JP2023522010A - α１－アンチトリプシンの欠損により媒介される呼吸器系疾患の処置のための好中球エラスターゼ阻害剤アルベレスタットに関連する方法 - Google Patents

α１－アンチトリプシンの欠損により媒介される呼吸器系疾患の処置のための好中球エラスターゼ阻害剤アルベレスタットに関連する方法 Download PDF

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JP2023522010A
JP2023522010A JP2022562608A JP2022562608A JP2023522010A JP 2023522010 A JP2023522010 A JP 2023522010A JP 2022562608 A JP2022562608 A JP 2022562608A JP 2022562608 A JP2022562608 A JP 2022562608A JP 2023522010 A JP2023522010 A JP 2023522010A
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methyl
salt
dosage form
alberestat
oxo
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パーキン，ジャクリーン
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メレオ バイオファーマ ４ リミテッド
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Priority claimed from GBGB2005520.8A external-priority patent/GB202005520D0/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2022562608A 2020-04-16 2021-03-16 α１－アンチトリプシンの欠損により媒介される呼吸器系疾患の処置のための好中球エラスターゼ阻害剤アルベレスタットに関連する方法 Pending JP2023522010A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB2005519.0A GB202005519D0 (en) 2020-04-16 2020-04-16 Elastase inhibition
GB2005519.0 2020-04-16
GBGB2005520.8A GB202005520D0 (en) 2020-04-16 2020-04-16 Elastase inhibition
GB2005520.8 2020-04-16
US202062706195P 2020-08-04 2020-08-04
US62/706,195 2020-08-04
PCT/GB2021/050653 WO2021209739A1 (en) 2020-04-16 2021-03-16 Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency

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JP2023522010A true JP2023522010A (ja) 2023-05-26
JP2023522010A5 JP2023522010A5 (https=) 2024-03-19

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EP (2) EP4252850A3 (https=)
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AU (1) AU2021256835A1 (https=)
DK (1) DK4106757T3 (https=)
ES (1) ES2962498T3 (https=)
FI (1) FI4106757T3 (https=)
HR (1) HRP20231065T1 (https=)
HU (1) HUE064089T2 (https=)
IL (1) IL297211B2 (https=)
LT (1) LT4106757T (https=)
MX (1) MX2022012942A (https=)
PL (1) PL4106757T3 (https=)
PT (1) PT4106757T (https=)
SI (1) SI4106757T1 (https=)
WO (2) WO2021209739A1 (https=)

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GB2613460B (en) * 2020-04-20 2025-07-23 Lloyd Hung Loi Tran Pharmaceutical Compositions for use in methods for the prophylaxis or treatment of COVID such as COVID-19; and compound for use in the treatment of a
EP4452303A4 (en) * 2021-12-20 2025-11-12 Tiakis Biotech Ag USE OF ELAFINE IN THE TREATMENT OF COVID-19
CN116407640B (zh) * 2023-03-03 2025-10-31 河南真实生物科技有限公司 包含阿兹夫定和化疗试剂的抗肿瘤药物组合物
WO2025056602A1 (en) * 2023-09-11 2025-03-20 Elastin Biosciences Ltd. Pharmaceutical compositions and use thereof in treatment of conditions and diseases related to elastin deficiency and/or aging
WO2025078838A1 (en) 2023-10-11 2025-04-17 Mereo Biopharma 4 Limited Alvelestat and alpha- 1 antitrypsin for treating respiratory disorders
AU2024406526A1 (en) 2023-12-21 2026-04-16 Mereo Biopharma 4 Limited Use of alvelestat in specific patients
GB202319953D0 (en) 2023-12-22 2024-02-07 Mereo Biopharma 4 Ltd Tablet formulations involving alvelestat
KR20250172196A (ko) * 2024-05-31 2025-12-09 고려대학교 산학협력단 폐 계면활성제 및 항섬유화제를 포함하는 폐섬유증의 예방 또는 치료용 조성물 및 이의 제조방법
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

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JP2007505901A (ja) * 2003-09-18 2007-03-15 アストラゼネカ・アクチエボラーグ 好中球エラスターゼ阻害剤としての２−ピリドン誘導体およびそれらの使用
JP2012518623A (ja) * 2009-02-20 2012-08-16 アストラゼネカ・アクチエボラーグ Ｃｏｐｄの処置に有用な５−ピラゾリル−２−ピリドン誘導体のトシル酸塩

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WO2021209740A1 (en) 2021-10-21
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SI4106757T1 (sl) 2023-11-30
EP4106757B1 (en) 2023-08-23
EP4106757A1 (en) 2022-12-28
HRP20231065T1 (hr) 2023-12-22
US20230190723A1 (en) 2023-06-22
LT4106757T (lt) 2023-11-10
MX2022012942A (es) 2023-01-11
US20230218596A1 (en) 2023-07-13
PT4106757T (pt) 2023-11-17
EP4252850A2 (en) 2023-10-04
IL297211A (en) 2022-12-01
HUE064089T2 (hu) 2024-02-28
ES2962498T3 (es) 2024-03-19
PL4106757T3 (pl) 2024-01-22
WO2021209739A1 (en) 2021-10-21
DK4106757T3 (da) 2023-10-23
AU2021256835A1 (en) 2022-10-13
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