JP2023536320A5 - - Google Patents
Info
- Publication number
- JP2023536320A5 JP2023536320A5 JP2023507494A JP2023507494A JP2023536320A5 JP 2023536320 A5 JP2023536320 A5 JP 2023536320A5 JP 2023507494 A JP2023507494 A JP 2023507494A JP 2023507494 A JP2023507494 A JP 2023507494A JP 2023536320 A5 JP2023536320 A5 JP 2023536320A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- modified
- nucleotide
- sirna
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010772542 | 2020-08-04 | ||
| CN202010772542.6 | 2020-08-04 | ||
| CN202110244977 | 2021-03-05 | ||
| CN202110244977.8 | 2021-03-05 | ||
| CN202110361502.7 | 2021-04-02 | ||
| CN202110361502 | 2021-04-02 | ||
| PCT/CN2021/110509 WO2022028462A1 (zh) | 2020-08-04 | 2021-08-04 | 脱靶活性降低的修饰sirna |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023536320A JP2023536320A (ja) | 2023-08-24 |
| JP2023536320A5 true JP2023536320A5 (enExample) | 2024-07-30 |
| JP7849353B2 JP7849353B2 (ja) | 2026-04-21 |
Family
ID=80120017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023507494A Active JP7849353B2 (ja) | 2020-08-04 | 2021-08-04 | オフターゲット活性が低減された修飾ｓｉＲＮＡ |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230287418A1 (enExample) |
| EP (1) | EP4194553A4 (enExample) |
| JP (1) | JP7849353B2 (enExample) |
| KR (1) | KR20230043195A (enExample) |
| CN (1) | CN115955973A (enExample) |
| BR (1) | BR112023002080A2 (enExample) |
| CA (1) | CA3190097A1 (enExample) |
| TW (1) | TW202214858A (enExample) |
| WO (1) | WO2022028462A1 (enExample) |
| ZA (1) | ZA202303275B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019006455A1 (en) | 2017-06-30 | 2019-01-03 | Solstice Biologics, Ltd. | AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF |
| WO2022206946A1 (zh) * | 2021-04-02 | 2022-10-06 | 上海拓界生物医药科技有限公司 | 乙型肝炎病毒siRNA和siRNA缀合物 |
| EP4328310A4 (en) * | 2021-04-22 | 2025-10-15 | Tuojie Biotech Shanghai Co Ltd | SIRNA TARGETING 17β-HYDROXYSTEROID DEHYDROGENASE TYPE 13 AND SIRNA CONJUGATE |
| CN118339294A (zh) * | 2021-12-16 | 2024-07-12 | 上海拓界生物医药科技有限公司 | 一种dsRNA、其制备方法及应用 |
| EP4467645A4 (en) * | 2022-01-20 | 2026-01-21 | Tuojie Biotech Shanghai Co Ltd | DOUBLE-STRANDED RNA, ITS USES AND PREPARATION PROCESS |
| EP4635967A1 (en) * | 2022-12-13 | 2025-10-22 | Tuojie Biotech (Shanghai) Co., Ltd. | Oligonucleotide comprising lipophilic monomer and use thereof in non-liver delivery |
| KR20250134660A (ko) * | 2023-02-21 | 2025-09-11 | 히트젠 주식회사 | 뉴클레오티드 유사체 및 그 제조 방법과 용도 |
| JP2026507146A (ja) | 2023-03-02 | 2026-02-27 | 上海拓界生物医薬科技有限公司 | インヒビンβＥを標的とするｓｉＲＮＡ、ｓｉＲＮＡ複合体及びその医薬的使用 |
| AU2024258620A1 (en) * | 2023-04-21 | 2025-11-06 | Suzhou Siran Biotechnology Co., Ltd. | Oligomeric nucleic acid, and preparation method therefore and use thereof |
| CN120957994A (zh) | 2023-04-27 | 2025-11-14 | 上海森辉医药有限公司 | 用于制备寡核苷酸类似物或其盐的中间体及其制备方法 |
| AU2024280186A1 (en) | 2023-05-31 | 2025-12-04 | Tuojie Biotech (Shanghai) Co., Ltd. | Dsrna targeting lpa and use thereof |
| KR20260026026A (ko) | 2023-06-13 | 2026-02-25 | 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 | MMP7을 표적으로 하는 siRNA, siRNA 접합체 및 이의 의학적 용도 |
| CN121569035A (zh) * | 2023-07-04 | 2026-02-24 | 大睿生物医药科技(上海)有限公司 | 包含肽的寡核苷酸递送配体 |
