JP2023520504A5 - - Google Patents
Info
- Publication number
- JP2023520504A5 JP2023520504A5 JP2022560154A JP2022560154A JP2023520504A5 JP 2023520504 A5 JP2023520504 A5 JP 2023520504A5 JP 2022560154 A JP2022560154 A JP 2022560154A JP 2022560154 A JP2022560154 A JP 2022560154A JP 2023520504 A5 JP2023520504 A5 JP 2023520504A5
- Authority
- JP
- Japan
- Prior art keywords
- cas12i2
- polypeptide
- sequence
- mutant
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (37)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063003090P | 2020-03-31 | 2020-03-31 | |
| US202063002999P | 2020-03-31 | 2020-03-31 | |
| US202063003064P | 2020-03-31 | 2020-03-31 | |
| US63/003,064 | 2020-03-31 | ||
| US63/003,090 | 2020-03-31 | ||
| US63/002,999 | 2020-03-31 | ||
| US202063012007P | 2020-04-17 | 2020-04-17 | |
| US63/012,007 | 2020-04-17 | ||
| US202063026562P | 2020-05-18 | 2020-05-18 | |
| US202063026277P | 2020-05-18 | 2020-05-18 | |
| US202063026523P | 2020-05-18 | 2020-05-18 | |
| US202063026606P | 2020-05-18 | 2020-05-18 | |
| US63/026,523 | 2020-05-18 | ||
| US63/026,606 | 2020-05-18 | ||
| US63/026,277 | 2020-05-18 | ||
| US63/026,562 | 2020-05-18 | ||
| US202063063819P | 2020-08-10 | 2020-08-10 | |
| US202063063859P | 2020-08-10 | 2020-08-10 | |
| US202063063831P | 2020-08-10 | 2020-08-10 | |
| US202063063879P | 2020-08-10 | 2020-08-10 | |
| US63/063,819 | 2020-08-10 | ||
| US63/063,879 | 2020-08-10 | ||
| US63/063,831 | 2020-08-10 | ||
| US63/063,859 | 2020-08-10 | ||
| US202063085752P | 2020-09-30 | 2020-09-30 | |
| US202063085792P | 2020-09-30 | 2020-09-30 | |
| US202063085895P | 2020-09-30 | 2020-09-30 | |
| US202063085862P | 2020-09-30 | 2020-09-30 | |
| US63/085,792 | 2020-09-30 | ||
| US63/085,895 | 2020-09-30 | ||
| US63/085,752 | 2020-09-30 | ||
| US63/085,862 | 2020-09-30 | ||
| US202163147850P | 2021-02-10 | 2021-02-10 | |
| US202163147968P | 2021-02-10 | 2021-02-10 | |
| US63/147,968 | 2021-02-10 | ||
| US63/147,850 | 2021-02-10 | ||
| PCT/US2021/025257 WO2021202800A1 (en) | 2020-03-31 | 2021-03-31 | Compositions comprising a cas12i2 variant polypeptide and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023520504A JP2023520504A (ja) | 2023-05-17 |
| JP2023520504A5 true JP2023520504A5 (enExample) | 2024-04-11 |
Family
ID=75640000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022560154A Pending JP2023520504A (ja) | 2020-03-31 | 2021-03-31 | Ｃａｓ１２ｉ２変異体ポリペプチドを含む組成物及びその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230332119A1 (enExample) |
| EP (1) | EP4127154A1 (enExample) |
| JP (1) | JP2023520504A (enExample) |
| KR (1) | KR20230009379A (enExample) |
| CN (2) | CN121380024A (enExample) |
| AU (1) | AU2021249119A1 (enExample) |
| BR (1) | BR112022019713A2 (enExample) |
| CA (1) | CA3177749A1 (enExample) |
| CO (1) | CO2022015170A2 (enExample) |
| IL (1) | IL296791A (enExample) |
| MX (1) | MX2022012189A (enExample) |
| WO (1) | WO2021202800A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015330699B2 (en) | 2014-10-10 | 2021-12-02 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| US20230193243A1 (en) * | 2020-05-29 | 2023-06-22 | Arbor Biotechnologies, Inc. | Compositions comprising a cas12i2 polypeptide and uses thereof |
| EP4237557A1 (en) * | 2020-10-30 | 2023-09-06 | Arbor Biotechnologies, Inc. | Compositions comprising an rna guide targeting pdcd1 and uses thereof |
| EP4347818A2 (en) * | 2021-06-01 | 2024-04-10 | Arbor Biotechnologies, Inc. | Gene editing systems comprising a crispr nuclease and uses thereof |
| IL308803A (en) | 2021-06-04 | 2024-01-01 | Arbor Biotechnologies Inc | Gene editing systems comprising guide RNA targeting hydroxy acid oxidase 1 (HAO1) and uses thereof |
| US20230034581A1 (en) * | 2021-06-04 | 2023-02-02 | Arbor Biotechnologies, Inc. | Gene editing systems comprising an rna guide targeting lactate dehydrogenase a (ldha) and uses thereof |
| WO2022256619A2 (en) | 2021-06-04 | 2022-12-08 | Arbor Biotechnologies, Inc. | Gene editing systems comprising an rna guide targeting transthyretin (ttr) and uses thereof |
