CN115884978A - 制备胆酸衍生物的方法及其原料 - Google Patents

制备胆酸衍生物的方法及其原料 Download PDF

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Publication number
CN115884978A
CN115884978A CN202180051142.9A CN202180051142A CN115884978A CN 115884978 A CN115884978 A CN 115884978A CN 202180051142 A CN202180051142 A CN 202180051142A CN 115884978 A CN115884978 A CN 115884978A
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CN
China
Prior art keywords
compound
formula
optionally substituted
alkyl
oxy
Prior art date
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Pending
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CN202180051142.9A
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English (en)
Chinese (zh)
Inventor
J·G·里德
J·P·雷迪
B·J·保罗
S·S·侯赛因
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Shashan No1 Co ltd
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Shashan No1 Co ltd
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Publication of CN115884978A publication Critical patent/CN115884978A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
CN202180051142.9A 2020-08-21 2021-08-11 制备胆酸衍生物的方法及其原料 Pending CN115884978A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063068498P 2020-08-21 2020-08-21
US63/068,498 2020-08-21
PCT/US2021/045467 WO2022039983A2 (en) 2020-08-21 2021-08-11 Methods of making cholic acid derivatives and starting materials therefor

Publications (1)

Publication Number Publication Date
CN115884978A true CN115884978A (zh) 2023-03-31

Family

ID=80269315

Family Applications (1)

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CN202180051142.9A Pending CN115884978A (zh) 2020-08-21 2021-08-11 制备胆酸衍生物的方法及其原料

Country Status (7)

Country Link
US (1) US11384116B2 (https=)
EP (1) EP4200311A4 (https=)
JP (1) JP2023539828A (https=)
CN (1) CN115884978A (https=)
AU (1) AU2021328142A1 (https=)
CA (1) CA3190433A1 (https=)
WO (1) WO2022039983A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115819491A (zh) * 2022-12-22 2023-03-21 江苏佳尔科药业集团股份有限公司 7-酮基石胆酸及熊去氧胆酸的合成方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250188113A1 (en) 2021-11-02 2025-06-12 Sandhill One, Llc High purity non-animal derived tudca
CN116836214B (zh) * 2022-03-25 2024-07-09 苏州恩泰新材料科技有限公司 一种7-酮石胆酸中间体的合成方法和应用
EP4506354A4 (en) * 2022-03-25 2026-05-06 Suzhou Entech New Material Tech Co Ltd 7-ketolithocholic acid intermediate, synthesis method therefor, and application thereof

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US20060252948A1 (en) * 2004-07-13 2006-11-09 Jun Takehara Production method of steroid compound
CN101018802A (zh) * 2004-07-13 2007-08-15 三菱化学株式会社 甾类化合物的制备方法
WO2012047495A2 (en) * 2010-09-27 2012-04-12 Kythera Biopharmaceuticals, Inc. Methods for preparing synthetic bile acids and compositions comprising the same
CN108025994A (zh) * 2015-07-30 2018-05-11 英特塞普特医药品公司 用于制备胆汁酸及其衍生物的方法
CN108348533A (zh) * 2015-11-06 2018-07-31 英特塞普特医药品公司 制备奥贝胆酸及其衍生物的方法
CN111072744A (zh) * 2019-12-03 2020-04-28 华东师范大学 一种以ba为原料合成熊去氧胆酸的方法

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IT1204429B (it) 1986-01-09 1989-03-01 Blaschim Spa Riduzione stereoselettiva in acidi biliari
US5595996A (en) 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
KR101986195B1 (ko) 2009-11-30 2019-06-07 파마젤 게엠베하 신규한 ７β-히드록시스테로이드 데히드로게나제 및 그의 용도
HUP1800439A2 (hu) * 2018-12-20 2020-06-29 Equip Test Kft Csatlakozószerkezet optikai vezetékek csatlakoztatására, valamint krimpelõ eszköz és kinyomó eszköz ahhoz

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060252948A1 (en) * 2004-07-13 2006-11-09 Jun Takehara Production method of steroid compound
CN101018802A (zh) * 2004-07-13 2007-08-15 三菱化学株式会社 甾类化合物的制备方法
WO2012047495A2 (en) * 2010-09-27 2012-04-12 Kythera Biopharmaceuticals, Inc. Methods for preparing synthetic bile acids and compositions comprising the same
CN108025994A (zh) * 2015-07-30 2018-05-11 英特塞普特医药品公司 用于制备胆汁酸及其衍生物的方法
CN108348533A (zh) * 2015-11-06 2018-07-31 英特塞普特医药品公司 制备奥贝胆酸及其衍生物的方法
CN111072744A (zh) * 2019-12-03 2020-04-28 华东师范大学 一种以ba为原料合成熊去氧胆酸的方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FANTIN, GIANCARLO 等: "Synthesis of 7- and 12-hydroxy- and 7, 12-dihydroxy-3-keto-5b-cholan-24-oic acids by reduction of 3, 7-, 3, 12- and 3, 7, 12-oxo derivatives", 《STEROIDS》, vol. 58, no. 11, 1 November 1993 (1993-11-01), pages 524 - 526 *
JIE WANG 等: "Synthesis of ursodeoxycholic acid from plant-source (20S)-21-hydroxy-20- methylpregn-4-en-3-one", 《STEROIDS》, vol. 157, 14 February 2020 (2020-02-14), pages 1 - 6, XP086083441, DOI: 10.1016/j.steroids.2020.108600 *
MAPPUS, E. 等: "Synthesis and stereochemistry of C-3- and C-7-linked (O-carboxymethyl)oximino- and hemisuccinamido derivatives of 5α-dihydrotestosterone", 《STEROIDS》, vol. 33, no. 6, 1 June 1979 (1979-06-01), pages 693 - 718, XP023430729, DOI: 10.1016/0039-128X(79)90117-X *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115819491A (zh) * 2022-12-22 2023-03-21 江苏佳尔科药业集团股份有限公司 7-酮基石胆酸及熊去氧胆酸的合成方法

Also Published As

Publication number Publication date
US20220056070A1 (en) 2022-02-24
EP4200311A2 (en) 2023-06-28
EP4200311A4 (en) 2024-11-20
WO2022039983A3 (en) 2022-03-31
AU2021328142A1 (en) 2023-03-16
JP2023539828A (ja) 2023-09-20
WO2022039983A2 (en) 2022-02-24
CA3190433A1 (en) 2022-02-24
US11384116B2 (en) 2022-07-12

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Application publication date: 20230331