CN115667283A - Rna指导的千碱基规模基因组重组工程 - Google Patents

Rna指导的千碱基规模基因组重组工程 Download PDF

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CN115667283A
CN115667283A CN202180033011.8A CN202180033011A CN115667283A CN 115667283 A CN115667283 A CN 115667283A CN 202180033011 A CN202180033011 A CN 202180033011A CN 115667283 A CN115667283 A CN 115667283A
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ala
glu
sequence
leu
protein
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丛乐
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Leland Stanford Junior University
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Leland Stanford Junior University
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CN202180033011.8A 2020-03-03 2021-03-02 Rna指导的千碱基规模基因组重组工程 Pending CN115667283A (zh)

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US202062984618P 2020-03-03 2020-03-03
US62/984,618 2020-03-03
US202163146447P 2021-02-05 2021-02-05
US63/146,447 2021-02-05
PCT/US2021/020513 WO2021178432A1 (en) 2020-03-03 2021-03-02 Rna-guided genome recombineering at kilobase scale

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120555441A (zh) * 2025-05-29 2025-08-29 西北农林科技大学 基于CtIP蛋白提高CRISPR/Cas9介导的外源基因整合效率的DNA适配体及其应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2024002482A (es) * 2021-09-01 2024-09-19 Univ Leland Stanford Junior Recombinacion del genoma guiada por arn en escala de kilobase.
WO2023154892A1 (en) * 2022-02-10 2023-08-17 Possible Medicines Llc Rna-guided genome recombineering at kilobase scale
JP2025505732A (ja) * 2022-02-10 2025-02-28 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー キロ塩基スケールでのｒｎａガイドゲノムリコンビニアリング
WO2024168253A1 (en) * 2023-02-10 2024-08-15 Possible Medicines Llc Delivery of an rna guided recombination system
WO2024168265A1 (en) * 2023-02-10 2024-08-15 Possible Medicines Llc Aav delivery of rna guided recombination system

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US6509156B1 (en) * 1997-12-05 2003-01-21 Europaisches Laboratorium Fur Molekularoiologie (Embl) DNA cloning method relying on the E. coli recE/recT recombination system
US9322037B2 (en) * 2013-09-06 2016-04-26 President And Fellows Of Harvard College Cas9-FokI fusion proteins and uses thereof
US10077453B2 (en) * 2014-07-30 2018-09-18 President And Fellows Of Harvard College CAS9 proteins including ligand-dependent inteins
KR20230156800A (ko) * 2015-03-03 2023-11-14 더 제너럴 하스피탈 코포레이션 변경된 PAM 특이성을 갖는 조작된 CRISPR-Cas9 뉴클레아제
WO2016205759A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
JP7044373B2 (ja) * 2015-07-15 2022-03-30 ラトガース，ザ ステート ユニバーシティ オブ ニュージャージー ヌクレアーゼ非依存的な標的化遺伝子編集プラットフォームおよびその用途
WO2019089910A1 (en) * 2017-11-01 2019-05-09 Ohio State Innovation Foundation Highly compact cas9-based transcriptional regulators for in vivo gene regulation
EP3728589A4 (en) * 2017-12-22 2021-11-03 G+Flas Life Sciences CHEMICAL GENOMIC ENGINEERING MOLECULES AND PROCESSES
MX2024002482A (es) * 2021-09-01 2024-09-19 Univ Leland Stanford Junior Recombinacion del genoma guiada por arn en escala de kilobase.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120555441A (zh) * 2025-05-29 2025-08-29 西北农林科技大学 基于CtIP蛋白提高CRISPR/Cas9介导的外源基因整合效率的DNA适配体及其应用

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BR112022017196A2 (pt) 2022-10-25
WO2021178432A9 (en) 2021-10-28
WO2021178432A1 (en) 2021-09-10
EP4114845A1 (en) 2023-01-11
CA3173526A1 (en) 2021-09-10
EP4114845A4 (en) 2024-03-06
US20230091242A1 (en) 2023-03-23
KR20220151175A (ko) 2022-11-14
JP2023515670A (ja) 2023-04-13
MX2022010835A (es) 2022-09-29
IL296057A (en) 2022-10-01

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