JP2023519953A5 - - Google Patents
Info
- Publication number
- JP2023519953A5 JP2023519953A5 JP2022559475A JP2022559475A JP2023519953A5 JP 2023519953 A5 JP2023519953 A5 JP 2023519953A5 JP 2022559475 A JP2022559475 A JP 2022559475A JP 2022559475 A JP2022559475 A JP 2022559475A JP 2023519953 A5 JP2023519953 A5 JP 2023519953A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- nuclease system
- manipulated
- endonuclease
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024144487A JP7785139B2 (ja) | 2020-03-31 | 2024-08-26 | クラス２のｉｉ型ｃｒｉｓｐｒシステム |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063003159P | 2020-03-31 | 2020-03-31 | |
| US63/003,159 | 2020-03-31 | ||
| US202063116149P | 2020-11-19 | 2020-11-19 | |
| US63/116,149 | 2020-11-19 | ||
| PCT/US2021/024945 WO2021202568A1 (en) | 2020-03-31 | 2021-03-30 | Class ii, type ii crispr systems |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024144487A Division JP7785139B2 (ja) | 2020-03-31 | 2024-08-26 | クラス２のｉｉ型ｃｒｉｓｐｒシステム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023519953A JP2023519953A (ja) | 2023-05-15 |
| JP2023519953A5 true JP2023519953A5 (enExample) | 2024-04-10 |
| JP7546689B2 JP7546689B2 (ja) | 2024-09-06 |
Family
ID=77929138
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022559475A Active JP7546689B2 (ja) | 2020-03-31 | 2021-03-30 | クラス２のｉｉ型ｃｒｉｓｐｒシステム |
| JP2024144487A Active JP7785139B2 (ja) | 2020-03-31 | 2024-08-26 | クラス２のｉｉ型ｃｒｉｓｐｒシステム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024144487A Active JP7785139B2 (ja) | 2020-03-31 | 2024-08-26 | クラス２のｉｉ型ｃｒｉｓｐｒシステム |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11946039B2 (enExample) |
| EP (2) | EP4632066A3 (enExample) |
| JP (2) | JP7546689B2 (enExample) |
| KR (2) | KR20250051161A (enExample) |
| CN (1) | CN116096877B (enExample) |
| AU (1) | AU2021248800A1 (enExample) |
| CA (1) | CA3177051A1 (enExample) |
| ES (1) | ES3055163T3 (enExample) |
| GB (1) | GB2608292B (enExample) |
| MX (1) | MX2022012110A (enExample) |
| WO (1) | WO2021202568A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3204496A1 (en) | 2014-10-10 | 2017-08-16 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| CN113728097A (zh) * | 2019-02-14 | 2021-11-30 | 宏基因组学知识产权技术有限责任公司 | 具有ruvc结构域的酶 |
| US10913941B2 (en) | 2019-02-14 | 2021-02-09 | Metagenomi Ip Technologies, Llc | Enzymes with RuvC domains |
| US20230340537A1 (en) * | 2020-01-17 | 2023-10-26 | The Broad Institute, Inc. | Small type ii-d cas proteins and methods of use thereof |
| CA3177051A1 (en) | 2020-03-31 | 2021-10-07 | Metagenomi, Inc. | Class ii, type ii crispr systems |
| CA3192224A1 (en) * | 2020-09-11 | 2022-03-17 | Jyun-Liang LIN | Base editing enzymes |
| CN119452085A (zh) | 2021-08-27 | 2025-02-14 | 宏基因组学公司 | 具有ruvc结构域的酶 |
| MX2024005505A (es) | 2021-11-05 | 2024-05-23 | Metagenomi Inc | Enzimas de edicion de bases. |
| WO2023097262A1 (en) * | 2021-11-24 | 2023-06-01 | Metagenomi, Inc. | Endonuclease systems |
| KR20240110603A (ko) * | 2021-11-24 | 2024-07-15 | 메타지노미, 인크. | 엔도뉴클레아제 시스템 |
| ES2970263B2 (es) * | 2022-10-21 | 2024-10-11 | Univ Alicante | PROTEINA ENDONUCLEASA Cas9 Y SISTEMA CRISPR-Cas ASOCIADO |
| WO2024192291A1 (en) | 2023-03-15 | 2024-09-19 | Renagade Therapeutics Management Inc. | Delivery of gene editing systems and methods of use thereof |
