JP2023540797A5 - - Google Patents
Info
- Publication number
- JP2023540797A5 JP2023540797A5 JP2023516057A JP2023516057A JP2023540797A5 JP 2023540797 A5 JP2023540797 A5 JP 2023540797A5 JP 2023516057 A JP2023516057 A JP 2023516057A JP 2023516057 A JP2023516057 A JP 2023516057A JP 2023540797 A5 JP2023540797 A5 JP 2023540797A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- nucleic acid
- endonuclease
- acid editing
- manipulated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063077057P | 2020-09-11 | 2020-09-11 | |
| US63/077,057 | 2020-09-11 | ||
| US202163222351P | 2021-07-15 | 2021-07-15 | |
| US63/222,351 | 2021-07-15 | ||
| PCT/US2021/049962 WO2022056324A1 (en) | 2020-09-11 | 2021-09-10 | Base editing enzymes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023540797A JP2023540797A (ja) | 2023-09-26 |
| JP2023540797A5 true JP2023540797A5 (enExample) | 2024-09-13 |
Family
ID=80629930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023516057A Pending JP2023540797A (ja) | 2020-09-11 | 2021-09-10 | 塩基編集酵素 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US12286654B2 (enExample) |
| EP (1) | EP4211234A4 (enExample) |
| JP (1) | JP2023540797A (enExample) |
| KR (1) | KR20230062873A (enExample) |
| AU (1) | AU2021339819A1 (enExample) |
| CA (1) | CA3192224A1 (enExample) |
| GB (1) | GB2605340B (enExample) |
| MX (1) | MX2023002913A (enExample) |
| WO (1) | WO2022056324A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021178933A2 (en) | 2020-03-06 | 2021-09-10 | Metagenomi Ip Technologies, Llc | Class ii, type v crispr systems |
| AU2015330699B2 (en) | 2014-10-10 | 2021-12-02 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| AU2019265019B2 (en) | 2018-05-11 | 2025-11-06 | Beam Therapeutics Inc. | Methods of substituting pathogenic amino acids using programmable base editor systems |
| EP3847254A4 (en) | 2018-09-07 | 2022-08-10 | Beam Therapeutics Inc. | COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM |
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| AU2020215730A1 (en) | 2019-01-31 | 2021-07-29 | Beam Therapeutics Inc. | Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors |
| CN120174005A (zh) | 2019-02-13 | 2025-06-20 | 比姆医疗股份有限公司 | 具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞 |
| EP4034138A4 (en) | 2019-09-27 | 2024-07-31 | Beam Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS |
| WO2021202568A1 (en) * | 2020-03-31 | 2021-10-07 | Metagenomi Ip Technologies, Llc | Class ii, type ii crispr systems |
| JP2023540797A (ja) | 2020-09-11 | 2023-09-26 | メタゲノミ，インコーポレイテッド | 塩基編集酵素 |
| CA3196831A1 (en) | 2020-09-25 | 2022-03-31 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| CA3205865A1 (en) * | 2021-01-22 | 2022-07-28 | Brian C. Thomas | Novel engineered and chimeric nucleases |
| AU2022335499A1 (en) | 2021-08-27 | 2024-02-22 | Metagenomi Therapeutics, Inc. | Enzymes with ruvc domains |
| WO2023081855A1 (en) * | 2021-11-05 | 2023-05-11 | Metagenomi, Inc. | Base editing enzymes |
| AU2022396533A1 (en) | 2021-11-24 | 2024-05-02 | Metagenomi Therapeutics, Inc. | Endonuclease systems |
| CN121241133A (zh) * | 2023-03-31 | 2025-12-30 | 阿伯生物技术公司 | Crispr核酸酶多肽和包含此类crispr核酸酶多肽的基因编辑系统 |
| WO2025003344A1 (en) * | 2023-06-28 | 2025-01-02 | Alia Therapeutics Srl | Type ii cas proteins and applications thereof |
| WO2025106894A1 (en) * | 2023-11-15 | 2025-05-22 | Profluent Bio Inc. | Adenine deaminases and compositions, systems, and methods thereof |
| WO2025240372A1 (en) * | 2024-05-13 | 2025-11-20 | Metagenomi, Inc. | Compositions and methods for editing t cells |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110214183A (zh) * | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| US11192929B2 (en) | 2016-12-08 | 2021-12-07 | Regents Of The University Of Minnesota | Site-specific DNA base editing using modified APOBEC enzymes |
| EP3572525A4 (en) | 2017-01-17 | 2020-09-30 | Institute for Basic Science | PROCEDURE FOR IDENTIFYING AN OFF-TARGET BASIC EDITING SITE BY BREAKING A SINGLE DNA STRAND |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| EP3617311B1 (en) * | 2017-03-30 | 2024-11-20 | Kyoto University | Method for inducing exon skipping by genome editing |
| US9982279B1 (en) * | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| KR102761791B1 (ko) * | 2017-06-26 | 2025-02-05 | 더 브로드 인스티튜트, 인코퍼레이티드 | 표적화된 핵산 편집을 위한 crispr/cas-아데닌 데아미나아제 기반 조성물, 시스템 및 방법 |
| JP2021506251A (ja) * | 2017-12-14 | 2021-02-22 | クリスパー セラピューティクス アーゲー | 新規ｒｎａプログラム可能エンドヌクレアーゼ系、ならびにゲノム編集および他の適用におけるその使用 |
| US11946040B2 (en) * | 2019-02-04 | 2024-04-02 | The General Hospital Corporation | Adenine DNA base editor variants with reduced off-target RNA editing |
| US20220298494A1 (en) | 2019-02-14 | 2022-09-22 | Metagenomi Ip Technologies, Llc | Enzymes with ruvc domains |
| CA3241703C (en) | 2019-02-14 | 2026-02-24 | Metagenomi Therapeutics, Inc. | Enzymes with ruvc domains |
| WO2021097118A1 (en) | 2019-11-12 | 2021-05-20 | The Broad Institute, Inc. | Small type ii cas proteins and methods of use thereof |
| WO2021202568A1 (en) * | 2020-03-31 | 2021-10-07 | Metagenomi Ip Technologies, Llc | Class ii, type ii crispr systems |
| GB2700205B (en) | 2020-09-11 | 2026-04-15 | Metagenomi Therapeutics Inc | Base editing enzymes |
| JP2023540797A (ja) | 2020-09-11 | 2023-09-26 | メタゲノミ，インコーポレイテッド | 塩基編集酵素 |
| WO2023081855A1 (en) * | 2021-11-05 | 2023-05-11 | Metagenomi, Inc. | Base editing enzymes |
-
2021
- 2021-09-10 JP JP2023516057A patent/JP2023540797A/ja active Pending
- 2021-09-10 KR KR1020237012244A patent/KR20230062873A/ko active Pending
- 2021-09-10 EP EP21867718.5A patent/EP4211234A4/en active Pending
- 2021-09-10 WO PCT/US2021/049962 patent/WO2022056324A1/en not_active Ceased
- 2021-09-10 GB GB2209534.3A patent/GB2605340B/en active Active
- 2021-09-10 CA CA3192224A patent/CA3192224A1/en active Pending
- 2021-09-10 MX MX2023002913A patent/MX2023002913A/es unknown
- 2021-09-10 AU AU2021339819A patent/AU2021339819A1/en active Pending
-
2022
- 2022-06-15 US US17/841,082 patent/US12286654B2/en active Active
-
2023
- 2023-03-07 US US18/180,009 patent/US20230348876A1/en active Pending
- 2023-05-31 US US18/326,440 patent/US20230374482A1/en active Pending
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