JP2023546055A5 - - Google Patents
Info
- Publication number
- JP2023546055A5 JP2023546055A5 JP2023522411A JP2023522411A JP2023546055A5 JP 2023546055 A5 JP2023546055 A5 JP 2023546055A5 JP 2023522411 A JP2023522411 A JP 2023522411A JP 2023522411 A JP2023522411 A JP 2023522411A JP 2023546055 A5 JP2023546055 A5 JP 2023546055A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- ring
- depending
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2020/120605 | 2020-10-13 | ||
| CN2020120605 | 2020-10-13 | ||
| CN2021116470 | 2021-09-03 | ||
| CNPCT/CN2021/116470 | 2021-09-03 | ||
| PCT/CN2021/123619 WO2022078407A1 (en) | 2020-10-13 | 2021-10-13 | Heterocyclic glp-1 agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023546055A JP2023546055A (ja) | 2023-11-01 |
| JP2023546055A5 true JP2023546055A5 (https=) | 2025-02-07 |
Family
ID=81208935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023522411A Pending JP2023546055A (ja) | 2020-10-13 | 2021-10-13 | ヘテロ環ｇｌｐ－１アゴニスト |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230391760A1 (https=) |
| EP (1) | EP4229050A4 (https=) |
| JP (1) | JP2023546055A (https=) |
| CN (1) | CN116547279A (https=) |
| WO (1) | WO2022078407A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202206429A (zh) | 2020-04-29 | 2022-02-16 | 美商迦舒布魯姆生物有限公司 | 雜環ｇｌｐ—１促效劑 |
| JP2023537501A (ja) | 2020-08-06 | 2023-09-01 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環ｇｌｐ－１アゴニスト |
| EP4204415A4 (en) | 2020-08-28 | 2025-03-26 | Gasherbrum Bio, Inc. | HETEROCYCLIC GLP-1 AGONISTS |
| CA3188891A1 (en) | 2020-09-01 | 2022-01-13 | Fanglong Yang | Fused imidazole derivative, preparation method therefor, and medical use thereof |
| TWI843104B (zh) | 2021-05-20 | 2024-05-21 | 美商美國禮來大藥廠 | 類升糖素肽1受體促效劑 |
| WO2023011539A1 (zh) * | 2021-08-04 | 2023-02-09 | 上海翰森生物医药科技有限公司 | 环烯类衍生物调节剂、其制备方法和应用 |
| WO2023029380A1 (zh) | 2021-08-30 | 2023-03-09 | 杭州德睿智药科技有限公司 | 作为glp1r激动剂的新型芳醚取代杂环类化合物 |
| US20240374587A1 (en) | 2021-09-08 | 2024-11-14 | Shionogi & Co., Ltd. | Medicine for prevention and treatment of diseases linked to anti-obesity activity |
| PT4408840T (pt) | 2021-09-27 | 2025-10-07 | Terns Pharmaceuticals Inc | Ácidos benzimidazolocarboxílicos como agonistas de glp-1r |
| MX2024004131A (es) | 2021-10-05 | 2024-04-22 | Astrazeneca Ab | Ciertos 2,5-diazabiciclo[4.2.0]octanos como moduladores del receptor de glp-1. |
| US20250115612A1 (en) | 2021-10-05 | 2025-04-10 | Astrazeneca Ab | Certain 2,5-diazabicyclo[4.2.0]octanes and octahydrofuro[3,4-b]pyrazines as glp-1 receptor modulators |
| WO2023057414A1 (en) | 2021-10-05 | 2023-04-13 | Astrazeneca Ab | Certain octahydrofuro[3,4- b]pyrazines as glp-1 receptor modulators |
| CN118401519A (zh) | 2021-10-25 | 2024-07-26 | 拓臻制药公司 | 作为glp-1r激动剂的化合物 |
| US20250042882A1 (en) | 2021-12-16 | 2025-02-06 | Astrazeneca Ab | Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators |
| WO2023111144A1 (en) | 2021-12-16 | 2023-06-22 | Astrazeneca Ab | Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators |
| CN119095843A (zh) | 2022-02-23 | 2024-12-06 | 拓臻制药公司 | 作为glp-1r激动剂的化合物 |
| AU2023225875A1 (en) * | 2022-02-28 | 2024-09-26 | Ascletis Bioscience Co., Ltd. | Glp-1r modulating compounds |
| US20250250269A1 (en) * | 2022-04-14 | 2025-08-07 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| EP4562006A1 (en) * | 2022-07-27 | 2025-06-04 | Carmot Therapeutics, Inc. | N-heterocylic gpcr receptor agonists, pharmaceutical compositions comprising the same, and methods for their use |
| EP4592285A1 (en) | 2022-09-22 | 2025-07-30 | Shionogi & Co., Ltd. | Fused ring compound having glp-1 receptor agonist effect |
| WO2024102625A1 (en) | 2022-11-11 | 2024-05-16 | Eli Lilly And Company | Glucagon-like peptide 1 receptor agonists |
| KR20250085816A (ko) | 2022-11-16 | 2025-06-12 | 일라이 릴리 앤드 캄파니 | 글루카곤-유사 펩티드 1 수용체 효능제 |
| US20240368120A1 (en) * | 2023-03-29 | 2024-11-07 | Terns Pharmaceuticals, Inc. | Compounds as glp-1r agonists |
| EP4568664B1 (en) | 2023-04-07 | 2026-04-01 | Terns Pharmaceuticals, Inc. | Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating obesity |
