JP2023546796A - イソアスパラギン酸を検出する方法 - Google Patents

イソアスパラギン酸を検出する方法 Download PDF

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JP2023546796A
JP2023546796A JP2023519654A JP2023519654A JP2023546796A JP 2023546796 A JP2023546796 A JP 2023546796A JP 2023519654 A JP2023519654 A JP 2023519654A JP 2023519654 A JP2023519654 A JP 2023519654A JP 2023546796 A JP2023546796 A JP 2023546796A
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isoasp
protein
peptide
mass spectrometry
tof
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JP2023546796A5 (https=
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ホイ，ジョン・オン－ティン
カンプサーノ，イアン・デイビッド・グラント
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アムジエン・インコーポレーテツド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
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  • Hematology (AREA)
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  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
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  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2023519654A 2020-10-01 2021-09-30 イソアスパラギン酸を検出する方法 Pending JP2023546796A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063086557P 2020-10-01 2020-10-01
US63/086,557 2020-10-01
US202163218186P 2021-07-02 2021-07-02
US63/218,186 2021-07-02
PCT/US2021/052783 WO2022072583A1 (en) 2020-10-01 2021-09-30 Methods of detecting isoaspartic acid

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JP2023546796A true JP2023546796A (ja) 2023-11-08
JP2023546796A5 JP2023546796A5 (https=) 2024-10-07

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US (1) US20230366889A1 (https=)
EP (1) EP4222500B1 (https=)
JP (1) JP2023546796A (https=)
CN (1) CN116348770A (https=)
AU (1) AU2021351498A1 (https=)
CA (1) CA3196920A1 (https=)
ES (1) ES3059573T3 (https=)
MX (1) MX2023003862A (https=)
TW (1) TWI907533B (https=)
WO (1) WO2022072583A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114144668B (zh) * 2019-07-17 2025-02-11 株式会社岛津制作所 异天冬氨酸的分析方法和质谱分析装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018044826A (ja) * 2016-09-13 2018-03-22 株式会社島津製作所 ペプチド解析方法、ペプチド解析装置、及びペプチド解析用プログラム
US20190073452A1 (en) * 2015-09-25 2019-03-07 Bioanalytix, Inc. Method for determining the in vivo comparability of a biologic drug and a reference drug
CN110779979A (zh) * 2019-10-09 2020-02-11 南昌大学 一种基于寡糖异构体组成差异鉴别蜂蜜糖浆掺假的方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190073452A1 (en) * 2015-09-25 2019-03-07 Bioanalytix, Inc. Method for determining the in vivo comparability of a biologic drug and a reference drug
JP2018044826A (ja) * 2016-09-13 2018-03-22 株式会社島津製作所 ペプチド解析方法、ペプチド解析装置、及びペプチド解析用プログラム
CN110779979A (zh) * 2019-10-09 2020-02-11 南昌大学 一种基于寡糖异构体组成差异鉴别蜂蜜糖浆掺假的方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JOHN O.HUI: "A Robust MALDI‐PSD Method for Site Specific Identification of Isomerized Aspartate Residue in Thera", PROC. OF THE 2ND ADVANCING MASS SPECTROMETRY FOR BIOPHYSICS AND STRUCTURAL BIOLOGY MEETING, JPN7025003597, 2019, pages 32, ISSN: 0005817923 *
NICK DEGRAAN-WEBER: "Distinguishing Aspartic and lsoaspartic Acids in Peptides by Several Mass Spectrometric Fragmentatio", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 27, no. 12, JPN7025003596, 2016, pages 2041 - 2053, ISSN: 0005817922 *
STANISLAV I. PEKOV: "Evaluation of MALDI-TOF/TOF Mass Spectrometry Approach for Quantitative Determination of Aspartate R", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 30, JPN7025003598, 2019, pages 1325 - 1329, ISSN: 0005666031 *
VICKI H. WYSOCKI: "Mobile and localized protons: a framework for understanding peptide dissociation", J.MASS SPECTROM., vol. 35, JPN7025003599, 2000, pages 1399 - 1406, ISSN: 0005666032 *

Also Published As

Publication number Publication date
EP4222500B1 (en) 2025-11-12
WO2022072583A1 (en) 2022-04-07
TWI907533B (zh) 2025-12-11
MX2023003862A (es) 2023-04-14
AU2021351498A1 (en) 2023-05-04
EP4222500C0 (en) 2025-11-12
CA3196920A1 (en) 2022-04-07
CN116348770A (zh) 2023-06-27
EP4222500A1 (en) 2023-08-09
TW202223377A (zh) 2022-06-16
ES3059573T3 (en) 2026-03-23
AU2021351498A9 (en) 2025-03-27
US20230366889A1 (en) 2023-11-16

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