TW202214858A - 脫靶活性降低的修飾siRNA - Google Patents

脫靶活性降低的修飾siRNA Download PDF

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TW202214858A
TW202214858A TW110128792A TW110128792A TW202214858A TW 202214858 A TW202214858 A TW 202214858A TW 110128792 A TW110128792 A TW 110128792A TW 110128792 A TW110128792 A TW 110128792A TW 202214858 A TW202214858 A TW 202214858A
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methoxy
sirna
nucleotide
alkynyl
alkenyl
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TW110128792A
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黃金宇
羅敏
尹科
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大陸商上海拓界生物醫藥科技有限公司
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TW110128792A 2020-08-04 2021-08-04 脫靶活性降低的修飾siRNA TW202214858A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN202010772542.6 2020-08-04
CN202010772542 2020-08-04
CN202110244977.8 2021-03-05
CN202110244977 2021-03-05
CN202110361502.7 2021-04-02
CN202110361502 2021-04-02

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EP (1) EP4194553A4 (enExample)
JP (1) JP7849353B2 (enExample)
KR (1) KR20230043195A (enExample)
CN (1) CN115955973A (enExample)
BR (1) BR112023002080A2 (enExample)
CA (1) CA3190097A1 (enExample)
TW (1) TW202214858A (enExample)
WO (1) WO2022028462A1 (enExample)
ZA (1) ZA202303275B (enExample)

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CA3216332A1 (en) * 2021-04-22 2022-10-27 Tuojie Biotech (Shanghai) Co., Ltd. Sirna targeting 17b-hydroxysteroid dehydrogenase type 13 and sirna conjugate
CN118339294A (zh) * 2021-12-16 2024-07-12 上海拓界生物医药科技有限公司 一种dsRNA、其制备方法及应用
TW202340469A (zh) * 2022-01-20 2023-10-16 大陸商上海拓界生物醫藥科技有限公司 一種ｄｓｒｎａ、其應用及製備方法
JP2025541262A (ja) * 2022-12-13 2025-12-18 上海拓界生物医薬科技有限公司 親油性モノマーを含むオリゴヌクレオチド及びその非肝臓送達における使用
WO2024175013A1 (zh) * 2023-02-21 2024-08-29 成都先导药物开发股份有限公司 核苷酸类似物及其制备方法和用途
WO2024179573A1 (zh) 2023-03-02 2024-09-06 上海拓界生物医药科技有限公司 靶向抑制素βE的siRNA、siRNA缀合物及其医药用途
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CN121079106A (zh) 2023-05-31 2025-12-05 上海拓界生物医药科技有限公司 一种靶向LPA的dsRNA及其应用
TW202503060A (zh) 2023-06-13 2025-01-16 大陸商上海拓界生物醫藥科技有限公司 靶向ＭＭＰ７的ｓｉＲＮＡ、ｓｉＲＮＡ綴合物及其醫藥用途
WO2025007907A1 (zh) * 2023-07-04 2025-01-09 大睿生物 包含肽的寡核苷酸递送配体
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TW202509217A (zh) 2023-08-24 2025-03-01 大陸商上海拓界生物醫藥科技有限公司 靶向ＲＡＧＥ的ＲＮＡｉ劑及其醫藥用途
TW202526017A (zh) * 2023-09-14 2025-07-01 美商Ionis製藥公司 用於減少ａｐｏｃｉｉｉ表現的化合物及方法
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CN120209036A (zh) * 2023-12-26 2025-06-27 广东东阳光药业股份有限公司 一种新型的化合物及其用途
WO2026002138A1 (zh) * 2024-06-27 2026-01-02 成都新泽利医药科技有限公司 特定修饰的双链寡核苷酸及其组合物
CN119410644A (zh) * 2025-01-08 2025-02-11 北京安龙生物医药有限公司 修饰的双链寡核苷酸及其缀合物和组合物
CN119528986B (zh) * 2025-01-23 2025-09-16 北京悦康科创医药科技股份有限公司 一种核苷类似物及其在降低寡核苷酸药物脱靶活性中的应用

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CA3190097A1 (en) 2022-02-10
JP7849353B2 (ja) 2026-04-21
KR20230043195A (ko) 2023-03-30
BR112023002080A2 (pt) 2023-04-25
WO2022028462A1 (zh) 2022-02-10
CN115955973A (zh) 2023-04-11
EP4194553A1 (en) 2023-06-14
JP2023536320A (ja) 2023-08-24
US20230287418A1 (en) 2023-09-14
ZA202303275B (en) 2025-12-17

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