JP2023536320A5 - - Google Patents
Info
- Publication number
- JP2023536320A5 JP2023536320A5 JP2023507494A JP2023507494A JP2023536320A5 JP 2023536320 A5 JP2023536320 A5 JP 2023536320A5 JP 2023507494 A JP2023507494 A JP 2023507494A JP 2023507494 A JP2023507494 A JP 2023507494A JP 2023536320 A5 JP2023536320 A5 JP 2023536320A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- modified
- nucleotide
- sirna
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010772542.6 | 2020-08-04 | ||
| CN202010772542 | 2020-08-04 | ||
| CN202110244977.8 | 2021-03-05 | ||
| CN202110244977 | 2021-03-05 | ||
| CN202110361502 | 2021-04-02 | ||
| CN202110361502.7 | 2021-04-02 | ||
| PCT/CN2021/110509 WO2022028462A1 (zh) | 2020-08-04 | 2021-08-04 | 脱靶活性降低的修饰sirna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2026064108A Division JP2026129742A (ja) | 2020-08-04 | 2026-04-09 | オフターゲット活性が低減された修飾ｓｉＲＮＡ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023536320A JP2023536320A (ja) | 2023-08-24 |
| JP2023536320A5 true JP2023536320A5 (enExample) | 2024-07-30 |
| JP7849353B2 JP7849353B2 (ja) | 2026-04-21 |
Family
ID=80120017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023507494A Active JP7849353B2 (ja) | 2020-08-04 | 2021-08-04 | オフターゲット活性が低減された修飾ｓｉＲＮＡ |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230287418A1 (enExample) |
| EP (1) | EP4194553A4 (enExample) |
| JP (1) | JP7849353B2 (enExample) |
| KR (1) | KR20230043195A (enExample) |
| CN (1) | CN115955973A (enExample) |
| BR (1) | BR112023002080A2 (enExample) |
| CA (1) | CA3190097A1 (enExample) |
| TW (1) | TW202214858A (enExample) |
| WO (1) | WO2022028462A1 (enExample) |
| ZA (1) | ZA202303275B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
| WO2022206946A1 (zh) * | 2021-04-02 | 2022-10-06 | 上海拓界生物医药科技有限公司 | 乙型肝炎病毒siRNA和siRNA缀合物 |
| EP4328310A4 (en) * | 2021-04-22 | 2025-10-15 | Tuojie Biotech Shanghai Co Ltd | SIRNA TARGETING 17β-HYDROXYSTEROID DEHYDROGENASE TYPE 13 AND SIRNA CONJUGATE |
| WO2023109932A1 (zh) * | 2021-12-16 | 2023-06-22 | 上海拓界生物医药科技有限公司 | 一种dsRNA、其制备方法及应用 |
| TW202340469A (zh) | 2022-01-20 | 2023-10-16 | 大陸商上海拓界生物醫藥科技有限公司 | 一種ｄｓｒｎａ、其應用及製備方法 |
| EP4635967A1 (en) * | 2022-12-13 | 2025-10-22 | Tuojie Biotech (Shanghai) Co., Ltd. | Oligonucleotide comprising lipophilic monomer and use thereof in non-liver delivery |
| CN120615096A (zh) * | 2023-02-21 | 2025-09-09 | 成都先导药物开发股份有限公司 | 核苷酸类似物及其制备方法和用途 |
| US20260234620A1 (en) | 2023-03-02 | 2026-08-13 | Tuojie Biotech (Shanghai) Co., Ltd. | siRNA Targeting Inhibin BetaE, siRNA Conjugate, And Medical Use Thereof |
| AU2024258620A1 (en) * | 2023-04-21 | 2025-11-06 | Suzhou Siran Biotechnology Co., Ltd. | Oligomeric nucleic acid, and preparation method therefore and use thereof |
| TW202442243A (zh) | 2023-04-27 | 2024-11-01 | 大陸商上海森輝醫藥有限公司 | 用於製備寡核苷酸類似物或其鹽的中間體及其製備方法 |
| KR20260020955A (ko) | 2023-05-31 | 2026-02-12 | 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 | LPA를 표적화하는 dsRNA 및 이의 응용 |
| MX2025014897A (es) | 2023-06-13 | 2026-02-03 | Tuojie Biotech Shanghai Co Ltd | Arnip dirigido a mmp7, conjugado de arnip y su uso medico |
| WO2025007907A1 (zh) * | 2023-07-04 | 2025-01-09 | 大睿生物 | 包含肽的寡核苷酸递送配体 |
