JP2023551110A - Ｉｌ‐１７モジュレーターとしてのジシクロプロピルメチル誘導体 - Google Patents

Ｉｌ‐１７モジュレーターとしてのジシクロプロピルメチル誘導体 Download PDF

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Publication number
JP2023551110A
JP2023551110A JP2023527430A JP2023527430A JP2023551110A JP 2023551110 A JP2023551110 A JP 2023551110A JP 2023527430 A JP2023527430 A JP 2023527430A JP 2023527430 A JP2023527430 A JP 2023527430A JP 2023551110 A JP2023551110 A JP 2023551110A
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JP
Japan
Prior art keywords
formula
compound
alkyl
pharmaceutically acceptable
oxide
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2023527430A
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English (en)
Japanese (ja)
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JP2023551110A5 (https=
Inventor
リチャード フロスト、ジェイムズ
ウィリアム ハスレット、グレゴリー
トーマス レウベルソン、ジェイムズ
Original Assignee
ユーシービー バイオファルマ エスアールエル
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Priority claimed from GBGB2017642.6A external-priority patent/GB202017642D0/en
Priority claimed from GBGB2108945.3A external-priority patent/GB202108945D0/en
Application filed by ユーシービー バイオファルマ エスアールエル filed Critical ユーシービー バイオファルマ エスアールエル
Publication of JP2023551110A publication Critical patent/JP2023551110A/ja
Publication of JP2023551110A5 publication Critical patent/JP2023551110A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2023527430A 2020-11-09 2021-11-01 Ｉｌ‐１７モジュレーターとしてのジシクロプロピルメチル誘導体 Pending JP2023551110A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB2017642.6A GB202017642D0 (en) 2020-11-09 2020-11-09 Therapeputic agents
GB2017642.6 2020-11-09
GB2108945.3 2021-06-22
GBGB2108945.3A GB202108945D0 (en) 2021-06-22 2021-06-22 Therapeutic agents
PCT/EP2021/080251 WO2022096412A1 (en) 2020-11-09 2021-11-01 Dicyclopropylmethyl derivatives as il-17 modulators

Publications (2)

Publication Number Publication Date
JP2023551110A true JP2023551110A (ja) 2023-12-07
JP2023551110A5 JP2023551110A5 (https=) 2024-10-15

Family

ID=78536191

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023527430A Pending JP2023551110A (ja) 2020-11-09 2021-11-01 Ｉｌ‐１７モジュレーターとしてのジシクロプロピルメチル誘導体

Country Status (6)

Country Link
US (1) US20230399328A1 (https=)
EP (1) EP4240742A1 (https=)
JP (1) JP2023551110A (https=)
CN (1) CN116406267A (https=)
CA (1) CA3199816A1 (https=)
WO (1) WO2022096412A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR126255A1 (es) 2021-07-01 2023-10-04 UCB Biopharma SRL Derivados de imidazotriazina como moduladores de il-17
WO2023025783A1 (en) 2021-08-23 2023-03-02 Leo Pharma A/S Small molecule modulators of il-17
WO2023111181A1 (en) 2021-12-16 2023-06-22 Leo Pharma A/S Small molecule modulators of il-17
WO2023166172A1 (en) 2022-03-04 2023-09-07 Leo Pharma A/S Small molecule modulators of il-17
GB202210731D0 (en) 2022-07-22 2022-09-07 UCB Biopharma SRL Therapeutic agents
TW202430165A (zh) 2022-12-02 2024-08-01 丹麥商理奧藥品公司 Il-17之小分子調節劑

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019138017A1 (en) * 2018-01-15 2019-07-18 Ucb Biopharma Sprl Fused imidazole derivatives as il-17 modulators
WO2020127685A1 (en) * 2018-12-19 2020-06-25 Leo Pharma A/S Amino-acid anilides as small molecule modulators of il-17

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2242504B1 (en) 2008-01-09 2021-07-14 The Schepens Eye Research Institute, Inc. Therapeutic compositions for treatment of ocular inflammatory disorders
EP2809660B1 (en) 2012-02-02 2016-01-20 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating il-17
WO2014066726A2 (en) 2012-10-26 2014-05-01 Ensemble Therapeutics Corporation Compounds for modulating il-17
GB201709456D0 (en) 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents
CN110511213B (zh) 2018-05-22 2021-10-19 成都先导药物开发股份有限公司 一种免疫调节剂
EP3820567A1 (en) 2018-07-12 2021-05-19 UCB Biopharma SRL Spirocyclic indane analogues as il-17 modulators
GB201820165D0 (en) 2018-12-11 2019-01-23 Ucb Biopharma Sprl Therapeutic agents
GB201820166D0 (en) 2018-12-11 2019-01-23 Ucb Biopharma Sprl Therapeutic agents
TWI752400B (zh) 2019-01-07 2022-01-11 美商美國禮來大藥廠 Il-17a抑制劑
US20220162191A1 (en) 2019-03-08 2022-05-26 Leo Pharma A/S Small molecule modulators of il-17
GB201909191D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
GB201909190D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
GB201909194D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019138017A1 (en) * 2018-01-15 2019-07-18 Ucb Biopharma Sprl Fused imidazole derivatives as il-17 modulators
WO2020127685A1 (en) * 2018-12-19 2020-06-25 Leo Pharma A/S Amino-acid anilides as small molecule modulators of il-17

Also Published As

Publication number Publication date
WO2022096412A1 (en) 2022-05-12
CN116406267A (zh) 2023-07-07
EP4240742A1 (en) 2023-09-13
CA3199816A1 (en) 2022-05-12
US20230399328A1 (en) 2023-12-14

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