JP2023515670A5 - - Google Patents

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Publication number
JP2023515670A5
JP2023515670A5 JP2022552549A JP2022552549A JP2023515670A5 JP 2023515670 A5 JP2023515670 A5 JP 2023515670A5 JP 2022552549 A JP2022552549 A JP 2022552549A JP 2022552549 A JP2022552549 A JP 2022552549A JP 2023515670 A5 JP2023515670 A5 JP 2023515670A5
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JP
Japan
Prior art keywords
sequence
protein
aptamer
nucleic acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022552549A
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English (en)
Japanese (ja)
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JP2023515670A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/020513 external-priority patent/WO2021178432A1/en
Publication of JP2023515670A publication Critical patent/JP2023515670A/ja
Publication of JP2023515670A5 publication Critical patent/JP2023515670A5/ja
Pending legal-status Critical Current

Links

JP2022552549A 2020-03-03 2021-03-02 キロ塩基スケールでのrnaガイドゲノムリコンビニアリング Pending JP2023515670A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062984618P 2020-03-03 2020-03-03
US62/984,618 2020-03-03
US202163146447P 2021-02-05 2021-02-05
US63/146,447 2021-02-05
PCT/US2021/020513 WO2021178432A1 (en) 2020-03-03 2021-03-02 Rna-guided genome recombineering at kilobase scale

Publications (2)

Publication Number Publication Date
JP2023515670A JP2023515670A (ja) 2023-04-13
JP2023515670A5 true JP2023515670A5 (enExample) 2024-03-07

Family

ID=77614129

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022552549A Pending JP2023515670A (ja) 2020-03-03 2021-03-02 キロ塩基スケールでのrnaガイドゲノムリコンビニアリング

Country Status (11)

Country Link
US (1) US20230091242A1 (enExample)
EP (1) EP4114845A4 (enExample)
JP (1) JP2023515670A (enExample)
KR (1) KR20220151175A (enExample)
CN (1) CN115667283A (enExample)
AU (1) AU2021231769A1 (enExample)
BR (1) BR112022017196A2 (enExample)
CA (1) CA3173526A1 (enExample)
IL (1) IL296057A (enExample)
MX (1) MX2022010835A (enExample)
WO (1) WO2021178432A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023034925A1 (en) * 2021-09-01 2023-03-09 The Board Of Trustees Of The Leland Stanford Junior University Rna-guided genome recombineering at kilobase scale
WO2023154892A1 (en) * 2022-02-10 2023-08-17 Possible Medicines Llc Rna-guided genome recombineering at kilobase scale
IL314544A (en) * 2022-02-10 2024-09-01 Univ Leland Stanford Junior Ribonucleic acid-guided genome recombination engineering at the scale of thousands of bases
WO2024168253A1 (en) * 2023-02-10 2024-08-15 Possible Medicines Llc Delivery of an rna guided recombination system
WO2024168265A1 (en) * 2023-02-10 2024-08-15 Possible Medicines Llc Aav delivery of rna guided recombination system
CN117025670A (zh) * 2023-03-13 2023-11-10 苏州金唯智生物科技有限公司 一种检测CRISPR-Cas产生的DNA双链断裂位点的方法
CN120555441B (zh) * 2025-05-29 2026-04-17 西北农林科技大学 基于CtIP蛋白提高CRISPR/Cas9介导的外源基因整合效率的DNA适配体及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2337027T3 (es) * 1997-12-05 2010-04-20 Europaisches Laboratorium Fur Molekularbiologie (Embl) Nuevo metodo de clonacion de dna basado en el sistema de recombinacion rece-rect de e. coli.
US10760064B2 (en) * 2013-03-15 2020-09-01 The General Hospital Corporation RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
US9322037B2 (en) * 2013-09-06 2016-04-26 President And Fellows Of Harvard College Cas9-FokI fusion proteins and uses thereof
AU2015298571B2 (en) * 2014-07-30 2020-09-03 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
AU2016226077B2 (en) * 2015-03-03 2021-12-23 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases with altered PAM specificity
WO2016205759A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
EP3957731A1 (en) * 2015-07-15 2022-02-23 Rutgers, The State University of New Jersey Nuclease-independent targeted gene editing platform and uses thereof
WO2019089910A1 (en) * 2017-11-01 2019-05-09 Ohio State Innovation Foundation Highly compact cas9-based transcriptional regulators for in vivo gene regulation
US11293019B2 (en) * 2017-12-22 2022-04-05 Gflas Life Sciences, Inc. Chimeric genome engineering molecules and methods
WO2023034925A1 (en) * 2021-09-01 2023-03-09 The Board Of Trustees Of The Leland Stanford Junior University Rna-guided genome recombineering at kilobase scale

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