|
EP0368684B2
(en)
|
1988-11-11 |
2004-09-29 |
Medical Research Council |
Cloning immunoglobulin variable domain sequences.
|
|
DK1621554T4
(da)
|
1992-08-21 |
2012-12-17 |
Univ Bruxelles |
Immunoglobuliner blottet for lette kæder
|
|
ES2162863T3
(es)
|
1993-04-29 |
2002-01-16 |
Unilever Nv |
Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae.
|
|
FR2708622B1
(fr)
|
1993-08-02 |
1997-04-18 |
Raymond Hamers |
Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides.
|
|
EP0739981A1
(en)
|
1995-04-25 |
1996-10-30 |
Vrije Universiteit Brussel |
Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
|
|
ES2294799T3
(es)
|
1996-06-27 |
2008-04-01 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. |
Moleculas de anticuerpos que interactuan especificamente con el sitio activo o hendidura de una molecula diana.
|
|
AU3596599A
(en)
|
1998-01-26 |
1999-08-09 |
Unilever Plc |
Method for producing antibody fragments
|
|
EP1141711A1
(en)
|
1999-01-05 |
2001-10-10 |
Unilever Plc |
Binding of antibody fragments to solid supports
|
|
DK1144616T4
(da)
|
1999-01-19 |
2009-03-30 |
Unilever Nv |
Fremgangsmåde til fremstilling af antistoffragmenter
|
|
CA2370351A1
(en)
|
1999-04-22 |
2000-11-02 |
Unilever Plc |
Inhibition of viral infection using monovalent antigen-binding proteins
|
|
US6479280B1
(en)
|
1999-09-24 |
2002-11-12 |
Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw |
Recombinant phages capable of entering host cells via specific interaction with an artificial receptor
|
|
ES2331051T3
(es)
|
1999-11-29 |
2009-12-21 |
Bac Ip B.V. |
Inmovilizacion de moleculas de union de antigenos de un dominio.
|
|
WO2001040310A2
(en)
|
1999-11-29 |
2001-06-07 |
Unilever Plc |
Immobilisation of proteins using a polypeptide segment
|
|
ES2324280T3
(es)
|
2000-03-14 |
2009-08-04 |
Unilever N.V. |
Dominios variables de la cadena pesada de anticuerpos frente a lipasas dieteticas humanas y sus usos.
|
|
US20030190598A1
(en)
|
2000-05-26 |
2003-10-09 |
Jasmid Tanha |
Single-domain antigen-binding antibody fragments derived from llama antibodies
|
|
ATE513854T1
(de)
|
2000-12-13 |
2011-07-15 |
Bac Ip B V |
Proteinraster aus variablen domänen der schweren immunoglobulinkette von kamelen
|
|
US20060073141A1
(en)
|
2001-06-28 |
2006-04-06 |
Domantis Limited |
Compositions and methods for treating inflammatory disorders
|
|
JP4213586B2
(ja)
|
2001-09-13 |
2009-01-21 |
株式会社抗体研究所 |
ラクダ抗体ライブラリーの作製方法
|
|
JP2005289809A
(ja)
|
2001-10-24 |
2005-10-20 |
Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) |
突然変異重鎖抗体
|
|
EP1456410A2
(en)
|
2001-12-11 |
2004-09-15 |
AlgoNomics N.V. |
Method for displaying loops from immunoglobulin domains in different contexts
|
|
EP1456237A2
(en)
|
2001-12-21 |
2004-09-15 |
Vlaams Interuniversitair Instituut voor Biotechnologie vzw. |
Method for cloning of variable domain sequences
|
|
CA2471645A1
(en)
|
2002-01-03 |
2003-07-10 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Immunoconjugates useful for treatment of tumours
|
|
WO2004041863A2
(en)
|
2002-11-08 |
2004-05-21 |
Ablynx N.V. |
Single domain antibodies directed against interferon- gamma and uses therefor
|
|
EP1558645B1
(en)
|
2002-11-08 |
2011-07-27 |
Ablynx N.V. |
Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation
|
|
JP2006517789A
(ja)
|
2003-01-10 |
2006-08-03 |
アブリンクス エン.ヴェー. |
治療用ポリペプチド、その相同物、その断片、および血小板媒介凝集の調節での使用
|
|
US7461263B2
(en)
|
2003-01-23 |
2008-12-02 |
Unspam, Llc. |
Method and apparatus for a non-revealing do-not-contact list system
|
|
EP1656128A4
(en)
|
2003-08-12 |
2007-02-28 |
William M Yarbrough |
SINGLE ACNE TREATMENT AND METHOD OF USE
|
|
ATE485307T1
(de)
|
2003-11-07 |
2010-11-15 |
Ablynx Nv |
Camelidae schwere ketten antikörper vhhs gegen epidermalen wachstumfaktor rezeptor (egfr) und ihre verwendung
|
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
|
WO2006040153A2
(en)
|
2004-10-13 |
2006-04-20 |
Ablynx N.V. |
Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease
|
|
GB0521621D0
(en)
|
2005-10-24 |
2005-11-30 |
Domantis Ltd |
Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases
|
|
MX2007006593A
(es)
|
2004-12-02 |
2008-03-04 |
Domantis Ltd |
Anticuerpos de dominio simple anti-il 1r1 y sus usos terapeuticos.
