1 (fr) | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP2017509337A (ja) | 2014-03-12 | 2017-04-06 | ノバルティス アーゲー | イムノコンジュゲートを作製する抗体を修飾するための特定部位 |
| CN111620861A (zh) | 2014-12-09 | 2020-09-04 | 艾伯维公司 | 具有低细胞渗透性的bcl-xl抑制性化合物以及包括它的抗体药物缀合物 |
| CN107207553A (zh) | 2014-12-09 | 2017-09-26 | 艾伯维公司 | Bcl‑xl抑制性化合物和包括其的抗体药物缀合物 |
| CN113209306A (zh) | 2014-12-09 | 2021-08-06 | 艾伯维公司 | 具有细胞渗透性的bcl-xl抑制剂的抗体药物缀合物 |
| BR112017023862A2 (pt) | 2015-05-04 | 2018-07-17 | Cytomx Therapeutics Inc | anticorpos anti-cd71, anticorpos anti-cd71 ativáveis, e métodos de uso destes |
| US20190194315A1 (en) | 2015-06-17 | 2019-06-27 | Novartis Ag | Antibody drug conjugates |
| AU2017279550A1 (en) | 2016-06-08 | 2019-01-03 | Abbvie Inc. | Anti-B7-H3 antibodies and antibody drug conjugates |
| BR112018075639A2 (pt) | 2016-06-08 | 2019-04-09 | Abbvie Inc. | conjugados de anticorpo fármaco anti-egfr |
| AU2017277534A1 (en) | 2016-06-08 | 2019-01-03 | Abbvie Inc. | Anti-EGFR antibody drug conjugates |
| RU2018147224A (ru) | 2016-06-08 | 2020-07-14 | Эббви Инк. | Конъюгаты антитела к egfr и лекарственного средства |
| NZ752984A (en) | 2016-11-22 | 2026-03-27 | Nat Univ Singapore | Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies |
| KR20220024106A (ko) | 2019-05-20 | 2022-03-03 | 노파르티스 아게 | Mcl-1 억제제 항체-약물 접합체 및 사용 방법 |
| AR119493A1 (es) * | 2019-07-29 | 2021-12-22 | Servier Lab | Derivados de 3,6-diamino-piridazin-3-ilo, composiciones farmacéuticas que los contienen y sus usos como agentes proapoptóticos |
| AR119494A1 (es) * | 2019-07-29 | 2021-12-22 | Servier Lab | DERIVADOS DE 6,7-DIHIDRO-5H-PIRIDO[2,3-c]PIRIDAZIN-8-ILO, COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN Y SUS USOS COMO AGENTES PROAPOPTÓTICOS |
-
2021
- 2021-11-23 AU AU2021386367A patent/AU2021386367A1/en active Pending
- 2021-11-23 CA CA3198996A patent/CA3198996A1/en active Pending
- 2021-11-23 CN CN202180091693.8A patent/CN116761635A/zh active Pending
- 2021-11-23 JP JP2023531000A patent/JP2023553811A/ja active Pending
- 2021-11-23 EP EP21827768.9A patent/EP4251209A1/en active Pending
- 2021-11-23 WO PCT/US2021/060620 patent/WO2022115477A1/en not_active Ceased
- 2021-11-23 US US18/038,435 patent/US20240269304A1/en active Pending
- 2021-11-23 IL IL303048A patent/IL303048A/en unknown
- 2021-11-23 KR KR1020237021029A patent/KR20230143605A/ko active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023553811A5 (https=) | ||
| JP7431261B2 (ja) | 自己安定化リンカー結合体 | |
| ES2941768T3 (es) | Compuestos de 2H-pirazolo[4,3-d]pirimidina como agonistas del receptor 7 tipo toll (TLR7) y métodos y usos para los mismos | |
| AU2017203928B2 (en) | Novel binder-drug conjugates (ADCs) and their use | |
| JP2025510629A (ja) | カンプトテシンコンジュゲート | |
| JP2022532918A5 (https=) | ||
| EP4132588A1 (en) | Charge variant linkers | |
| US20240261422A1 (en) | Anthracycline antibody conjugates | |
| JP2026510354A (ja) | ｐａｎＲＡＳ阻害剤抗体薬物コンジュゲート及びその使用方法 | |
| KR20160098257A (ko) | 세포독성 펩티드 및 그의 접합체 | |
| EP4277904A1 (en) | Immunomodulatory antibody-drug conjugates | |
| AU2023320054A1 (en) | Immunostimulatory anti-pd-l1-drug conjugates | |
| RU2024138377A (ru) | Конъюгаты антитело-лекарственное средство, являющиеся ингибиторами met bcl-xl, и способы их применения | |
| RU2025127473A (ru) | Конъюгаты антитела и лекарственного средства, содержащие ингибитор panras, и способы их применения | |
| RU2024138371A (ru) | Конъюгаты антитело-лекарственное средство, являющиеся ингибиторами epha2 bcl-xl, и способы их применения | |
| RU2021137408A (ru) | Конъюгаты антитело-лекарственное средство ингибитора MCL-1 и способы их применения | |
| RU2021137422A (ru) | Конъюгаты антитело-лекарственное средство ингибитора mcl-1 и способы их применения | |
| TW202506691A (zh) | Ｓｔｉｎｇ促效劑化合物及其結合物 | |
| WO2025090774A1 (en) | Chemotherapeutic compounds and methods of use | |
| CN121194800A (zh) | 接头化合物和配体-药物缀合物及其制备方法和用途 | |
| HK40119840A (zh) | 免疫刺激抗pd-l1-药物偶联物 | |
| HK40106962A (zh) | 蒽环霉素抗体结合物 | |
| BR122023026165A2 (pt) | Conjugados de peptídeo de camptotecina e usos dos mesmos |