CN116406267A - 作为il-17调节剂的二环丙基甲基衍生物 - Google Patents

作为il-17调节剂的二环丙基甲基衍生物 Download PDF

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Publication number
CN116406267A
CN116406267A CN202180075513.7A CN202180075513A CN116406267A CN 116406267 A CN116406267 A CN 116406267A CN 202180075513 A CN202180075513 A CN 202180075513A CN 116406267 A CN116406267 A CN 116406267A
Authority
CN
China
Prior art keywords
compound
formula
pharmaceutically acceptable
treatment
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180075513.7A
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English (en)
Chinese (zh)
Inventor
J·R·福斯特
G·W·哈斯利特
J·T·鲁伯森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Biopharma SRL
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB2017642.6A external-priority patent/GB202017642D0/en
Priority claimed from GBGB2108945.3A external-priority patent/GB202108945D0/en
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of CN116406267A publication Critical patent/CN116406267A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202180075513.7A 2020-11-09 2021-11-01 作为il-17调节剂的二环丙基甲基衍生物 Pending CN116406267A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB2017642.6A GB202017642D0 (en) 2020-11-09 2020-11-09 Therapeputic agents
GB2017642.6 2020-11-09
GB2108945.3 2021-06-22
GBGB2108945.3A GB202108945D0 (en) 2021-06-22 2021-06-22 Therapeutic agents
PCT/EP2021/080251 WO2022096412A1 (en) 2020-11-09 2021-11-01 Dicyclopropylmethyl derivatives as il-17 modulators

Publications (1)

Publication Number Publication Date
CN116406267A true CN116406267A (zh) 2023-07-07

Family

ID=78536191

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180075513.7A Pending CN116406267A (zh) 2020-11-09 2021-11-01 作为il-17调节剂的二环丙基甲基衍生物

Country Status (6)

Country Link
US (1) US20230399328A1 (https=)
EP (1) EP4240742A1 (https=)
JP (1) JP2023551110A (https=)
CN (1) CN116406267A (https=)
CA (1) CA3199816A1 (https=)
WO (1) WO2022096412A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR126255A1 (es) 2021-07-01 2023-10-04 UCB Biopharma SRL Derivados de imidazotriazina como moduladores de il-17
WO2023025783A1 (en) 2021-08-23 2023-03-02 Leo Pharma A/S Small molecule modulators of il-17
WO2023111181A1 (en) 2021-12-16 2023-06-22 Leo Pharma A/S Small molecule modulators of il-17
WO2023166172A1 (en) 2022-03-04 2023-09-07 Leo Pharma A/S Small molecule modulators of il-17
GB202210731D0 (en) 2022-07-22 2022-09-07 UCB Biopharma SRL Therapeutic agents
TW202430165A (zh) 2022-12-02 2024-08-01 丹麥商理奧藥品公司 Il-17之小分子調節劑

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2242504B1 (en) 2008-01-09 2021-07-14 The Schepens Eye Research Institute, Inc. Therapeutic compositions for treatment of ocular inflammatory disorders
EP2809660B1 (en) 2012-02-02 2016-01-20 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating il-17
WO2014066726A2 (en) 2012-10-26 2014-05-01 Ensemble Therapeutics Corporation Compounds for modulating il-17
GB201709456D0 (en) 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents
US11472794B2 (en) * 2018-01-15 2022-10-18 UCB Biopharma SRL Fused imidazole derivatives as IL-17 modulators
CN110511213B (zh) 2018-05-22 2021-10-19 成都先导药物开发股份有限公司 一种免疫调节剂
EP3820567A1 (en) 2018-07-12 2021-05-19 UCB Biopharma SRL Spirocyclic indane analogues as il-17 modulators
GB201820165D0 (en) 2018-12-11 2019-01-23 Ucb Biopharma Sprl Therapeutic agents
GB201820166D0 (en) 2018-12-11 2019-01-23 Ucb Biopharma Sprl Therapeutic agents
SG11202106444WA (en) * 2018-12-19 2021-07-29 Leo Pharma As Amino-acid anilides as small molecule modulators of il-17
TWI752400B (zh) 2019-01-07 2022-01-11 美商美國禮來大藥廠 Il-17a抑制劑
US20220162191A1 (en) 2019-03-08 2022-05-26 Leo Pharma A/S Small molecule modulators of il-17
GB201909191D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
GB201909190D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
GB201909194D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents

Also Published As

Publication number Publication date
WO2022096412A1 (en) 2022-05-12
EP4240742A1 (en) 2023-09-13
CA3199816A1 (en) 2022-05-12
JP2023551110A (ja) 2023-12-07
US20230399328A1 (en) 2023-12-14

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Application publication date: 20230707

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