JP2023532679A5 - - Google Patents
Info
- Publication number
- JP2023532679A5 JP2023532679A5 JP2022580235A JP2022580235A JP2023532679A5 JP 2023532679 A5 JP2023532679 A5 JP 2023532679A5 JP 2022580235 A JP2022580235 A JP 2022580235A JP 2022580235 A JP2022580235 A JP 2022580235A JP 2023532679 A5 JP2023532679 A5 JP 2023532679A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- molecule
- xyl
- rha
- saponin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2025905 | 2020-06-24 | ||
| NL2025905 | 2020-06-24 | ||
| PCT/NL2021/050391 WO2021261995A1 (en) | 2020-06-24 | 2021-06-22 | Combination of an antibody-drug conjugate and an antibody-saponin conjugate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023532679A JP2023532679A (ja) | 2023-07-31 |
| JP2023532679A5 true JP2023532679A5 (https=) | 2024-07-01 |
Family
ID=72179118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022580235A Pending JP2023532679A (ja) | 2020-06-24 | 2021-06-22 | 抗体－薬物コンジュゲート及び抗体－サポニンコンジュゲートの組合せ |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230248845A1 (https=) |
| EP (1) | EP4171642A1 (https=) |
| JP (1) | JP2023532679A (https=) |
| KR (1) | KR20230044195A (https=) |
| CN (1) | CN116249553A (https=) |
| AU (1) | AU2021297636A1 (https=) |
| CA (1) | CA3183883A1 (https=) |
| IL (1) | IL299360A (https=) |
| WO (1) | WO2021261995A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022164316A1 (en) | 2021-01-26 | 2022-08-04 | Sapreme Technologies B.V. | Semicarbazone-based saponin conjugate |
| WO2023038517A1 (en) | 2021-09-09 | 2023-03-16 | Sapreme Technologies B.V. | Semicarbazone-based saponin conjugate |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7256257B2 (en) * | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| EP1623715B1 (en) * | 2004-07-13 | 2012-09-19 | Charité - Universitätsmedizin Berlin | A composition comprising a pharmacologically active agent coupled to a target cell specific component, and a saponin |
| KR102256410B1 (ko) * | 2008-04-08 | 2021-05-26 | 슬로안-케테링인스티튜트퍼캔서리서치 | 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도 |
| JP6685924B2 (ja) * | 2014-04-11 | 2020-04-22 | メディミューン，エルエルシー | システイン操作抗体を含むコンジュゲート化合物 |
| SG11202106603UA (en) * | 2018-12-21 | 2021-07-29 | Sapreme Tech Bv | Biologically active cluster of molecules |
| ES3056941T3 (en) * | 2019-07-25 | 2026-02-25 | Sapreme Tech Bv | Saponin derivatives with improved therapeutic window |
| EP4003425A2 (en) * | 2019-07-25 | 2022-06-01 | Sapreme Technologies B.V. | Bioactive saponin linked to a functional moiety |
-
2021
- 2021-06-22 KR KR1020237002640A patent/KR20230044195A/ko not_active Withdrawn
- 2021-06-22 WO PCT/NL2021/050391 patent/WO2021261995A1/en not_active Ceased
- 2021-06-22 IL IL299360A patent/IL299360A/en unknown
- 2021-06-22 EP EP21734543.8A patent/EP4171642A1/en active Pending
- 2021-06-22 US US18/012,760 patent/US20230248845A1/en active Pending
- 2021-06-22 JP JP2022580235A patent/JP2023532679A/ja active Pending
- 2021-06-22 CN CN202180051961.3A patent/CN116249553A/zh active Pending
- 2021-06-22 CA CA3183883A patent/CA3183883A1/en active Pending
- 2021-06-22 AU AU2021297636A patent/AU2021297636A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3897739B1 (en) | Saponin conjugates | |
| JP2023532040A5 (https=) | ||
| JP2023532679A5 (https=) | ||
| US20230277612A1 (en) | Saponin derivatives for use in medicine | |
| EP4003427B1 (en) | Saponin derivatives with improved therapeutic window | |
| JP2022542075A5 (https=) | ||
| JP7652808B2 (ja) | Ｖｈｈを含むａｄｃ又はａｏｃと、サポニン又はリガンド－サポニンコンジュゲートとを含む組み合わせ | |
| CN116249553A (zh) | 抗体-药物缀合物和抗体-皂苷缀合物的组合 | |
| US20250295800A1 (en) | Conjugate of a single domain antibody, a saponin and an effector molecule, pharmaceutical composition comprising the same, therapeutic use of said pharmaceutical composition | |
| JP2023542500A5 (https=) | ||
| JP2023532003A5 (https=) | ||
| WO2023048233A1 (ja) | 腫瘍細胞を死滅させるための医薬 | |
| US20240327829A1 (en) | Conjugate of saponin, oligonucleotide and galnac | |
| JP2023541762A (ja) | 単一ドメイン抗体、サポニン及びエフェクター分子のコンジュゲート、それを含む医薬組成物、前記医薬組成物の治療的使用 | |
| EP4640692A2 (en) | Semicarbazone-based saponin conjugate | |
| HK40111389A (en) | Saponin conjugates | |
| HK40130827A (en) | Combination comprising an adc or an aoc comprising a vhh, and a saponin or a ligand-saponin conjugate | |
| HK40074297B (en) | Saponin derivatives with improved therapeutic window | |
| HK40074297A (en) | Saponin derivatives with improved therapeutic window | |
| HK40077637B (en) | Improved antibody-oligonucleotide conjugate | |
| HK40063153A (en) | Saponin conjugates | |
| HK40063151A (en) | Biologically active cluster of molecules | |
| NZ778372B2 (en) | Biologically active cluster of molecules |