IL297762A - Methods for producing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms including it - Google Patents
Methods for producing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms including itInfo
- Publication number
- IL297762A IL297762A IL297762A IL29776222A IL297762A IL 297762 A IL297762 A IL 297762A IL 297762 A IL297762 A IL 297762A IL 29776222 A IL29776222 A IL 29776222A IL 297762 A IL297762 A IL 297762A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- impurity
- ultrapure
- tablet
- comprises less
- Prior art date
Links
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- 238000000034 method Methods 0.000 title claims description 172
- 238000004519 manufacturing process Methods 0.000 title claims description 78
- 239000002552 dosage form Substances 0.000 title description 19
- 230000001588 bifunctional effect Effects 0.000 title description 9
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- 239000012535 impurity Substances 0.000 claims description 542
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 194
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 174
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 5
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- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| CN115397821B (zh) | 2019-10-17 | 2024-09-03 | 阿尔维纳斯运营股份有限公司 | 含有与bcl6靶向部分连接的e3泛素连接酶结合部分的双官能分子 |
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| WO2023025268A1 (zh) * | 2021-08-27 | 2023-03-02 | 苏州晶云药物科技股份有限公司 | 哒嗪甲酰胺类化合物的晶型及其制备方法 |
| WO2023143427A1 (zh) * | 2022-01-27 | 2023-08-03 | 杭州领业医药科技有限公司 | Arv-110的晶型及其制备方法和用途 |
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| PE20231204A1 (es) | 2023-08-17 |
| KR20230015933A (ko) | 2023-01-31 |
| JP2023524599A (ja) | 2023-06-12 |
| CN115996918A (zh) | 2023-04-21 |
| CR20220630A (es) | 2023-01-23 |
| AU2021273458A1 (en) | 2022-12-01 |
| CO2022017700A2 (es) | 2022-12-20 |
| CL2023000074A1 (es) | 2023-07-07 |
| MX2022014071A (es) | 2023-01-30 |
| TW202208345A (zh) | 2022-03-01 |
| US20230012321A1 (en) | 2023-01-12 |
| US20240409529A1 (en) | 2024-12-12 |
| US12043612B2 (en) | 2024-07-23 |
| WO2021231174A1 (en) | 2021-11-18 |
| EP4146642A1 (en) | 2023-03-15 |
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