|
US7198919B1
(en)
|
1983-04-25 |
2007-04-03 |
Genentech, Inc. |
Use of alpha factor sequences in yeast expression systems
|
|
US4569794A
(en)
|
1984-12-05 |
1986-02-11 |
Eli Lilly And Company |
Process for purifying proteins and compounds useful in such process
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5279833A
(en)
|
1990-04-04 |
1994-01-18 |
Yale University |
Liposomal transfection of nucleic acids into animal cells
|
|
US5439829A
(en)
|
1991-01-30 |
1995-08-08 |
Eli Lilly And Company |
Immobilization of biologically active molecules by changing the Oxidation state of a chelated transition metal ion
|
|
CA2113990A1
(en)
|
1991-07-26 |
1993-02-18 |
Frederick L. Moolten |
Cancer therapy utilizing malignant cells
|
|
US5283185A
(en)
|
1991-08-28 |
1994-02-01 |
University Of Tennessee Research Corporation |
Method for delivering nucleic acids into cells
|
|
IL104570A0
(en)
|
1992-03-18 |
1993-05-13 |
Yeda Res & Dev |
Chimeric genes and cells transformed therewith
|
|
US5320663A
(en)
|
1992-07-02 |
1994-06-14 |
E. I. Du Pont De Nemours And Company |
Method of obtaining lead and organolead from contaminated media using metal accumulating plants
|
|
US5334761A
(en)
|
1992-08-28 |
1994-08-02 |
Life Technologies, Inc. |
Cationic lipids
|
|
US5578475A
(en)
|
1993-07-12 |
1996-11-26 |
Life Technologies, Inc. |
Composition and methods for transfecting eukaryotic cells
|
|
US5631236A
(en)
|
1993-08-26 |
1997-05-20 |
Baylor College Of Medicine |
Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
|
|
US5650234A
(en)
|
1994-09-09 |
1997-07-22 |
Surface Engineering Technologies, Division Of Innerdyne, Inc. |
Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US7038032B2
(en)
*
|
2001-04-20 |
2006-05-02 |
Zymogenetics, Inc. |
Cytokine protein family
|
|
WO2003066002A2
(en)
|
2002-02-08 |
2003-08-14 |
University Of Medicine And Dentistry Of New Jersey |
IFN-a/b-INDEPENDENT MECHANISM OF ANTIVIRAL PROTECTION
|
|
US20060002935A1
(en)
|
2002-06-28 |
2006-01-05 |
Domantis Limited |
Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor
|
|
TW200607523A
(en)
|
2004-06-01 |
2006-03-01 |
Domantis Ltd |
Drug compositions, fusions and conjugates
|
|
MXPA06014067A
(es)
|
2004-06-04 |
2007-02-15 |
Genentech Inc |
Metodo para tratar lupus.
|
|
US7553932B1
(en)
|
2005-04-25 |
2009-06-30 |
La Jolla Institute For Allergy And Immunology |
Methods of treating viral infection with IL-10 receptor antagonists
|
|
DK2439273T3
(da)
|
2005-05-09 |
2019-06-03 |
Ono Pharmaceutical Co |
Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
|
|
PT1907424E
(pt)
|
2005-07-01 |
2015-10-09 |
Squibb & Sons Llc |
Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
US20080199460A1
(en)
|
2005-09-01 |
2008-08-21 |
Schering Corporation |
Use of IL-23 and IL-17 antagonists to treat autoimmune ocular inflammatory disease
|
|
TW200744634A
(en)
*
|
2006-02-21 |
2007-12-16 |
Wyeth Corp |
Methods of using antibodies against human IL-22
|
|
JP2009543579A
(ja)
|
2006-07-19 |
2009-12-10 |
ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア |
抗炎症反応のための標的としてのWSX−1/p28
|
|
NZ579251A
(en)
|
2007-02-28 |
2012-06-29 |
Schering Corp |
Engineered anti-il-23r antibodies
|
|
EP2650311A3
(en)
|
2007-11-27 |
2014-06-04 |
Ablynx N.V. |
Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
|
|
EP2262837A4
(en)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
|
WO2009154995A2
(en)
*
|
2008-05-27 |
2009-12-23 |
Kyowa Hakko Kirin Co., Ltd. |
Interleukin 10 receptor (il-10r) antibodies and methods of use
|
|
EP3255060A1
(en)
|
2008-12-09 |
2017-12-13 |
F. Hoffmann-La Roche AG |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
