JP2023524599A - 二官能性化合物を製造する方法、二官能性化合物の超高純度形態、及びそれらを含む剤形 - Google Patents

二官能性化合物を製造する方法、二官能性化合物の超高純度形態、及びそれらを含む剤形 Download PDF

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JP2023524599A
JP2023524599A JP2022567864A JP2022567864A JP2023524599A JP 2023524599 A JP2023524599 A JP 2023524599A JP 2022567864 A JP2022567864 A JP 2022567864A JP 2022567864 A JP2022567864 A JP 2022567864A JP 2023524599 A JP2023524599 A JP 2023524599A
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compound
impurity
ultra
purity
pure form
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JP2023524599A5 (https=
Inventor
ドン，ハンチン
ジェイ． ドゥグッド，ロバート
キース イェーガー，ケイシー
モハン コーシャル，アディティヤ
エリオット ケネディ，サミュエル
アネル ニーサー，ミランダ
マルコ リーヴ，マクスウェル
ピー． レオ，ジョセフ
メヘディ ザーヘディ，ムハンマド
エー． カトゥボイナ，ヴェンカタ
イー．エヌ． アラン，ローラ
ヘルマン チェン，チャンピン
エー． グロッソ，ジョン
サード，ロイヤル ジェイ． ハスケル，ザ
ロイド，リース
リース，ヘイリー
ロバートソン，ジェロド
シウ，ヤピン
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Arvinas Operations Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/2004—Excipients; Inactive ingredients
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Inorganic Chemistry (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2022567864A 2020-05-09 2021-05-06 二官能性化合物を製造する方法、二官能性化合物の超高純度形態、及びそれらを含む剤形 Pending JP2023524599A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063022475P 2020-05-09 2020-05-09
US63/022,475 2020-05-09
US202163149143P 2021-02-12 2021-02-12
US63/149,143 2021-02-12
US202163177378P 2021-04-20 2021-04-20
US63/177,378 2021-04-20
PCT/US2021/031091 WO2021231174A1 (en) 2020-05-09 2021-05-06 Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same

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JP2023524599A true JP2023524599A (ja) 2023-06-12
JP2023524599A5 JP2023524599A5 (https=) 2024-05-10

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US (2) US12043612B2 (https=)
EP (1) EP4146642A1 (https=)
JP (1) JP2023524599A (https=)
KR (1) KR20230015933A (https=)
CN (1) CN115996918A (https=)
AU (1) AU2021273458A1 (https=)
BR (1) BR112022022753A2 (https=)
CA (1) CA3181782A1 (https=)
CL (1) CL2023000074A1 (https=)
CO (1) CO2022017700A2 (https=)
CR (1) CR20220630A (https=)
EC (1) ECSP22086223A (https=)
IL (1) IL297762A (https=)
MX (1) MX2022014071A (https=)
PE (1) PE20231204A1 (https=)
TW (1) TW202208345A (https=)
WO (1) WO2021231174A1 (https=)

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WO2023143427A1 (zh) * 2022-01-27 2023-08-03 杭州领业医药科技有限公司 Arv-110的晶型及其制备方法和用途
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CN118955474A (zh) * 2024-07-29 2024-11-15 浙江爱索拓标记医药科技有限公司 一种放射性同位素碳-14标记的巴德卡鲁胺及其制备方法和应用

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