EP3924482A4 - Enzymes with ruvc domains - Google Patents
Enzymes with ruvc domains Download PDFInfo
- Publication number
- EP3924482A4 EP3924482A4 EP20756259.6A EP20756259A EP3924482A4 EP 3924482 A4 EP3924482 A4 EP 3924482A4 EP 20756259 A EP20756259 A EP 20756259A EP 3924482 A4 EP3924482 A4 EP 3924482A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- enzymes
- ruvc domains
- ruvc
- domains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cell Biology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962805878P | 2019-02-14 | 2019-02-14 | |
US201962805868P | 2019-02-14 | 2019-02-14 | |
US201962805899P | 2019-02-14 | 2019-02-14 | |
US201962874414P | 2019-07-15 | 2019-07-15 | |
PCT/US2020/018432 WO2020168291A1 (en) | 2019-02-14 | 2020-02-14 | Enzymes with ruvc domains |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3924482A1 EP3924482A1 (en) | 2021-12-22 |
EP3924482A4 true EP3924482A4 (en) | 2023-04-05 |
Family
ID=72045639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20756259.6A Pending EP3924482A4 (en) | 2019-02-14 | 2020-02-14 | Enzymes with ruvc domains |
Country Status (9)
Country | Link |
---|---|
US (1) | US20240117330A1 (en) |
EP (1) | EP3924482A4 (en) |
JP (3) | JP2022520428A (en) |
KR (2) | KR20240007322A (en) |
CN (2) | CN113728098A (en) |
AU (2) | AU2020223370B2 (en) |
CA (2) | CA3130135A1 (en) |
MX (2) | MX2021009886A (en) |
WO (1) | WO2020168291A1 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20240007322A (en) * | 2019-02-14 | 2024-01-16 | 메타지노미, 인크. | Enzymes with ruvc domains |
US10982200B2 (en) | 2019-02-14 | 2021-04-20 | Metagenomi Ip Technologies, Llc | Enzymes with RuvC domains |
GB2594339B (en) * | 2020-02-14 | 2023-02-08 | Metagenomi Inc | Enzymes with RUVC domains |
CA3174557A1 (en) | 2020-03-06 | 2021-09-10 | Metagenomi, Inc. | Class ii, type v crispr systems |
CN116096877A (en) * | 2020-03-31 | 2023-05-09 | 宏基因组学公司 | Class II type II CRISPR system |
WO2021226369A1 (en) * | 2020-05-08 | 2021-11-11 | Metagenomi Ip Technologies, Llc | Enzymes with ruvc domains |
GB2615901A (en) * | 2020-09-11 | 2023-08-23 | Metagenomi Inc | Base editing enzymes |
WO2022098681A2 (en) * | 2020-11-03 | 2022-05-12 | Caspr Biotech Corporation | Novel class 2 crispr-cas rna-guided endonucleases |
AU2022210762A1 (en) * | 2021-01-22 | 2023-08-24 | Metagenomi, Inc. | Novel engineered and chimeric nucleases |
WO2022159742A1 (en) * | 2021-01-22 | 2022-07-28 | Metagenomi, Inc | Novel engineered and chimeric nucleases |
JP2024517607A (en) * | 2021-04-30 | 2024-04-23 | メタゲノミ,インク. | Enzymes containing RUVC domains |
WO2023122663A2 (en) * | 2021-12-23 | 2023-06-29 | Mammoth Biosciences, Inc. | Effector proteins and methods of use |
WO2023194359A1 (en) * | 2022-04-04 | 2023-10-12 | Alia Therapeutics Srl | Compositions and methods for treatment of usher syndrome type 2a |
WO2023245141A2 (en) * | 2022-06-15 | 2023-12-21 | Beam Therapeutics Inc. | Compositions and methods for reducing complement activation |
WO2024056880A2 (en) * | 2022-09-16 | 2024-03-21 | Alia Therapeutics Srl | Enqp type ii cas proteins and applications thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018035250A1 (en) * | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Methods for identifying class 2 crispr-cas systems |
US20190264232A1 (en) * | 2018-02-23 | 2019-08-29 | Pioneer Hi-Bred International, Inc. | Novel cas9 orthologs |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3064585T3 (en) * | 2012-12-12 | 2020-04-27 | Broad Inst Inc | DESIGN AND OPTIMIZATION OF IMPROVED SYSTEMS, PROCEDURES AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION |
WO2016196655A1 (en) * | 2015-06-03 | 2016-12-08 | The Regents Of The University Of California | Cas9 variants and methods of use thereof |
WO2016205759A1 (en) * | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation |
KR20240007322A (en) | 2019-02-14 | 2024-01-16 | 메타지노미, 인크. | Enzymes with ruvc domains |
-
2020
- 2020-02-14 KR KR1020247000311A patent/KR20240007322A/en active Search and Examination
- 2020-02-14 MX MX2021009886A patent/MX2021009886A/en unknown