| WO2023018856A1 (en) | 2021-08-11 | 2023-02-16 | Arbor Biotechnologies, Inc. | Gene editing systems comprising an rna guide targeting polypyrimidine tract binding protein 1 (ptbp1) and uses thereof |
| US20230203539A1 (en) | 2021-08-11 | 2023-06-29 | Arbor Biotechnologies, Inc. | Gene editing systems comprising an rna guide targeting stathmin 2 (stmn2) and uses thereof |
| WO2023034475A1 (en) | 2021-09-01 | 2023-03-09 | Arbor Biotechnologies, Inc. | Cells modified by a cas12i polypeptide |
| EP4399293A4 (en) * | 2021-09-10 | 2025-10-15 | Arbor Biotechnologies Inc | COMPOSITIONS COMPRISING A CAS12I POLYPEPTIDE AND USES THEREOF |
| CA3237337A1 (en) * | 2021-11-02 | 2023-05-11 | Huidagene Therapeutics (Singapore) Pte. Ltd. | Novel crispr-cas12i systems and uses thereof |
| TW202334421A (zh) * | 2021-11-05 | 2023-09-01 | 美商阿伯生物技術公司 | 包含靶向ciita之rna引導之組合物及其用途 |
| WO2023122433A1 (en) | 2021-12-22 | 2023-06-29 | Arbor Biotechnologies, Inc. | Gene editing systems targeting hydroxyacid oxidase 1 (hao1) and lactate dehydrogenase a (ldha) |
| CN118749029A (zh) * | 2022-01-24 | 2024-10-08 | 辉大(上海)生物科技有限公司 | 新型CRISPR-Cas12i系统及其用途 |
| CN118995668A (zh) * | 2022-04-25 | 2024-11-22 | 辉大基因治疗(新加坡)私人有限公司 | 新型CRISPR-Cas12i系统及其用途 |
| EP4627083A1 (en) | 2022-11-30 | 2025-10-08 | Arbor Biotechnologies, Inc. | Reverse transcriptase-mediated genetic editing of transthyretin (ttr) and uses thereof |
| KR20250151430A (ko) | 2023-02-15 | 2025-10-21 | 아버 바이오테크놀로지스, 인크. | 스타스민 2(stmn2) 전사체에서 비정상적인 스플라이싱을 억제하는 유전자 편집 방법 |
| WO2025096594A2 (en) | 2023-10-30 | 2025-05-08 | Allogene Therapeutics, Inc. | Cells expressing anti-cd19 chimeric antigen receptors and methods of use thereof |
| CN117431235A (zh) * | 2023-11-06 | 2024-01-23 | 微光基因(苏州)有限公司 | CRISPR-Cas系统及其应用 |
| WO2025147604A1 (en) | 2024-01-05 | 2025-07-10 | Arbor Biotechnologies, Inc. | Methods for treating primary hyperoxaluria via genetic editing of hydroxyacid oxidase 1 |
| WO2025171210A1 (en) | 2024-02-09 | 2025-08-14 | Arbor Biotechnologies, Inc. | Compositions and methods for gene editing via homology-mediated end joining |
| WO2026015829A2 (en) | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Small reverse transcriptases and gene editing systems comprising such |
| WO2026015832A2 (en) | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Reverse transcriptases and gene editing systems comprising such |
| CN120424908B (zh) * | 2025-07-10 | 2025-09-12 | 南京农业大学 | 一种基于LAMP与CRISPR/Cas的检测方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3031921B1 (en) | 2012-12-12 | 2025-03-12 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| CN105492611A (zh) * | 2013-06-17 | 2016-04-13 | 布罗德研究所有限公司 | 用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物 |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| WO2019178427A1 (en) * | 2018-03-14 | 2019-09-19 | Arbor Biotechnologies, Inc. | Novel crispr dna targeting enzymes and systems |
| JP7693552B2 (ja) * | 2019-02-13 | 2025-06-17 | ビーム セラピューティクス インク． | アデノシンデアミナーゼ塩基エディターおよびそれを用いて標的配列中の核酸塩基を改変する方法 |
| WO2024178144A1 (en) * | 2023-02-22 | 2024-08-29 | Prime Medicine, Inc. | Methods and compositions for editing nucleotide sequences |
-
2021
- 2021-03-31 CN CN202511379190.7A patent/CN121380024A/zh active Pending
- 2021-03-31 CA CA3177749A patent/CA3177749A1/en active Pending
- 2021-03-31 KR KR1020227037945A patent/KR20230009379A/ko active Pending
- 2021-03-31 BR BR112022019713A patent/BR112022019713A2/pt unknown
- 2021-03-31 EP EP21720912.1A patent/EP4127154A1/en active Pending
- 2021-03-31 MX MX2022012189A patent/MX2022012189A/es unknown
- 2021-03-31 WO PCT/US2021/025257 patent/WO2021202800A1/en not_active Ceased
- 2021-03-31 US US17/916,270 patent/US20230332119A1/en active Pending
- 2021-03-31 JP JP2022560154A patent/JP2023520504A/ja active Pending
- 2021-03-31 CN CN202180038904.1A patent/CN115698278B/zh active Active
- 2021-03-31 AU AU2021249119A patent/AU2021249119A1/en active Pending
- 2021-03-31 IL IL296791A patent/IL296791A/en unknown
-
2022
- 2022-10-25 CO CONC2022/0015170A patent/CO2022015170A2/es unknown
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