| WO2024206759A1 (en) * | 2023-03-31 | 2024-10-03 | Arbor Biotechnologies, Inc. | Crispr nuclease polypeptides and gene editing systems comprising such |
| CN121241133A (zh) * | 2023-03-31 | 2025-12-30 | 阿伯生物技术公司 | Crispr核酸酶多肽和包含此类crispr核酸酶多肽的基因编辑系统 |
| WO2024206825A2 (en) * | 2023-03-31 | 2024-10-03 | Aera Therapeutics, Inc. | Modified iscb nucleases, modified guide rnas, and uses thereof |
| WO2024233366A2 (en) * | 2023-05-05 | 2024-11-14 | Aera Therapeutics, Inc. | Modified cas9-iid nucleases and uses thereof |
| JP2026519501A (ja) * | 2023-05-23 | 2026-06-16 | メタゲノミ セラピューティクス，インク． | エンドヌクレアーゼ系 |
| WO2025007044A1 (en) * | 2023-06-28 | 2025-01-02 | The University Of Chicago | Methods and compositions comprising iscb variants |
| EP4771154A2 (en) | 2023-09-01 | 2026-07-08 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| WO2025054425A1 (en) * | 2023-09-08 | 2025-03-13 | Arbor Biotechnologies, Inc. | Reverse transcription-mediated gene editing systems and uses thereof |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291438B1 (en) | 1993-02-24 | 2001-09-18 | Jui H. Wang | Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use |
| US5858988A (en) | 1993-02-24 | 1999-01-12 | Wang; Jui H. | Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use |
| US9637739B2 (en) | 2012-03-20 | 2017-05-02 | Vilnius University | RNA-directed DNA cleavage by the Cas9-crRNA complex |
| DK3363902T3 (da) | 2012-12-06 | 2020-01-02 | Sigma Aldrich Co Llc | Crispr-baseret genommodifikation og -regulering |
| CN105209621B (zh) | 2012-12-12 | 2021-05-25 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| PT2931898E (pt) | 2012-12-12 | 2016-06-16 | Harvard College | Manipulação e otimização de sistemas, métodos e composições para manipulação de sequências com domínios funcionais |
| US10584358B2 (en) | 2013-10-30 | 2020-03-10 | North Carolina State University | Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri |
| WO2015089364A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Crystal structure of a crispr-cas system, and uses thereof |
| WO2016073990A2 (en) | 2014-11-07 | 2016-05-12 | Editas Medicine, Inc. | Methods for improving crispr/cas-mediated genome-editing |
| AU2016226077B2 (en) | 2015-03-03 | 2021-12-23 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases with altered PAM specificity |
| MX2017014560A (es) | 2015-05-15 | 2018-03-01 | Pioneer Hi Bred Int | Caracterizacion rapida de sistemas de endonucleasa cas, secuencias pam y elementos arn de guia. |
| US10392607B2 (en) | 2015-06-03 | 2019-08-27 | The Regents Of The University Of California | Cas9 variants and methods of use thereof |
| US20160362667A1 (en) | 2015-06-10 | 2016-12-15 | Caribou Biosciences, Inc. | CRISPR-Cas Compositions and Methods |
| EP3929287A3 (en) | 2015-06-18 | 2022-04-13 | The Broad Institute, Inc. | Crispr enzyme mutations reducing off-target effects |
| EP3426780A1 (en) | 2016-03-11 | 2019-01-16 | Pioneer Hi-Bred International, Inc. | Novel cas9 systems and methods of use |
| WO2018035250A1 (en) | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Methods for identifying class 2 crispr-cas systems |
| CA3038982A1 (en) * | 2016-09-30 | 2018-04-05 | The Regents Of The University Of California | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
| WO2018074979A1 (en) | 2016-10-17 | 2018-04-26 | Nanyang Technological University | Truncated crispr-cas proteins for dna targeting |
