JP2023524207A5 - - Google Patents
Info
- Publication number
- JP2023524207A5 JP2023524207A5 JP2022564532A JP2022564532A JP2023524207A5 JP 2023524207 A5 JP2023524207 A5 JP 2023524207A5 JP 2022564532 A JP2022564532 A JP 2022564532A JP 2022564532 A JP2022564532 A JP 2022564532A JP 2023524207 A5 JP2023524207 A5 JP 2023524207A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- alkyl
- cycloalkyl
- optionally substituted
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2005852.5 | 2020-04-22 | ||
| GBGB2005852.5A GB202005852D0 (en) | 2020-04-22 | 2020-04-22 | Therapeutic compounds |
| PCT/GB2021/050975 WO2021214472A1 (en) | 2020-04-22 | 2021-04-22 | Tetrahydroisoquinoline compounds as nrf2 activators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023524207A JP2023524207A (ja) | 2023-06-09 |
| JP2023524207A5 true JP2023524207A5 (https=) | 2024-04-09 |
| JP7751165B2 JP7751165B2 (ja) | 2025-10-08 |
Family
ID=70859963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022564532A Active JP7751165B2 (ja) | 2020-04-22 | 2021-04-22 | Ｎｒｆ２活性化剤としてのテトラヒドロイソキノリン化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20230159511A1 (https=) |
| EP (1) | EP4139295B1 (https=) |
| JP (1) | JP7751165B2 (https=) |
| KR (1) | KR20230004722A (https=) |
| CN (1) | CN115667242B (https=) |
| AR (1) | AR121913A1 (https=) |
| AU (1) | AU2021258539A1 (https=) |
| BR (1) | BR112022021370A2 (https=) |
| CA (1) | CA3174360A1 (https=) |
| ES (1) | ES3031970T3 (https=) |
| GB (1) | GB202005852D0 (https=) |
| IL (1) | IL297440A (https=) |
| MX (1) | MX2022013396A (https=) |
| PH (1) | PH12022552773A1 (https=) |
| WO (1) | WO2021214472A1 (https=) |
| ZA (1) | ZA202211464B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021004566A (es) | 2018-10-22 | 2021-06-08 | C4X Discovery Ltd | Compuestos terapeuticos. |
| US20240424112A1 (en) | 2021-10-25 | 2024-12-26 | C4X Discovery Limited | Tetrahydroisoquinoline compounds that are keap1 binders. |
| PE20241779A1 (es) * | 2022-01-07 | 2024-09-03 | Chugai Pharmaceutical Co Ltd | Compuesto heterociclico que contiene nitrogeno que tiene un efecto de activacion del nrf2 |
| WO2024130411A1 (en) * | 2022-12-21 | 2024-06-27 | Variational Ai Inc. | Protease inhibitors and methods of using same |
| WO2024262491A1 (ja) * | 2023-06-19 | 2024-12-26 | 中外製薬株式会社 | Ｎｒｆ２活性化作用を有する含窒素複素環化合物の結晶 |
| EP4596534A1 (en) * | 2024-01-31 | 2025-08-06 | University of Copenhagen | Noncovalent small-molecule inhibitors of the keap1-nrf2 interaction |
| WO2025237912A1 (en) | 2024-05-13 | 2025-11-20 | Astrazeneca Ab | Keap1 inhibitors for use in the treatment of bronchiectasis |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140256767A1 (en) * | 2011-10-31 | 2014-09-11 | The Broad Institute, Inc. | Direct inhibitors of keap1-nrf2 interaction as antioxidant inflammation modulators |
| CA2988373A1 (en) * | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
| JP2020097526A (ja) * | 2017-03-28 | 2020-06-25 | 武田薬品工業株式会社 | 複素環化合物 |
| MX2021004566A (es) | 2018-10-22 | 2021-06-08 | C4X Discovery Ltd | Compuestos terapeuticos. |
-
2020
- 2020-04-22 GB GBGB2005852.5A patent/GB202005852D0/en not_active Ceased
-
2021
- 2021-04-22 BR BR112022021370A patent/BR112022021370A2/pt unknown
- 2021-04-22 ES ES21724005T patent/ES3031970T3/es active Active
- 2021-04-22 KR KR1020227040564A patent/KR20230004722A/ko active Pending
- 2021-04-22 US US17/920,244 patent/US20230159511A1/en active Pending
- 2021-04-22 JP JP2022564532A patent/JP7751165B2/ja active Active
- 2021-04-22 MX MX2022013396A patent/MX2022013396A/es unknown
- 2021-04-22 WO PCT/GB2021/050975 patent/WO2021214472A1/en not_active Ceased
- 2021-04-22 AR ARP210101081A patent/AR121913A1/es unknown
- 2021-04-22 PH PH1/2022/552773A patent/PH12022552773A1/en unknown
- 2021-04-22 AU AU2021258539A patent/AU2021258539A1/en active Pending
- 2021-04-22 CA CA3174360A patent/CA3174360A1/en active Pending
- 2021-04-22 CN CN202180030434.4A patent/CN115667242B/zh active Active
- 2021-04-22 IL IL297440A patent/IL297440A/en unknown
- 2021-04-22 EP EP21724005.0A patent/EP4139295B1/en active Active
-
2022
- 2022-10-19 ZA ZA2022/11464A patent/ZA202211464B/en unknown
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