CA3199816A1 - Dicyclopropylmethyl derivatives as il-17 modulators - Google Patents

Dicyclopropylmethyl derivatives as il-17 modulators

Info

Publication number
CA3199816A1
CA3199816A1 CA3199816A CA3199816A CA3199816A1 CA 3199816 A1 CA3199816 A1 CA 3199816A1 CA 3199816 A CA3199816 A CA 3199816A CA 3199816 A CA3199816 A CA 3199816A CA 3199816 A1 CA3199816 A1 CA 3199816A1
Authority
CA
Canada
Prior art keywords
compound
formula
alkyl
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3199816A
Other languages
English (en)
French (fr)
Inventor
James Richard FROST
Gregory William HASLETT
James Thomas Reuberson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Biopharma SRL
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB2017642.6A external-priority patent/GB202017642D0/en
Priority claimed from GBGB2108945.3A external-priority patent/GB202108945D0/en
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of CA3199816A1 publication Critical patent/CA3199816A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA3199816A 2020-11-09 2021-11-01 Dicyclopropylmethyl derivatives as il-17 modulators Pending CA3199816A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB2017642.6A GB202017642D0 (en) 2020-11-09 2020-11-09 Therapeputic agents
GB2017642.6 2020-11-09
GB2108945.3 2021-06-22
GBGB2108945.3A GB202108945D0 (en) 2021-06-22 2021-06-22 Therapeutic agents
PCT/EP2021/080251 WO2022096412A1 (en) 2020-11-09 2021-11-01 Dicyclopropylmethyl derivatives as il-17 modulators

Publications (1)

Publication Number Publication Date
CA3199816A1 true CA3199816A1 (en) 2022-05-12

Family

ID=78536191

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3199816A Pending CA3199816A1 (en) 2020-11-09 2021-11-01 Dicyclopropylmethyl derivatives as il-17 modulators

Country Status (6)

Country Link
US (1) US20230399328A1 (https=)
EP (1) EP4240742A1 (https=)
JP (1) JP2023551110A (https=)
CN (1) CN116406267A (https=)
CA (1) CA3199816A1 (https=)
WO (1) WO2022096412A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR126255A1 (es) 2021-07-01 2023-10-04 UCB Biopharma SRL Derivados de imidazotriazina como moduladores de il-17
WO2023025783A1 (en) 2021-08-23 2023-03-02 Leo Pharma A/S Small molecule modulators of il-17
WO2023111181A1 (en) 2021-12-16 2023-06-22 Leo Pharma A/S Small molecule modulators of il-17
WO2023166172A1 (en) 2022-03-04 2023-09-07 Leo Pharma A/S Small molecule modulators of il-17
GB202210731D0 (en) 2022-07-22 2022-09-07 UCB Biopharma SRL Therapeutic agents
TW202430165A (zh) 2022-12-02 2024-08-01 丹麥商理奧藥品公司 Il-17之小分子調節劑

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2242504B1 (en) 2008-01-09 2021-07-14 The Schepens Eye Research Institute, Inc. Therapeutic compositions for treatment of ocular inflammatory disorders
EP2809660B1 (en) 2012-02-02 2016-01-20 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating il-17
WO2014066726A2 (en) 2012-10-26 2014-05-01 Ensemble Therapeutics Corporation Compounds for modulating il-17
GB201709456D0 (en) 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents
US11472794B2 (en) * 2018-01-15 2022-10-18 UCB Biopharma SRL Fused imidazole derivatives as IL-17 modulators
CN110511213B (zh) 2018-05-22 2021-10-19 成都先导药物开发股份有限公司 一种免疫调节剂
EP3820567A1 (en) 2018-07-12 2021-05-19 UCB Biopharma SRL Spirocyclic indane analogues as il-17 modulators
GB201820165D0 (en) 2018-12-11 2019-01-23 Ucb Biopharma Sprl Therapeutic agents
GB201820166D0 (en) 2018-12-11 2019-01-23 Ucb Biopharma Sprl Therapeutic agents
SG11202106444WA (en) * 2018-12-19 2021-07-29 Leo Pharma As Amino-acid anilides as small molecule modulators of il-17
TWI752400B (zh) 2019-01-07 2022-01-11 美商美國禮來大藥廠 Il-17a抑制劑
US20220162191A1 (en) 2019-03-08 2022-05-26 Leo Pharma A/S Small molecule modulators of il-17
GB201909191D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
GB201909190D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
GB201909194D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents

Also Published As

Publication number Publication date
WO2022096412A1 (en) 2022-05-12
CN116406267A (zh) 2023-07-07
EP4240742A1 (en) 2023-09-13
JP2023551110A (ja) 2023-12-07
US20230399328A1 (en) 2023-12-14

Similar Documents

Publication Publication Date Title
JP7623301B2 (ja) Ｉｌ－１７調節剤としてのイミダゾピリジン誘導体
JP7482873B2 (ja) Ｉｌ－１７調節剤としてのベンズイミダゾロン誘導体及びその類似体
US11472794B2 (en) Fused imidazole derivatives as IL-17 modulators
JP7558210B2 (ja) Ｉｌ－１７調節剤としての縮合イミダゾール誘導体
US11458124B2 (en) Spirocyclic indane analogues as IL-17 modulators
EP3638227B1 (en) Spirocyclic indolines as il-17 modulators
WO2020120141A1 (en) Functionalised amine derivatives as il-17 modulators
CA3199816A1 (en) Dicyclopropylmethyl derivatives as il-17 modulators
WO2020260426A1 (en) Fused imidazole derivatives as il-17 modulators
CA3200594A1 (en) Imidazopyridazine derivatives as il-17 modulators
WO2021170631A1 (en) Difluorocyclohexyl derivatives as il-17 modulators
CA3179686A1 (en) Difluorocyclohexyl derivatives as il-17 modulators
WO2021170627A1 (en) Difluorocyclohexyl derivatives as il-17 modulators
WO2022096411A1 (en) Dicyclopropylmethyl derivatives as il-17 modulators

Legal Events

Date Code Title Description
W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20250818

U13 Renewal or maintenance fee not paid

Free format text: ST27 STATUS EVENT CODE: N-1-6-U10-U13-U300 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO MAINTENANCE FEE NOTICE

Effective date: 20251020

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20251217

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20251230