- 2020-02-14 CN CN202080028787.6A patent/CN113728098A/en active Pending
- 2020-02-14 JP JP2021547336A patent/JP2022520428A/en not_active Ceased
- 2020-02-14 CA CA3130135A patent/CA3130135A1/en active Pending
- 2020-02-14 KR KR1020217028874A patent/KR102623312B1/en active IP Right Grant
- 2020-02-14 WO PCT/US2020/018432 patent/WO2020168291A1/en unknown
- 2020-02-14 CN CN202310441977.6A patent/CN116515797A/en active Pending
- 2020-02-14 EP EP20756259.6A patent/EP3924482A4/en active Pending
- 2020-02-14 CA CA3241703A patent/CA3241703A1/en active Pending
- 2020-02-14 AU AU2020223370A patent/AU2020223370B2/en active Active
-
2021
- 2021-08-16 MX MX2023006575A patent/MX2023006575A/en unknown
-
2023
- 2023-06-15 US US18/335,481 patent/US20240117330A1/en active Pending
- 2023-07-17 AU AU2023206079A patent/AU2023206079A1/en active Pending
- 2023-09-08 JP JP2023146414A patent/JP7502537B2/en active Active
-
2024
- 2024-06-05 JP JP2024091759A patent/JP2024133476A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018035250A1 (en) * | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Methods for identifying class 2 crispr-cas systems |
US20190264232A1 (en) * | 2018-02-23 | 2019-08-29 | Pioneer Hi-Bred International, Inc. | Novel cas9 orthologs |
Non-Patent Citations (9)
Title |
---|
ANONYMOUS: "GSP:BGS65773", 17 October 2019 (2019-10-17), XP055968889, Retrieved from the Internet <URL:http://ibis.internal.epo.org/exam/dbfetch.jsp?id=GSP:BGS65773> [retrieved on 20221007] * |
ANONYMOUS: "GSP:BGS65777", 29 August 2019 (2019-08-29), XP055968896, Retrieved from the Internet <URL:http://ibis.internal.epo.org/exam/dbfetch.jsp?id=GSP:BGS65777> [retrieved on 20221007] * |
KOONIN EUGENE V ET AL: "Diversity, classification and evolution of CRISPR-Cas systems", CURRENT OPINION IN MICROBIOLOGY, vol. 37, 9 June 2017 (2017-06-09), pages 67 - 78, XP085276922, ISSN: 1369-5274, DOI: 10.1016/J.MIB.2017.05.008 * |
See also references of WO2020168291A1 * |
SERGEY SHMAKOV ET AL: "Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems", MOLECULAR CELL, vol. 60, no. 3, 1 November 2015 (2015-11-01), AMSTERDAM, NL, pages 385 - 397, XP055267512, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2015.10.008 * |
SHMAKOV SERGEY ET AL: "Diversity and evolution of class 2 CRISPR-Cas systems", NATURE REVIEWS. MICROBIOLOGY, NATURE PUBLISHING GROUP, ENGLAND, vol. 15, no. 3, 1 March 2017 (2017-03-01), pages 169 - 182, XP002767857, ISSN: 1740-1534, DOI: 10.1038/NRMICRO.2016.184 * |
UNIPROTKB/TREMBL: "A0A1F0KNW4 . A0A1F0KNW4_9MICC HNHc domain-containing protein . Rothia sp. HMSC066H02", 15 February 2017 (2017-02-15), XP055968869, Retrieved from the Internet <URL:https://rest.uniprot.org/uniprotkb/A0A1F0KNW4.txt> [retrieved on 20221007] * |
UNIPROTKB/TREMBL: "A0A1F0PN46 . A0A1F0PN46_9MICC HNH Cas9-type domain-containing protein . Rothia sp. HMSC076D04", 15 February 2017 (2017-02-15), XP055968835, Retrieved from the Internet <URL:https://rest.uniprot.org/uniprotkb/A0A1F0PN46.txt> [retrieved on 20221007] * |
UNIPROTKB/TREMBL: "A0A1S1DAD0 . A0A1S1DAD0_9MICC HNH Cas9-type domain-containing protein . Rothia sp. HMSC065C03", 12 April 2017 (2017-04-12), XP055968878, Retrieved from the Internet <URL:https://rest.uniprot.org/uniprotkb/A0A1S1DAD0.txt> [retrieved on 20221007] * |
Also Published As
Publication number | Publication date |
---|---|
AU2023206079A1 (en) | 2023-08-10 |
AU2020223370A1 (en) | 2021-10-07 |
CA3130135A1 (en) | 2020-08-20 |
KR20210139254A (en) | 2021-11-22 |
EP3924482A1 (en) | 2021-12-22 |
WO2020168291A1 (en) | 2020-08-20 |
AU2020223370B2 (en) | 2023-04-20 |
CA3241703A1 (en) | 2020-08-20 |
JP2024133476A (en) | 2024-10-02 |
JP7502537B2 (en) | 2024-06-18 |
CN113728098A (en) | 2021-11-30 |
US20240117330A1 (en) | 2024-04-11 |
MX2021009886A (en) | 2021-10-13 |
JP2023179468A (en) | 2023-12-19 |
CN116515797A (en) | 2023-08-01 |
MX2023006575A (en) | 2023-06-16 |
KR102623312B1 (en) | 2024-01-09 |
JP2022520428A (en) | 2022-03-30 |
KR20240007322A (en) | 2024-01-16 |
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