| TW202504600A (zh) * | 2023-07-04 | 2025-02-01 | 大陸商杭州中美華東製藥有限公司 | Glp1r激動劑及其中間體的製備方法 |
| CN120981457A (zh) | 2023-09-14 | 2025-11-18 | 歌礼制药(中国)有限公司 | Glp-1r激动剂及其治疗方法 |
| TW202521534A (zh) | 2023-11-24 | 2025-06-01 | 香港商歌禮製藥(中國)有限公司 | Glp-1r 激動劑及其治療方法 |
| WO2025158275A1 (en) | 2024-01-24 | 2025-07-31 | Pfizer Inc. | Combination therapy using glucose-dependent insulinotropic polypeptide receptor antagonist compounds and glp-1 receptor agonist compounds |
| TW202600132A (zh) | 2024-03-08 | 2026-01-01 | 美商安尼波那生物公司 | 用於治療肥胖症及提高減重之方法 |
| WO2025252098A1 (zh) * | 2024-06-05 | 2025-12-11 | 杭州中美华东制药有限公司 | Glp-1受体激动剂的口服药物组合物及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7777051B2 (en) * | 2003-05-13 | 2010-08-17 | Icagen, Inc. | Asymmetric benzimidazoles and related compounds as potassium channel modulators |
| CL2009001214A1 (es) * | 2008-05-19 | 2010-12-31 | Schering Corp | Compuestos derivados de heterociclo, moduladores de serina proteasas composicion fa<rmacaeutica que los comprende; y su uso en el tratamiento de trastornos tromboembolicos |
| WO2010065674A1 (en) * | 2008-12-03 | 2010-06-10 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| US8420655B2 (en) * | 2009-12-04 | 2013-04-16 | Boehringer Ingelheim International Gmbh | Benzimidazole inhibitors of leukotriene production |
| WO2011149856A1 (en) * | 2010-05-24 | 2011-12-01 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| KR102314286B1 (ko) * | 2016-12-16 | 2021-10-21 | 화이자 인코포레이티드 | Glp-1 수용체 작용제 및 이의 용도 |
| US11136324B2 (en) * | 2017-03-03 | 2021-10-05 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Substituted imidazoles as apoptosis signal regulating kinase 1 inhibitors |
| US10934279B2 (en) * | 2018-06-13 | 2021-03-02 | Pfizer Inc. | GLP-1 receptor agonists and uses thereof |
| DK3806855T5 (da) * | 2018-06-15 | 2023-05-22 | Pfizer | GLP-1-receptoragonister og anvendelser deraf |
| MA54555A (fr) * | 2018-11-22 | 2021-09-29 | Qilu Regor Therapeutics Inc | Agonistes de glp-1r et leurs utilisations |
| EP3953344A4 (en) * | 2019-04-12 | 2023-08-09 | Qilu Regor Therapeutics Inc. | GLP-IR AGONISTS AND THEIR USES |
| WO2021018023A1 (zh) * | 2019-08-01 | 2021-02-04 | 济南泰达领创医药技术有限公司 | 小分子glp-1受体调节剂 |
| EP4048664A1 (en) * | 2019-10-25 | 2022-08-31 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
-
2021
- 2021-10-13 EP EP21879450.1A patent/EP4229050A4/en active Pending
- 2021-10-13 WO PCT/CN2021/123619 patent/WO2022078407A1/en not_active Ceased
- 2021-10-13 US US18/248,857 patent/US20230391760A1/en active Pending
- 2021-10-13 CN CN202180083383.1A patent/CN116547279A/zh active Pending
- 2021-10-13 JP JP2023522411A patent/JP2023546055A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023546055A5 (https=) | ||
| JP2023546054A5 (https=) | ||
| JP2023537501A5 (https=) | ||
| JP2023524493A5 (https=) | ||
| JP2023515404A5 (https=) | ||
| JP2023538949A5 (https=) | ||
| JP2023540558A5 (https=) | ||
| JP2023540609A5 (https=) | ||
| JP2023513272A5 (https=) | ||
| US10501456B2 (en) | Therapeutic agents for the treatment of HBV infection | |
| KR100967070B1 (ko) | 아세트산 아닐리드 유도체를 유효성분으로 하는 과활동방광 치료제 | |
| CN102316872B (zh) | 治疗肥胖症和糖尿病的胆汁酸再循环抑制剂 | |
| JP4860698B2 (ja) | 因子Ｘａ阻害剤としての新規なシクロアルカンカルボキシアミド | |
| US20230201185A1 (en) | Treatment of type 2 diabetes or obesity or overweight with 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof | |
| TWI222971B (en) | Antagonists of MCP-1 function and methods of use thereof | |
| JP2025506473A5 (https=) | ||
| RU2680248C1 (ru) | Комбинация, содержащая новое производное 3-(4-(бензилокси)фенил)гекс-4-иновой кислоты и другой активный ингредиент, для активирования фермента рецептора g-белка 40 | |
| JP2025508812A (ja) | Ｇｌｐ－１ｒアゴニストとしての化合物 | |
| US20150252034A1 (en) | Benzoxazolinone compounds with selective activity in voltage-gated sodium channels | |
| CN1183413A (zh) | 一种噻唑烷衍生物及其制药应用 | |
| US8802664B2 (en) | Benzazole derivatives as histamine H4 receptor ligands | |
| TW202227421A (zh) | Ｇｌｐ－１ｒ促效劑的晶型及其用途 | |
| KR20120046188A (ko) | 신규 화합물, 약제학적 조성물 및 이에 관련된 방법 | |
| JP2009501776A (ja) | 遊離脂肪酸に起因した障害におけるチアゾール誘導体およびアナログの使用 | |
| KR20070045272A (ko) | 2-페닐피리딘 유도체 |