JP2023548295A5 - - Google Patents

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Publication number
JP2023548295A5
JP2023548295A5 JP2023525517A JP2023525517A JP2023548295A5 JP 2023548295 A5 JP2023548295 A5 JP 2023548295A5 JP 2023525517 A JP2023525517 A JP 2023525517A JP 2023525517 A JP2023525517 A JP 2023525517A JP 2023548295 A5 JP2023548295 A5 JP 2023548295A5
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JP
Japan
Prior art keywords
compound
salt
formula
absent
linking group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023525517A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023548295A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/058232 external-priority patent/WO2022098990A1/en
Publication of JP2023548295A publication Critical patent/JP2023548295A/ja
Publication of JP2023548295A5 publication Critical patent/JP2023548295A5/ja
Pending legal-status Critical Current

Links

JP2023525517A 2020-11-06 2021-11-05 修飾されたsiRNAを含む標的化コンジュゲート Pending JP2023548295A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063110837P 2020-11-06 2020-11-06
US63/110,837 2020-11-06
PCT/US2021/058232 WO2022098990A1 (en) 2020-11-06 2021-11-05 Targeted conjugates comprising modified sirna

Publications (2)

Publication Number Publication Date
JP2023548295A JP2023548295A (ja) 2023-11-16
JP2023548295A5 true JP2023548295A5 (enExample) 2024-11-13

Family

ID=81457390

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023525517A Pending JP2023548295A (ja) 2020-11-06 2021-11-05 修飾されたsiRNAを含む標的化コンジュゲート

Country Status (11)

Country Link
US (1) US20240052349A1 (enExample)
EP (1) EP4240369A4 (enExample)
JP (1) JP2023548295A (enExample)
KR (1) KR20230104652A (enExample)
CN (1) CN116472063A (enExample)
AU (1) AU2021376390A1 (enExample)
CA (1) CA3199757A1 (enExample)
IL (1) IL302530A (enExample)
MX (1) MX2023005138A (enExample)
TW (1) TW202233243A (enExample)
WO (1) WO2022098990A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI859114B (zh) * 2016-04-11 2024-10-21 加拿大商艾爾布圖斯生技公司 靶向組合物
TWI866590B (zh) * 2022-11-08 2024-12-11 大陸商南京明德新藥研發有限公司 含七元雜環的四價綴合基團及其應用
WO2026061476A1 (zh) * 2024-09-19 2026-03-26 长春金赛药业有限责任公司 一种多簇连接子、其制备方法及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050222064A1 (en) * 2002-02-20 2005-10-06 Sirna Therapeutics, Inc. Polycationic compositions for cellular delivery of polynucleotides
US20130190383A1 (en) * 2010-04-26 2013-07-25 Marina Biotech, Inc. Nucleic acid compounds with conformationally restricted monomers and uses thereof
JP6924744B2 (ja) * 2015-07-17 2021-08-25 アークトゥラス・セラピューティクス・インコーポレイテッドArcturus Therapeutics,Inc. B型肝炎ウイルスに対する組成物および薬剤ならびにその使用
TWI859114B (zh) * 2016-04-11 2024-10-21 加拿大商艾爾布圖斯生技公司 靶向組合物
CA3059426A1 (en) * 2017-04-11 2018-10-18 Arbutus Biopharma Corporation Targeted compositions
US11324820B2 (en) * 2017-04-18 2022-05-10 Alnylam Pharmaceuticals, Inc. Methods for the treatment of subjects having a hepatitis b virus (HBV) infection
CN111212909A (zh) * 2017-10-17 2020-05-29 箭头药业股份有限公司 用于抑制去唾液酸糖蛋白受体1的表达的RNAi试剂和组合物
MA55375A (fr) * 2019-03-20 2022-01-26 Arbutus Biopharma Corp Méthodes thérapeutiques de traitement de l'hépatite b

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