| KR20260046111A (ko) | 2023-08-01 | 2026-04-06 | 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 | MAPT를 표적으로 하는 dsRNA 및 이의 의약적 용도 |
| CN121586578A (zh) | 2023-08-24 | 2026-02-27 | 上海拓界生物医药科技有限公司 | 靶向RAGE的RNAi剂及其医药用途 |
| KR20260089666A (ko) * | 2023-09-14 | 2026-06-15 | 아이오니스 파마수티컬즈, 인코포레이티드 | Apociii 발현을 감소시키기 위한 화합물 및 방법 |
| WO2025067317A1 (zh) * | 2023-09-26 | 2025-04-03 | 上海拓界生物医药科技有限公司 | 一种脂质修饰的核酸化合物、其制备方法及用途 |
| CN120209036A (zh) * | 2023-12-26 | 2025-06-27 | 广东东阳光药业股份有限公司 | 一种新型的化合物及其用途 |
| WO2026002138A1 (zh) * | 2024-06-27 | 2026-01-02 | 成都新泽利医药科技有限公司 | 特定修饰的双链寡核苷酸及其组合物 |
| CN121175422A (zh) * | 2024-10-08 | 2025-12-19 | 北京安龙生物医药有限公司 | 修饰的双链寡核苷酸及其缀合物和组合物 |
| CN119410644A (zh) * | 2025-01-08 | 2025-02-11 | 北京安龙生物医药有限公司 | 修饰的双链寡核苷酸及其缀合物和组合物 |
| CN119528986B (zh) * | 2025-01-23 | 2025-09-16 | 北京悦康科创医药科技股份有限公司 | 一种核苷类似物及其在降低寡核苷酸药物脱靶活性中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1798225A1 (en) * | 2004-09-16 | 2007-06-20 | Gifu University | Nucleoside analogues or salts thereof |
| EP3643782A1 (en) * | 2008-02-11 | 2020-04-29 | Phio Pharmaceuticals Corp. | Modified rnai polynucleotides and uses thereof |
| CA2744093A1 (en) * | 2008-12-03 | 2010-06-10 | Marina Biotech, Inc. | Una oligomer structures for therapeutic agents |
| EP4253395A3 (en) | 2012-08-06 | 2023-11-29 | Alnylam Pharmaceuticals, Inc. | Processes for the preparation of carbohydrate conjugated rna agents |
| WO2016081444A1 (en) * | 2014-11-17 | 2016-05-26 | Alnylam Pharmaceuticals, Inc. | Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof |
| AU2016371624B2 (en) * | 2015-12-13 | 2020-08-27 | Nitto Denko Corporation | siRNA structures for high activity and reduced off target |
| CN107400669A (zh) * | 2016-08-18 | 2017-11-28 | 广州市锐博生物科技有限公司 | 用于抑制HIF1A靶基因mRNA表达的寡核酸分子及其成套组合物 |
| WO2018098328A1 (en) | 2016-11-23 | 2018-05-31 | Alnylam Pharmaceuticals, Inc. | Modified rna agents with reduced off-target effect |
| EP3802827A4 (en) | 2018-05-16 | 2022-08-03 | Alnylam Pharmaceuticals, Inc. | MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT |
| CN111378655B (zh) * | 2018-12-28 | 2024-03-19 | 苏州瑞博生物技术股份有限公司 | 抑制CTGF基因表达的siRNA、含有该siRNA的药物组合物及其用途 |
| CN111378657B (zh) * | 2018-12-28 | 2024-03-15 | 苏州瑞博生物技术股份有限公司 | 抑制COL1A1基因表达的siRNA、含有该siRNA的药物组合物及其用途 |
| CN111378656B (zh) * | 2018-12-28 | 2022-07-26 | 苏州瑞博生物技术股份有限公司 | 一种抑制埃博拉病毒的核酸、含有该核酸的药物组合物及其用途 |
| EP4328310A4 (en) | 2021-04-22 | 2025-10-15 | Tuojie Biotech Shanghai Co Ltd | SIRNA TARGETING 17β-HYDROXYSTEROID DEHYDROGENASE TYPE 13 AND SIRNA CONJUGATE |
-
2021
- 2021-08-04 KR KR1020237006847A patent/KR20230043195A/ko active Pending
- 2021-08-04 CN CN202180048996.1A patent/CN115955973A/zh active Pending
- 2021-08-04 BR BR112023002080A patent/BR112023002080A2/pt unknown
- 2021-08-04 TW TW110128792A patent/TW202214858A/zh unknown
- 2021-08-04 WO PCT/CN2021/110509 patent/WO2022028462A1/zh not_active Ceased
- 2021-08-04 US US18/019,763 patent/US20230287418A1/en active Pending
- 2021-08-04 EP EP21852482.5A patent/EP4194553A4/en active Pending
- 2021-08-04 CA CA3190097A patent/CA3190097A1/en active Pending
- 2021-08-04 JP JP2023507494A patent/JP7849353B2/ja active Active
-
2023
- 2023-03-02 ZA ZA2023/03275A patent/ZA202303275B/en unknown