TWI907533B - 異天冬胺酸之檢測方法 - Google Patents
異天冬胺酸之檢測方法Info
- Publication number
- TWI907533B TWI907533B TW110136572A TW110136572A TWI907533B TW I907533 B TWI907533 B TW I907533B TW 110136572 A TW110136572 A TW 110136572A TW 110136572 A TW110136572 A TW 110136572A TW I907533 B TWI907533 B TW I907533B
- Authority
- TW
- Taiwan
- Prior art keywords
- protein
- cdata
- peptide
- isoasp
- tof
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063086557P | 2020-10-01 | 2020-10-01 | |
| US63/086,557 | 2020-10-01 | ||
| US202163218186P | 2021-07-02 | 2021-07-02 | |
| US63/218,186 | 2021-07-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202223377A TW202223377A (zh) | 2022-06-16 |
| TWI907533B true TWI907533B (zh) | 2025-12-11 |
Family
ID=78621972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW110136572A TWI907533B (zh) | 2020-10-01 | 2021-09-30 | 異天冬胺酸之檢測方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230366889A1 (https=) |
| EP (1) | EP4222500B1 (https=) |
| JP (1) | JP2023546796A (https=) |
| CN (1) | CN116348770A (https=) |
| AU (1) | AU2021351498A1 (https=) |
| CA (1) | CA3196920A1 (https=) |
| ES (1) | ES3059573T3 (https=) |
| MX (1) | MX2023003862A (https=) |
| TW (1) | TWI907533B (https=) |
| WO (1) | WO2022072583A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114144668B (zh) * | 2019-07-17 | 2025-02-11 | 株式会社岛津制作所 | 异天冬氨酸的分析方法和质谱分析装置 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190073452A1 (en) * | 2015-09-25 | 2019-03-07 | Bioanalytix, Inc. | Method for determining the in vivo comparability of a biologic drug and a reference drug |
| JP6665740B2 (ja) * | 2016-09-13 | 2020-03-13 | 株式会社島津製作所 | ペプチド解析方法、ペプチド解析装置、及びペプチド解析用プログラム |
| CN110779979A (zh) * | 2019-10-09 | 2020-02-11 | 南昌大学 | 一种基于寡糖异构体组成差异鉴别蜂蜜糖浆掺假的方法 |
-
2021
- 2021-09-30 TW TW110136572A patent/TWI907533B/zh active
- 2021-09-30 WO PCT/US2021/052783 patent/WO2022072583A1/en not_active Ceased
- 2021-09-30 ES ES21807318T patent/ES3059573T3/es active Active
- 2021-09-30 EP EP21807318.7A patent/EP4222500B1/en active Active
- 2021-09-30 MX MX2023003862A patent/MX2023003862A/es unknown
- 2021-09-30 AU AU2021351498A patent/AU2021351498A1/en active Pending
- 2021-09-30 US US18/245,004 patent/US20230366889A1/en active Pending
- 2021-09-30 CN CN202180067521.7A patent/CN116348770A/zh active Pending
- 2021-09-30 JP JP2023519654A patent/JP2023546796A/ja active Pending
- 2021-09-30 CA CA3196920A patent/CA3196920A1/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 期刊 DeGraan-Weber, Nick et al. Distinguishing Aspartic and Isoaspartic Acids in Peptides by Several Mass Spectrometric Fragmentation Methods. Journal of the American Society for Mass Spectrometry vol. 27,12 2016/09/09 2041-2053 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4222500B1 (en) | 2025-11-12 |
| WO2022072583A1 (en) | 2022-04-07 |
| MX2023003862A (es) | 2023-04-14 |
| AU2021351498A1 (en) | 2023-05-04 |
| EP4222500C0 (en) | 2025-11-12 |
| CA3196920A1 (en) | 2022-04-07 |
| CN116348770A (zh) | 2023-06-27 |
| EP4222500A1 (en) | 2023-08-09 |
| TW202223377A (zh) | 2022-06-16 |
| ES3059573T3 (en) | 2026-03-23 |
| JP2023546796A (ja) | 2023-11-08 |
| AU2021351498A9 (en) | 2025-03-27 |
| US20230366889A1 (en) | 2023-11-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Johnson et al. | Cation exchange–HPLC and mass spectrometry reveal C-terminal amidation of an IgG1 heavy chain | |
| Jansson | Strategies for analysis of isomeric peptides | |
| US10281473B2 (en) | Compositions and methods for analysis of protein sequences and post-translational modifications | |
| JP5903051B2 (ja) | ポリペプチドの配列バリアントの決定方法 | |
| US9181326B2 (en) | Analysis of ubiquitinated polypeptides | |
| Yu et al. | Accurate determination of succinimide degradation products using high fidelity trypsin digestion peptide map analysis | |
| Pham et al. | De novo proteomic sequencing of a monoclonal antibody raised against OX40 ligand | |
| Liu et al. | Quantitation of asparagine deamidation by isotope labeling and liquid chromatography coupled with mass spectrometry analysis | |
| TWI907533B (zh) | 異天冬胺酸之檢測方法 | |
| KR20090058403A (ko) | 단백질 타이로신 탈인산화 효소의 양적 감시에 의한 질환의 진단 방법 | |
| WO2021180063A1 (en) | Methods for detecting and quantifying biological modifications in antibodies | |
| Hui et al. | Unequivocal Identification of Aspartic Acid and iso Aspartic Acid by MALDI-TOF/TOF: From Peptide Standards to a Therapeutic Antibody | |
| US11352418B2 (en) | Analysis of ubiquitinated polypeptides | |
| Wu et al. | Localizing Isomerized Residue Sites in Peptides with Tandem Mass Spectrometry | |
| Klapoetke et al. | Disulfide bond characterization of human factor Xa by mass spectrometry through protein-level partial reduction | |
| US20220326252A1 (en) | Electron transfer dissociation and mass spectrometry for improved protein sequencing of monoclonal antibodies | |
| CN114829927B (zh) | 用于质谱蛋白质分析的材料和方法 | |
| Sousa et al. | Primary sequence determination of a monoclonal antibody against α-synuclein using a novel mass spectrometry-based approach | |
| JP2023530712A (ja) | 未処理ｃ末端リジンを正確に測定するための重ペプチドアプローチ | |
| KR101758862B1 (ko) | 질량분석 기반 정량분석법을 이용한 아밀로이드 단백질의 아형 진단 방법 | |
| US20240109958A1 (en) | Anti-ubiquitination antibodies and methods of use | |
| Gan | Salt Free HILIC-MS/MS as a Comprehensive and Complementary Site-Specific Glycosylation Tool in Therapeutic Proteins, Expanding Structural Resolution of Glycan Isomers | |
| JP2024540180A (ja) | Ｍｓベースのプロテオミクスのためのジスルフィドスクランブルを防止するための方法 | |
| JP2024535259A (ja) | 非還元ペプチドマッピングにおける試料調製により誘発されるジスルフィドスクランブリングを防止するための方法 | |
| Liu | Development of methods for the analysis of protein post-translational modifications: isoaspartic acid and protein crosslinking. |