WO2010118243A2
(en)
|
2009-04-08 |
2010-10-14 |
Genentech, Inc. |
Use of il-27 antagonists to treat lupus
|
|
WO2010142551A2
(en)
|
2009-06-12 |
2010-12-16 |
Ablynx N.V. |
Single variable domain (vhh) antibodies to cytokines of the il-17 receptor family
|
|
GB201005063D0
(en)
|
2010-03-25 |
2010-05-12 |
Ucb Pharma Sa |
Biological products
|
|
WO2011051327A2
(en)
|
2009-10-30 |
2011-05-05 |
Novartis Ag |
Small antibody-like single chain proteins
|
|
UY33492A
(es)
|
2010-07-09 |
2012-01-31 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
US20120225081A1
(en)
|
2010-09-03 |
2012-09-06 |
Boehringer Ingelheim International Gmbh |
Vegf-binding molecules
|
|
US20120201746A1
(en)
|
2010-12-22 |
2012-08-09 |
Abbott Laboratories |
Half immunoglobulin binding proteins and uses thereof
|
|
EP2714738B1
(en)
|
2011-05-24 |
2018-10-10 |
Zyngenia, Inc. |
Multivalent and monovalent multispecific complexes and their uses
|
|
US20140155581A1
(en)
|
2011-07-06 |
2014-06-05 |
Medimmune, Llc |
Methods For Making Multimeric Polypeptides
|
|
WO2013059299A1
(en)
|
2011-10-17 |
2013-04-25 |
The Uab Research Foundation |
Antibodies for interferon subtypes and interferon/interferon receptor ternary complex and uses thereof
|
|
US10131710B2
(en)
*
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
CN103396482B
(zh)
|
2013-05-17 |
2016-08-10 |
东南大学 |
一种前白蛋白纳米抗体、其编码序列及应用
|
|
CN105722859B
(zh)
|
2013-07-25 |
2021-05-07 |
西托姆克斯治疗公司 |
多特异性抗体、多特异性可活化抗体及其使用方法
|
|
CN115160441A
(zh)
|
2013-09-26 |
2022-10-11 |
埃博灵克斯股份有限公司 |
双特异性纳米抗体
|
|
WO2015175957A1
(en)
|
2014-05-16 |
2015-11-19 |
Baylor Research Institute |
Methods and compositions for treating autoimmune and inflammatory conditions
|
|
AU2015366284B2
(en)
|
2014-12-19 |
2021-07-22 |
Ablynx N.V. |
Cysteine linked nanobody dimers
|
|
LT3611192T
(lt)
|
2015-05-13 |
2025-06-25 |
Ablynx N.V. |
T ląstelių rekrutingo polipeptidai tcr alfa/beta reaktyvumo pagrindu
|
|
US9708412B2
(en)
|
2015-05-21 |
2017-07-18 |
Harpoon Therapeutics, Inc. |
Trispecific binding proteins and methods of use
|
|
PT3328894T
(pt)
|
2015-08-06 |
2019-02-13 |
Agency Science Tech & Res |
Anticorpos de cadeia comum gama/il2rbeta
|
|
CN106883297B
(zh)
|
2015-12-16 |
2019-12-13 |
苏州康宁杰瑞生物科技有限公司 |
基于ch3结构域的异二聚体分子、其制备方法及用途
|
|
CN107216389B
(zh)
|
2016-03-18 |
2022-03-29 |
和迈生物科技有限公司 |
抗pd-l1纳米抗体及其编码序列和用途
|
|
CN107400166A
(zh)
|
2016-05-19 |
2017-11-28 |
苏州康宁杰瑞生物科技有限公司 |
针对ctla4的单域抗体及其衍生蛋白
|
|
WO2018182935A1
(en)
|
2017-03-31 |
2018-10-04 |
The Board Of Trustees Of The Leland Stanford Junior University |
Synthekine compositions and methods of use
|
|
GB201707238D0
(en)
|
2017-05-05 |
2017-06-21 |
Univ Oxford Innovation Ltd |
Composition
|
|
EP3634465A4
(en)
|
2017-05-25 |
2021-01-20 |
The Broad Institute, Inc. |
LYMPHOCYTE ANTIGEN CD5 SIMILAR (CD5L) MONOMER, HOMODIMER AND INTERLEUKIN 12B (P40) HETERODIMER ANTAGONISTS AND METHOD OF USE THEREOF
|
|
AR111837A1
(es)
|
2017-05-30 |
2019-08-21 |
Agrivida Inc |
Plantas transgénicas inmunomoduladoras y métodos relacionados
|
|
KR20240141853A
(ko)
|
2017-08-03 |
2024-09-27 |
신톡스, 인크. |
자가면역 질환의 치료를 위한 사이토카인 접합체
|
|
CN117050184A
(zh)
|
2017-12-28 |
2023-11-14 |
南京传奇生物科技有限公司 |
针对tigit的单域抗体和其变体
|
|
EP3850013A4
(en)
|
2018-09-10 |
2022-10-05 |
Nanjing Legend Biotech Co., Ltd. |
SINGLE DOMAIN ANTIBODIES AGAINST CLL1 AND USES THEREOF
|
|
WO2020144164A1
(en)
|
2019-01-07 |
2020-07-16 |
Bactolife Aps |
Pathogen binding proteins
|
|
GB201903767D0
(en)
|
2019-03-19 |
2019-05-01 |
Quadrucept Bio Ltd |
Multimers, tetramers & octamers
|
|
CN111018985B
(zh)
|
2019-12-06 |
2021-06-18 |
南京融捷康生物科技有限公司 |
针对牛血清白蛋白bsa的单域抗体的应用
|