JP2023542724A5 - - Google Patents
Info
- Publication number
- JP2023542724A5 JP2023542724A5 JP2023519504A JP2023519504A JP2023542724A5 JP 2023542724 A5 JP2023542724 A5 JP 2023542724A5 JP 2023519504 A JP2023519504 A JP 2023519504A JP 2023519504 A JP2023519504 A JP 2023519504A JP 2023542724 A5 JP2023542724 A5 JP 2023542724A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- carboxamide
- indazole
- imidazo
- pyrazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063084059P | 2020-09-28 | 2020-09-28 | |
| US63/084,059 | 2020-09-28 | ||
| PCT/IB2021/058794 WO2022064458A1 (en) | 2020-09-28 | 2021-09-27 | Indazoles as hematopoietic progenitor kinase 1 (hpk1) inhibitors and methods of using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023542724A JP2023542724A (ja) | 2023-10-11 |
| JP2023542724A5 true JP2023542724A5 (https=) | 2024-10-07 |
Family
ID=80821021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023519504A Pending JP2023542724A (ja) | 2020-09-28 | 2021-09-27 | 造血前駆細胞キナーゼ１（ｈｐｋ１）阻害剤としてのインダゾールおよびその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11834467B2 (https=) |
| EP (1) | EP4217358A4 (https=) |
| JP (1) | JP2023542724A (https=) |
| KR (1) | KR20230104143A (https=) |
| CN (2) | CN114599651B (https=) |
| AU (1) | AU2021347913A1 (https=) |
| CA (1) | CA3193865A1 (https=) |
| IL (1) | IL301244A (https=) |
| MX (1) | MX2023003631A (https=) |
| TW (1) | TWI908894B (https=) |
| WO (2) | WO2022064459A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022064459A1 (en) * | 2020-09-28 | 2022-03-31 | 1ST Biotherapeutics, Inc. | Indazoles as hematopoietic progenitor kinase 1 (hpk1) inhibitors and methods of using same |
| EP4499643A4 (en) * | 2022-03-25 | 2026-01-28 | 1St Biotherapeutics Inc | INDAZOLES USED AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS AND THEIR METHODS OF USE |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20070978A1 (es) * | 2006-02-14 | 2007-11-15 | Novartis Ag | COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks) |
| TW200911798A (en) | 2007-08-02 | 2009-03-16 | Amgen Inc | PI3 kinase modulators and methods of use |
| US8993580B2 (en) * | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
| WO2010008847A2 (en) | 2008-06-24 | 2010-01-21 | Takeda Pharmaceutical Company Limited | Pi3k/m tor inhibitors |
| US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
| PL2716157T3 (pl) | 2008-12-08 | 2017-06-30 | Gilead Connecticut, Inc. | Imidazopirazynowe inhibitory Syk |
| WO2010100144A1 (en) * | 2009-03-04 | 2010-09-10 | Merck Serono S.A. | Fused bicyclic compounds as inhibitors for pi3 kinase |
| BRPI1014572B8 (pt) | 2009-04-16 | 2022-07-19 | Fundacion Centro Nac De Investigaciones Oncologicas Carlos Iii | Imidazopirazinas para uso como inibidores de cinase |
| US9073927B2 (en) | 2010-01-22 | 2015-07-07 | Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii | Inhibitors of PI3 kinase |
| WO2012052745A1 (en) | 2010-10-21 | 2012-04-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Combinations of pi3k inhibitors with a second anti -tumor agent |
| AR086042A1 (es) | 2011-04-28 | 2013-11-13 | Galapagos Nv | Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica |
| WO2013130855A1 (en) | 2012-03-02 | 2013-09-06 | Takeda Pharmaceutical Company Limited | Indazole derivatives |
| PL236355B1 (pl) * | 2015-04-02 | 2021-01-11 | Celon Pharma Spolka Akcyjna | Pochodne 7-(morfolin-4-ylo)pirazolo[1,5-α]pirymidyny jako inhibitory kinazy PI3 |
| MA42456B1 (fr) * | 2015-06-25 | 2021-06-30 | Univ Health Network | Inhibiteurs de hpk1 et leurs procédés d'utilisation |
| CN115819417A (zh) * | 2016-09-09 | 2023-03-21 | 因赛特公司 | 作为hpk1调节剂的吡唑并吡啶衍生物及其用于治疗癌症的用途 |
| AU2018244935A1 (en) * | 2017-03-30 | 2019-08-15 | F. Hoffmann-La Roche Ag | Naphthyridines as inhibitors of HPK1 |
| AU2018346051B2 (en) | 2017-10-02 | 2022-11-10 | 1st Biotherapeutics Inc. | Benzothiazol compounds and methods using the same for treating neurodegenerative disorders |
| CN109721620B (zh) * | 2017-10-27 | 2022-05-13 | 药捷安康(南京)科技股份有限公司 | Hpk1抑制剂及其用途 |
| EP3707138B1 (en) * | 2017-11-06 | 2022-07-13 | Bristol-Myers Squibb Company | Isofuranone compounds useful as hpk1 inhibitors |
| EP3877371A4 (en) * | 2018-11-07 | 2022-07-27 | Dana-Farber Cancer Institute, Inc. | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF |
| AU2020224401A1 (en) * | 2019-02-22 | 2021-10-14 | 1ST Biotherapeutics, Inc. | Imidazopyridinyl compounds and use thereof for treatment of neurodegenerative disorders |
| WO2022064459A1 (en) * | 2020-09-28 | 2022-03-31 | 1ST Biotherapeutics, Inc. | Indazoles as hematopoietic progenitor kinase 1 (hpk1) inhibitors and methods of using same |
-
2021
- 2021-09-27 WO PCT/IB2021/058795 patent/WO2022064459A1/en not_active Ceased
- 2021-09-27 AU AU2021347913A patent/AU2021347913A1/en active Pending
- 2021-09-27 JP JP2023519504A patent/JP2023542724A/ja active Pending
- 2021-09-27 TW TW110135855A patent/TWI908894B/zh active
- 2021-09-27 MX MX2023003631A patent/MX2023003631A/es unknown
- 2021-09-27 EP EP21871811.2A patent/EP4217358A4/en active Pending
- 2021-09-27 US US17/485,653 patent/US11834467B2/en active Active
- 2021-09-27 CN CN202180003282.9A patent/CN114599651B/zh active Active
- 2021-09-27 IL IL301244A patent/IL301244A/en unknown
- 2021-09-27 KR KR1020237014773A patent/KR20230104143A/ko active Pending
- 2021-09-27 US US17/485,711 patent/US11649255B2/en active Active
- 2021-09-27 WO PCT/IB2021/058794 patent/WO2022064458A1/en not_active Ceased
- 2021-09-27 CN CN202180003294.1A patent/CN114599653B/zh active Active
- 2021-09-27 CA CA3193865A patent/CA3193865A1/en active Pending
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