| KR20260046111A (ko) | 2023-08-01 | 2026-04-06 | 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 | MAPT를 표적으로 하는 dsRNA 및 이의 의약적 용도 |
| AU2024329194A1 (en) | 2023-08-24 | 2026-02-19 | Tuojie Biotech (Shanghai) Co., Ltd. | Rage-targeted rnai agent and pharmaceutical use thereof |
| AU2024342933A1 (en) * | 2023-09-14 | 2026-03-26 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing apociii expression |
| WO2025067317A1 (zh) * | 2023-09-26 | 2025-04-03 | 上海拓界生物医药科技有限公司 | 一种脂质修饰的核酸化合物、其制备方法及用途 |
| WO2025140299A1 (zh) * | 2023-12-26 | 2025-07-03 | 广东东阳光药业股份有限公司 | 一种新型的化合物及其用途 |
| WO2026002138A1 (zh) * | 2024-06-27 | 2026-01-02 | 成都新泽利医药科技有限公司 | 特定修饰的双链寡核苷酸及其组合物 |
| CN119410644A (zh) * | 2025-01-08 | 2025-02-11 | 北京安龙生物医药有限公司 | 修饰的双链寡核苷酸及其缀合物和组合物 |
| CN119528986B (zh) * | 2025-01-23 | 2025-09-16 | 北京悦康科创医药科技股份有限公司 | 一种核苷类似物及其在降低寡核苷酸药物脱靶活性中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4887500B2 (ja) * | 2004-09-16 | 2012-02-29 | 国立大学法人岐阜大学 | ヌクレオシド類似体またはその塩 |
| EP2247729B1 (en) * | 2008-02-11 | 2019-05-01 | Phio Pharmaceuticals Corp. | Modified rnai polynucleotides and uses thereof |
| JP5816556B2 (ja) * | 2008-12-03 | 2015-11-18 | アークトゥラス・セラピューティクス・インコーポレイテッドＡｒｃｔｕｒｕｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 治療剤のためのｕｎａオリゴマー構造 |
| AU2013299717B2 (en) | 2012-08-06 | 2018-06-28 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugated RNA agents and process for their preparation |
| CA2968114A1 (en) * | 2014-11-17 | 2016-05-26 | Alnylam Pharmaceuticals, Inc. | Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof |
| US10358647B2 (en) * | 2015-12-13 | 2019-07-23 | Nitto Denko Corporation | siRNA structures for high activity and reduced off target |
| CN107365771B (zh) * | 2016-08-18 | 2020-11-10 | 广州市锐博生物科技有限公司 | 用于抑制CTNNB1靶基因mRNA表达的寡核酸分子及其成套组合物 |
| KR102645243B1 (ko) * | 2016-11-23 | 2024-03-11 | 알닐람 파마슈티칼스 인코포레이티드 | 표적외 효과가 감소된 변형 rna 작용제 |
| US12247203B2 (en) * | 2018-05-16 | 2025-03-11 | Alnylam Pharmaceuticals, Inc. | Modified RNA agents with reduced off-target effect |
| CN111378656B (zh) * | 2018-12-28 | 2022-07-26 | 苏州瑞博生物技术股份有限公司 | 一种抑制埃博拉病毒的核酸、含有该核酸的药物组合物及其用途 |
| CN111378655B (zh) * | 2018-12-28 | 2024-03-19 | 苏州瑞博生物技术股份有限公司 | 抑制CTGF基因表达的siRNA、含有该siRNA的药物组合物及其用途 |
| CN111378657B (zh) * | 2018-12-28 | 2024-03-15 | 苏州瑞博生物技术股份有限公司 | 抑制COL1A1基因表达的siRNA、含有该siRNA的药物组合物及其用途 |
| EP4328310A4 (en) * | 2021-04-22 | 2025-10-15 | Tuojie Biotech Shanghai Co Ltd | SIRNA TARGETING 17β-HYDROXYSTEROID DEHYDROGENASE TYPE 13 AND SIRNA CONJUGATE |
-
2021
- 2021-08-04 EP EP21852482.5A patent/EP4194553A4/en active Pending
- 2021-08-04 WO PCT/CN2021/110509 patent/WO2022028462A1/zh not_active Ceased
- 2021-08-04 US US18/019,763 patent/US20230287418A1/en active Pending
- 2021-08-04 CA CA3190097A patent/CA3190097A1/en active Pending
- 2021-08-04 TW TW110128792A patent/TW202214858A/zh unknown
- 2021-08-04 CN CN202180048996.1A patent/CN115955973A/zh active Pending
- 2021-08-04 KR KR1020237006847A patent/KR20230043195A/ko active Pending
- 2021-08-04 BR BR112023002080A patent/BR112023002080A2/pt unknown
- 2021-08-04 JP JP2023507494A patent/JP7849353B2/ja active Active
-
2023
- 2023-03-02 ZA ZA2023/03275A patent/ZA202303275B/en unknown