JP2023552793A5 - - Google Patents

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Publication number
JP2023552793A5
JP2023552793A5 JP2023534685A JP2023534685A JP2023552793A5 JP 2023552793 A5 JP2023552793 A5 JP 2023552793A5 JP 2023534685 A JP2023534685 A JP 2023534685A JP 2023534685 A JP2023534685 A JP 2023534685A JP 2023552793 A5 JP2023552793 A5 JP 2023552793A5
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JP
Japan
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substituted
unsubstituted
substituents
ome
pharmaceutically acceptable
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Pending
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JP2023534685A
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English (en)
Japanese (ja)
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JP2023552793A (ja
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Application filed filed Critical
Priority claimed from PCT/EP2021/084673 external-priority patent/WO2022122773A1/en
Publication of JP2023552793A publication Critical patent/JP2023552793A/ja
Publication of JP2023552793A5 publication Critical patent/JP2023552793A5/ja
Pending legal-status Critical Current

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JP2023534685A 2020-12-08 2021-12-07 心不全の処置のための、ｒｘｆｐ１モデュレーターとしての４－（２－フルオロ－４－メトキシ－５－３－（（（１－メチルシクロブチル）メチル）カルバモイル）ビシクロ［２．２．１］ヘプタン－２－イル）カルバモイル）フェノキシ）－１－メチルシクロヘキサン－１－カルボン酸誘導体及び類似化合物 Pending JP2023552793A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063122690P 2020-12-08 2020-12-08
US63/122,690 2020-12-08
PCT/EP2021/084673 WO2022122773A1 (en) 2020-12-08 2021-12-07 4-(2-fluoro-4-methoxy-5-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid derivatives and similar compounds as rxfp1 modulators for the treatment of heart failure

Publications (2)

Publication Number Publication Date
JP2023552793A JP2023552793A (ja) 2023-12-19
JP2023552793A5 true JP2023552793A5 (https=) 2024-12-10

Family

ID=78916968

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023534685A Pending JP2023552793A (ja) 2020-12-08 2021-12-07 心不全の処置のための、ｒｘｆｐ１モデュレーターとしての４－（２－フルオロ－４－メトキシ－５－３－（（（１－メチルシクロブチル）メチル）カルバモイル）ビシクロ［２．２．１］ヘプタン－２－イル）カルバモイル）フェノキシ）－１－メチルシクロヘキサン－１－カルボン酸誘導体及び類似化合物

Country Status (19)

Country Link
US (2) US11667602B2 (https=)
EP (1) EP4259605A1 (https=)
JP (1) JP2023552793A (https=)
KR (1) KR20230118142A (https=)
CN (1) CN116547270A (https=)
AR (1) AR124193A1 (https=)
AU (1) AU2021395353B2 (https=)
CA (1) CA3203024A1 (https=)
CL (1) CL2023001572A1 (https=)
CO (1) CO2023008303A2 (https=)
CR (1) CR20230296A (https=)
DO (1) DOP2023000111A (https=)
EC (1) ECSP23050133A (https=)
IL (1) IL303220A (https=)
MX (1) MX2023006178A (https=)
PE (1) PE20240655A1 (https=)
TW (1) TW202237559A (https=)
UY (1) UY39559A (https=)
WO (1) WO2022122773A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250221966A1 (en) * 2021-10-29 2025-07-10 Bristol-Myers Squibb Company Rxfp1 agonists
US20250268903A1 (en) * 2021-10-29 2025-08-28 Bristol-Myers Squibb Company Rxfp1 agonists
KR20240095290A (ko) * 2021-10-29 2024-06-25 브리스톨-마이어스 스큅 컴퍼니 심부전의 치료를 위한 rxfp1 조정제
ES3062200T3 (en) * 2021-10-29 2026-04-09 Bristol Myers Squibb Co Rxfp1 agonists
US20260069558A1 (en) * 2022-06-07 2026-03-12 Astrazeneca Ab Rxfp1 modulators for treating resistant hypertension or heart failure with pulmonary hypertension
CN119630638A (zh) * 2022-06-07 2025-03-14 阿斯利康(瑞典)有限公司 Rxfp1调节剂的固体形式
US20260069559A1 (en) * 2022-06-07 2026-03-12 Astrazeneca Ab Combinations of rxfp1 modulators and sglt2 inhibitors
CN121605099A (zh) * 2023-08-10 2026-03-03 深圳信立泰药业股份有限公司 一种rxfp1受体调节剂及其制备方法和医药用途
CN121729228A (zh) 2023-08-15 2026-03-24 阿斯利康(瑞典)有限公司 在治疗心力衰竭中使用的化合物azd5462
TW202530177A (zh) * 2023-10-13 2025-08-01 大陸商江蘇恆瑞醫藥股份有限公司 醯胺取代的環烷基類化合物、其製備方法及其在醫藥上的應用
WO2025106780A1 (en) 2023-11-17 2025-05-22 Eli Lilly And Company Rxfp1 receptor agonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223534A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Benzofuuranyl/benofuranylaklyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
WO2004041795A1 (en) * 2002-10-30 2004-05-21 Guilford Pharmaceuticals Inc. Novel inhibitors of dipeptidyl peptidase iv
US9452973B2 (en) * 2012-05-04 2016-09-27 The United States Of America, As Represented By The Secretary Department Of Health And Human Services Modulators of the relaxin receptor 1

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