AU2021395353B2 - 4-(2-fluoro-4-methoxy-5-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid derivatives and similar compounds as rxfp1 modulators for the treatment of heart failure - Google Patents

4-(2-fluoro-4-methoxy-5-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid derivatives and similar compounds as rxfp1 modulators for the treatment of heart failure Download PDF

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AU2021395353B2
AU2021395353B2 AU2021395353A AU2021395353A AU2021395353B2 AU 2021395353 B2 AU2021395353 B2 AU 2021395353B2 AU 2021395353 A AU2021395353 A AU 2021395353A AU 2021395353 A AU2021395353 A AU 2021395353A AU 2021395353 B2 AU2021395353 B2 AU 2021395353B2
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carbamoyl
bicyclo
fluoro
carboxylic acid
methoxy
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AU2021395353A9 (en
AU2021395353A1 (en
Inventor
Giulia BERGONZINI
Hans Fredrik BERGSTRÖM
Stig Jonas BOSTRÖM
Ryuichi FUCHIGAMI
Masakazu Fujio
Henrik GRADÉN
Kenneth Lars Granberg
Yasuki NIWA
Shigeki Sakamaki
Lars Johan Andreas Ulander
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Tanabe Pharma Corp
AstraZeneca AB
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Mitsubishi Tanabe Pharma Corp
AstraZeneca AB
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    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/275—Nitriles; Isonitriles
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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AU2021395353A 2020-12-08 2021-12-07 4-(2-fluoro-4-methoxy-5-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid derivatives and similar compounds as rxfp1 modulators for the treatment of heart failure Active AU2021395353B2 (en)

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US202063122690P 2020-12-08 2020-12-08
US63/122,690 2020-12-08
PCT/EP2021/084673 WO2022122773A1 (en) 2020-12-08 2021-12-07 4-(2-fluoro-4-methoxy-5-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid derivatives and similar compounds as rxfp1 modulators for the treatment of heart failure

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AU2021395353A1 AU2021395353A1 (en) 2023-07-13
AU2021395353A9 AU2021395353A9 (en) 2024-02-08
AU2021395353B2 true AU2021395353B2 (en) 2024-08-29

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US20250221966A1 (en) * 2021-10-29 2025-07-10 Bristol-Myers Squibb Company Rxfp1 agonists
US20250268903A1 (en) * 2021-10-29 2025-08-28 Bristol-Myers Squibb Company Rxfp1 agonists
KR20240095290A (ko) * 2021-10-29 2024-06-25 브리스톨-마이어스 스큅 컴퍼니 심부전의 치료를 위한 rxfp1 조정제
ES3062200T3 (en) * 2021-10-29 2026-04-09 Bristol Myers Squibb Co Rxfp1 agonists
US20260069558A1 (en) * 2022-06-07 2026-03-12 Astrazeneca Ab Rxfp1 modulators for treating resistant hypertension or heart failure with pulmonary hypertension
CN119630638A (zh) * 2022-06-07 2025-03-14 阿斯利康(瑞典)有限公司 Rxfp1调节剂的固体形式
US20260069559A1 (en) * 2022-06-07 2026-03-12 Astrazeneca Ab Combinations of rxfp1 modulators and sglt2 inhibitors
CN121605099A (zh) * 2023-08-10 2026-03-03 深圳信立泰药业股份有限公司 一种rxfp1受体调节剂及其制备方法和医药用途
CN121729228A (zh) 2023-08-15 2026-03-24 阿斯利康(瑞典)有限公司 在治疗心力衰竭中使用的化合物azd5462
TW202530177A (zh) * 2023-10-13 2025-08-01 大陸商江蘇恆瑞醫藥股份有限公司 醯胺取代的環烷基類化合物、其製備方法及其在醫藥上的應用
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