FI4106757T3 - Neutrofiilien elastaasin inhibiittori alvelestaattia sisältäviä menetelmiä alfa-1-antitrypsiinipuutoksen välittämän hengityselintaudin hoitamiseksi - Google Patents

Neutrofiilien elastaasin inhibiittori alvelestaattia sisältäviä menetelmiä alfa-1-antitrypsiinipuutoksen välittämän hengityselintaudin hoitamiseksi Download PDF

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Publication number
FI4106757T3
FI4106757T3 FIEP21714345.2T FI21714345T FI4106757T3 FI 4106757 T3 FI4106757 T3 FI 4106757T3 FI 21714345 T FI21714345 T FI 21714345T FI 4106757 T3 FI4106757 T3 FI 4106757T3
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Finland
Prior art keywords
salt
alvelestat
disease
dose
alvestat
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FIEP21714345.2T
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English (en)
Finnish (fi)
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Jacqueline Parkin
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Mereo Biopharma 4 Ltd
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Priority claimed from GBGB2005519.0A external-priority patent/GB202005519D0/en
Priority claimed from GBGB2005520.8A external-priority patent/GB202005520D0/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
FIEP21714345.2T 2020-04-16 2021-03-16 Neutrofiilien elastaasin inhibiittori alvelestaattia sisältäviä menetelmiä alfa-1-antitrypsiinipuutoksen välittämän hengityselintaudin hoitamiseksi FI4106757T3 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB2005519.0A GB202005519D0 (en) 2020-04-16 2020-04-16 Elastase inhibition
GBGB2005520.8A GB202005520D0 (en) 2020-04-16 2020-04-16 Elastase inhibition
US202062706195P 2020-08-04 2020-08-04
PCT/GB2021/050653 WO2021209739A1 (en) 2020-04-16 2021-03-16 Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency

Publications (1)

Publication Number Publication Date
FI4106757T3 true FI4106757T3 (fi) 2023-10-23

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ID=78083570

Family Applications (1)

Application Number Title Priority Date Filing Date
FIEP21714345.2T FI4106757T3 (fi) 2020-04-16 2021-03-16 Neutrofiilien elastaasin inhibiittori alvelestaattia sisältäviä menetelmiä alfa-1-antitrypsiinipuutoksen välittämän hengityselintaudin hoitamiseksi

Country Status (16)

Country Link
US (2) US20230218596A1 (https=)
EP (2) EP4252850A3 (https=)
JP (1) JP2023522010A (https=)
AU (1) AU2021256835A1 (https=)
DK (1) DK4106757T3 (https=)
ES (1) ES2962498T3 (https=)
FI (1) FI4106757T3 (https=)
HR (1) HRP20231065T1 (https=)
HU (1) HUE064089T2 (https=)
IL (1) IL297211B2 (https=)
LT (1) LT4106757T (https=)
MX (1) MX2022012942A (https=)
PL (1) PL4106757T3 (https=)
PT (1) PT4106757T (https=)
SI (1) SI4106757T1 (https=)
WO (2) WO2021209739A1 (https=)

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CN116407640B (zh) * 2023-03-03 2025-10-31 河南真实生物科技有限公司 包含阿兹夫定和化疗试剂的抗肿瘤药物组合物
WO2025056602A1 (en) * 2023-09-11 2025-03-20 Elastin Biosciences Ltd. Pharmaceutical compositions and use thereof in treatment of conditions and diseases related to elastin deficiency and/or aging
WO2025078838A1 (en) 2023-10-11 2025-04-17 Mereo Biopharma 4 Limited Alvelestat and alpha- 1 antitrypsin for treating respiratory disorders
AU2024406526A1 (en) 2023-12-21 2026-04-16 Mereo Biopharma 4 Limited Use of alvelestat in specific patients
GB202319953D0 (en) 2023-12-22 2024-02-07 Mereo Biopharma 4 Ltd Tablet formulations involving alvelestat
KR20250172196A (ko) * 2024-05-31 2025-12-09 고려대학교 산학협력단 폐 계면활성제 및 항섬유화제를 포함하는 폐섬유증의 예방 또는 치료용 조성물 및 이의 제조방법
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EP4252850A3 (en) 2023-11-15
WO2021209740A1 (en) 2021-10-21
IL297211B1 (en) 2025-08-01
SI4106757T1 (sl) 2023-11-30
EP4106757B1 (en) 2023-08-23
EP4106757A1 (en) 2022-12-28
HRP20231065T1 (hr) 2023-12-22
US20230190723A1 (en) 2023-06-22
LT4106757T (lt) 2023-11-10
MX2022012942A (es) 2023-01-11
US20230218596A1 (en) 2023-07-13
PT4106757T (pt) 2023-11-17
EP4252850A2 (en) 2023-10-04
IL297211A (en) 2022-12-01
HUE064089T2 (hu) 2024-02-28
JP2023522010A (ja) 2023-05-26
ES2962498T3 (es) 2024-03-19
PL4106757T3 (pl) 2024-01-22
WO2021209739A1 (en) 2021-10-21
DK4106757T3 (da) 2023-10-23
AU2021256835A1 (en) 2022-10-13
IL297211B2 (en) 2025-12-01

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