| WO2018209712A1 (en) | 2017-05-19 | 2018-11-22 | Tsinghua University | Engineering of a minimal sacas9 crispr/cas system for gene editing and transcriptional regulation optimized by enhanced guide rna |
| MX2019011215A (es) | 2017-03-24 | 2020-02-12 | Curevac Ag | Ácidos nucleicos que codifican proteínas asociadas a crispr y usos de los mismos. |
| CN110892069B (zh) | 2017-03-30 | 2024-02-09 | 国立大学法人京都大学 | 基于基因组编辑的外显子跳跃诱导方法 |
| US10011849B1 (en) | 2017-06-23 | 2018-07-03 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| US9982279B1 (en) | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| WO2019161290A1 (en) | 2018-02-15 | 2019-08-22 | Sigma-Aldrich Co. Llc | Engineered cas9 systems for eukaryotic genome modification |
| KR20200124702A (ko) | 2018-02-23 | 2020-11-03 | 파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 | 신규한 cas9 오르소로그 |
| WO2020055941A1 (en) | 2018-09-13 | 2020-03-19 | Excision Biotherapeutics, Inc. | Compositions and methods for excision with single grna |
| US20220220460A1 (en) | 2019-02-14 | 2022-07-14 | Metagenomi Ip Technologies, Llc | Enzymes with ruvc domains |
| CN113728097A (zh) | 2019-02-14 | 2021-11-30 | 宏基因组学知识产权技术有限责任公司 | 具有ruvc结构域的酶 |
| US10913941B2 (en) | 2019-02-14 | 2021-02-09 | Metagenomi Ip Technologies, Llc | Enzymes with RuvC domains |
| KR20240007322A (ko) * | 2019-02-14 | 2024-01-16 | 메타지노미, 인크. | Ruvc 도메인이 존재하는 효소 |
| US20220235340A1 (en) | 2019-05-20 | 2022-07-28 | The Broad Institute, Inc. | Novel crispr-cas systems and uses thereof |
| US20220403357A1 (en) * | 2019-11-12 | 2022-12-22 | The Broad Institute, Inc. | Small type ii cas proteins and methods of use thereof |
| WO2021202559A1 (en) * | 2020-03-31 | 2021-10-07 | Metagenomi Ip Technologies, Llc | Class ii, type ii crispr systems |
| CA3177051A1 (en) | 2020-03-31 | 2021-10-07 | Metagenomi, Inc. | Class ii, type ii crispr systems |
| WO2021226369A1 (en) | 2020-05-08 | 2021-11-11 | Metagenomi Ip Technologies, Llc | Enzymes with ruvc domains |
| CN116096892A (zh) | 2020-05-08 | 2023-05-09 | 宏基因组学公司 | 具有RuvC结构域的酶 |
| CA3192224A1 (en) * | 2020-09-11 | 2022-03-17 | Jyun-Liang LIN | Base editing enzymes |
| CN116867897A (zh) * | 2020-09-11 | 2023-10-10 | 宏基因组学公司 | 碱基编辑酶 |
| EP4203993A4 (en) | 2020-10-23 | 2024-10-23 | The Broad Institute, Inc. | Reprogrammable iscb nucleases and uses thereof |
-
2021
- 2021-03-30 CA CA3177051A patent/CA3177051A1/en active Pending
- 2021-03-30 MX MX2022012110A patent/MX2022012110A/es unknown
- 2021-03-30 JP JP2022559475A patent/JP7546689B2/ja active Active
- 2021-03-30 KR KR1020257011372A patent/KR20250051161A/ko active Pending
- 2021-03-30 EP EP25194658.8A patent/EP4632066A3/en active Pending
- 2021-03-30 ES ES21779798T patent/ES3055163T3/es active Active
- 2021-03-30 GB GB2211839.2A patent/GB2608292B/en active Active
- 2021-03-30 EP EP21779798.4A patent/EP4127156B1/en active Active
- 2021-03-30 KR KR1020227037087A patent/KR102794727B1/ko active Active
- 2021-03-30 AU AU2021248800A patent/AU2021248800A1/en active Pending
- 2021-03-30 CN CN202180039435.5A patent/CN116096877B/zh active Active
- 2021-03-30 WO PCT/US2021/024945 patent/WO2021202568A1/en not_active Ceased
-
2022
- 2022-07-05 US US17/857,923 patent/US11946039B2/en active Active
-
2024
- 2024-02-07 US US18/435,779 patent/US20240309356A1/en active Pending
- 2024-08-26 JP JP2024144487A patent/JP7785139B2/ja active Active