JP2023539828A - コール酸誘導体およびそのための出発物質を製造する方法 - Google Patents

コール酸誘導体およびそのための出発物質を製造する方法 Download PDF

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Publication number
JP2023539828A
JP2023539828A JP2023512277A JP2023512277A JP2023539828A JP 2023539828 A JP2023539828 A JP 2023539828A JP 2023512277 A JP2023512277 A JP 2023512277A JP 2023512277 A JP2023512277 A JP 2023512277A JP 2023539828 A JP2023539828 A JP 2023539828A
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formula
optionally substituted
compound
alkyl
oxy
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Japanese (ja)
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JP2023539828A5 (https=
Inventor
リード，ジェイ．，グレゴリー
レッディ，ジャヤチャンドラ，ピー．
ジェイ． ポール，バ－ナード
サマド ホセイン，スク
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サンドヒル ワン，エルエルシー
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Publication of JP2023539828A publication Critical patent/JP2023539828A/ja
Publication of JP2023539828A5 publication Critical patent/JP2023539828A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
JP2023512277A 2020-08-21 2021-08-11 コール酸誘導体およびそのための出発物質を製造する方法 Pending JP2023539828A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063068498P 2020-08-21 2020-08-21
US63/068,498 2020-08-21
PCT/US2021/045467 WO2022039983A2 (en) 2020-08-21 2021-08-11 Methods of making cholic acid derivatives and starting materials therefor

Publications (2)

Publication Number Publication Date
JP2023539828A true JP2023539828A (ja) 2023-09-20
JP2023539828A5 JP2023539828A5 (https=) 2024-08-20

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JP2023512277A Pending JP2023539828A (ja) 2020-08-21 2021-08-11 コール酸誘導体およびそのための出発物質を製造する方法

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Country Link
US (1) US11384116B2 (https=)
EP (1) EP4200311A4 (https=)
JP (1) JP2023539828A (https=)
CN (1) CN115884978A (https=)
AU (1) AU2021328142A1 (https=)
CA (1) CA3190433A1 (https=)
WO (1) WO2022039983A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250188113A1 (en) 2021-11-02 2025-06-12 Sandhill One, Llc High purity non-animal derived tudca
CN116836214B (zh) * 2022-03-25 2024-07-09 苏州恩泰新材料科技有限公司 一种7-酮石胆酸中间体的合成方法和应用
EP4506354A4 (en) * 2022-03-25 2026-05-06 Suzhou Entech New Material Tech Co Ltd 7-ketolithocholic acid intermediate, synthesis method therefor, and application thereof
CN115819491A (zh) * 2022-12-22 2023-03-21 江苏佳尔科药业集团股份有限公司 7-酮基石胆酸及熊去氧胆酸的合成方法

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WO2020128541A1 (en) * 2018-12-20 2020-06-25 Equip-Test Kft. Connector structure for connecting optical conduits, crimping device and push-out device therefor, and light-blocking element for a connector part

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IT1204429B (it) 1986-01-09 1989-03-01 Blaschim Spa Riduzione stereoselettiva in acidi biliari
US5595996A (en) 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
CN101018802A (zh) * 2004-07-13 2007-08-15 三菱化学株式会社 甾类化合物的制备方法
KR20070067078A (ko) 2004-07-13 2007-06-27 미쓰비시 가가꾸 가부시키가이샤 스테로이드 화합물의 제조 방법
KR101986195B1 (ko) 2009-11-30 2019-06-07 파마젤 게엠베하 신규한 ７β-히드록시스테로이드 데히드로게나제 및 그의 용도
US20130261317A1 (en) * 2010-09-27 2013-10-03 Kythera Biopharmaceuticals, Inc. Methods for preparing synthetic bile acids and compositions comprising the same
US10414791B2 (en) * 2015-07-30 2019-09-17 Intercept Pharmaceuticals, Inc Methods for preparation of bile acids and derivatives thereof
MX2018005520A (es) * 2015-11-06 2018-08-01 Intercept Pharmaceuticals Inc Metodos para preparacion de acido obeticolico y derivados de los mismos.
CN111072744B (zh) * 2019-12-03 2021-09-14 江苏佳尔科药业集团股份有限公司 一种以ba为原料合成熊去氧胆酸的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020128541A1 (en) * 2018-12-20 2020-06-25 Equip-Test Kft. Connector structure for connecting optical conduits, crimping device and push-out device therefor, and light-blocking element for a connector part

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARCH. PHARM. RES., vol. 32, JPN6025036939, 2009, pages 857 - 862, ISSN: 0005683327 *
STEROIDS, vol. 33, JPN6025036936, 1979, pages 693 - 718, ISSN: 0005683325 *
STEROIDS, vol. 58, JPN6025036938, 1993, pages 524 - 526, ISSN: 0005683326 *
TETRAHEDRON LETT., vol. 33, JPN6025036940, 1992, pages 3235 - 3236, ISSN: 0005683328 *

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Publication number Publication date
US20220056070A1 (en) 2022-02-24
EP4200311A2 (en) 2023-06-28
EP4200311A4 (en) 2024-11-20
CN115884978A (zh) 2023-03-31
WO2022039983A3 (en) 2022-03-31
AU2021328142A1 (en) 2023-03-16
WO2022039983A2 (en) 2022-02-24
CA3190433A1 (en) 2022-02-24
US11384116B2 (en) 2022-07-12

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