|
|
AU2005325801A1
(en)
|
2005-01-31 |
2006-08-03 |
Ablynx N.V. |
Method for generating variable domain sequences of heavy chain antibodies
|
|
US8188223B2
(en)
|
2005-05-18 |
2012-05-29 |
Ablynx N.V. |
Serum albumin binding proteins
|
|
ES2694247T3
(es)
|
2005-05-20 |
2018-12-19 |
Ablynx N.V. |
NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación
|
|
EP2441838A3
(en)
|
2006-01-24 |
2013-07-10 |
Domantis Limited |
Fusion proteins that contain natural junctions
|
|
WO2008020079A1
(en)
|
2006-08-18 |
2008-02-21 |
Ablynx N.V. |
Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
|
|
EP2121757A2
(en)
|
2007-02-21 |
2009-11-25 |
Ablynx N.V. |
Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization
|
|
CA2687903C
(en)
|
2007-05-24 |
2016-09-13 |
Ablynx N.V. |
Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders
|
|
WO2016197367A1
(en)
*
|
2015-06-11 |
2016-12-15 |
Wuxi Biologics (Shanghai) Co. Ltd. |
Novel anti-pd-l1 antibodies
|
|
CN106397592A
(zh)
*
|
2015-07-31 |
2017-02-15 |
苏州康宁杰瑞生物科技有限公司 |
针对程序性死亡配体(pd-l1)的单域抗体及其衍生蛋白
|
|
CN107216389B
(zh)
*
|
2016-03-18 |
2022-03-29 |
和迈生物科技有限公司 |
抗pd-l1纳米抗体及其编码序列和用途
|
|
CN107400166A
(zh)
*
|
2016-05-19 |
2017-11-28 |
苏州康宁杰瑞生物科技有限公司 |
针对ctla4的单域抗体及其衍生蛋白
|
|
CN109485726B
(zh)
*
|
2017-09-13 |
2022-07-08 |
和迈生物科技有限公司 |
放射性标记抗纳米抗体在癌症的预后、诊断中的应用
|
|
EP3710480A4
(en)
*
|
2017-11-17 |
2021-12-15 |
Nanjing Legend Biotech Co., Ltd. |
SINGLE-DOMAIN ANTIBODIES AND VARIANTS OF THEM DIRECTED AGAINST PD-L1
|
|
CN110144010B9
(zh)
*
|
2018-02-14 |
2021-01-05 |
上海洛启生物医药技术有限公司 |
阻断型pd-l1驼源单域抗体及其用途
|
|
CN109265548B
(zh)
*
|
2018-09-13 |
2021-05-18 |
东南大学 |
抗pd-l1纳米抗体及其编码序列、制备方法和应用
|
|
CN110627904B
(zh)
*
|
2019-10-31 |
2020-07-10 |
南京蓝盾生物科技有限公司 |
抗人gpc3单克隆抗体
|
|
CN113968903A
(zh)
*
|
2020-07-24 |
2022-01-25 |
迈威(上海)生物科技股份有限公司 |
TGF-β RII突变体及其融合蛋白
|