JP2023519304A - 多発性骨髄腫における免疫療法の標的およびその同定方法 - Google Patents

多発性骨髄腫における免疫療法の標的およびその同定方法 Download PDF

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JP2023519304A
JP2023519304A JP2022558042A JP2022558042A JP2023519304A JP 2023519304 A JP2023519304 A JP 2023519304A JP 2022558042 A JP2022558042 A JP 2022558042A JP 2022558042 A JP2022558042 A JP 2022558042A JP 2023519304 A JP2023519304 A JP 2023519304A
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ペルナ,ファビアナ
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ザ・トラスティーズ・オブ・インディアナ・ユニバーシティー
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JP2022558042A 2020-03-27 2021-03-26 多発性骨髄腫における免疫療法の標的およびその同定方法 Pending JP2023519304A (ja)

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US202063000694P 2020-03-27 2020-03-27
US63/000,694 2020-03-27
PCT/US2021/024431 WO2021195536A1 (en) 2020-03-27 2021-03-26 Immunotherapeutic targets in multiple myeloma and methods for their identification

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US (1) US20230137672A1 (https=)
EP (1) EP4126243A4 (https=)
JP (1) JP2023519304A (https=)
KR (1) KR20220160053A (https=)
CN (1) CN116097096A (https=)
CA (1) CA3175860A1 (https=)
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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12122839B2 (en) 2020-08-05 2024-10-22 Synthekine, Inc. IFNGR binding synthetic cytokines and methods of use
WO2022031890A1 (en) 2020-08-05 2022-02-10 Synthekine, Inc. Ifngr2 binding molecules and methods of use
US20230365696A1 (en) * 2020-08-05 2023-11-16 Synthekine, Inc. Ifngr1 binding molecules and methods of use
CN114031690B (zh) * 2021-12-03 2022-07-15 广州百暨基因科技有限公司 靶向ccr1和nkg2d配体的嵌合抗原受体及其应用
GB202117928D0 (en) 2021-12-11 2022-01-26 Cancer Research Tech Ltd Immunotherapy for cancer
CN116712550A (zh) * 2023-07-11 2023-09-08 中国医学科学院血液病医院(中国医学科学院血液学研究所) 治疗高增殖活性和多药耐药的多发性骨髓瘤的组合物及其应用
CN118501473A (zh) * 2024-05-22 2024-08-16 中国人民解放军海军军医大学第二附属医院 一种IgD型多发性骨髓瘤筛查试剂盒及其筛查系统
CN118878662A (zh) * 2024-09-03 2024-11-01 北京大学第六医院 多肽及其应用、试剂盒及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170074883A1 (en) * 2015-09-14 2017-03-16 Leukemia Therapeutics, LLC Identification of novel diagnostics and therapeutics by modulating rhoh
JP2018520653A (ja) * 2015-06-25 2018-08-02 イマティクス バイオテクノロジーズ ゲーエムベーハー 骨髄腫およびその他のがんの免疫療法において使用するための新規細胞エピトープおよび細胞エピトープ組み合わせ
JP2019530456A (ja) * 2016-09-28 2019-10-24 ガビッシュ−ガリラヤ バイオ アプリケーションズ リミテッド 癌の新規抗原性シグネチャーを標的としたcar療法のためのユニバーサルプラットフォーム

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6046012A (en) * 1993-07-19 2000-04-04 Hoffmann-La Roche Inc. Antibody to IL-12 receptor
US20030092002A1 (en) * 1997-09-17 2003-05-15 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU2048901A (en) * 1999-11-29 2001-06-04 Trustees Of Columbia University In The City Of New York, The Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/melanoma
US8679771B2 (en) * 2007-01-25 2014-03-25 The Regents Of The University Of California Specific N-terminal labeling of peptides and proteins in complex mixtures
WO2012022634A1 (en) * 2010-08-16 2012-02-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Classification, diagnosis and prognosis of multiple myeloma
GB2495113A (en) * 2011-09-29 2013-04-03 Bioinvent Int Ab Anti-ICAM-1 antibody for treating multiple-myeloma-related disorders
WO2014082083A1 (en) * 2012-11-26 2014-05-30 Caris Science, Inc. Biomarker compositions and methods
WO2015121454A1 (en) * 2014-02-14 2015-08-20 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
SI3331910T1 (sl) * 2015-08-03 2020-07-31 Engmab Sarl Monoklonska protitelesa proti humani antigen dozorevanja limfocitov B (BCMA)
US20170234874A1 (en) * 2015-10-07 2017-08-17 Clearbridge Biophotonics Pte Ltd. Integrated visual morphology and cell protein expression using resonance-light scattering
FR3051555B1 (fr) * 2016-05-20 2018-05-11 Horiba Abx Sas Detection de la maladie residuelle du myelome multiple
WO2018027197A1 (en) * 2016-08-04 2018-02-08 Memorial Sloan-Kettering Cancer Center Cancer antigen targets and uses thereof
LT3535392T (lt) * 2016-11-02 2024-04-25 Universität Basel Imunologiškai atpažįstami ląstelių paviršiaus variantai, skirti naudoti ląstelių terapijoje
WO2019094360A1 (en) * 2017-11-07 2019-05-16 The Board Of Regents Of The University Of Texas System Targeting lilrb4 with car-t or car-nk cells in the treatment of cancer
KR20250070609A (ko) * 2017-11-14 2025-05-20 아르셀엑스, 인크. 다기능성 면역 세포 요법
AU2018370217A1 (en) * 2017-11-17 2020-05-28 Memorial Sloan-Kettering Cancer Center Methods and compositions for alleviating Cytokine Release Syndrome
EA202091540A1 (ru) * 2017-12-22 2021-03-22 Джаунс Терапьютикс, Инк. Антитела к lilrb2
WO2020033585A1 (en) * 2018-08-07 2020-02-13 The Broad Institute, Inc. Methods for combinatorial screening and use of therapeutic targets thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018520653A (ja) * 2015-06-25 2018-08-02 イマティクス バイオテクノロジーズ ゲーエムベーハー 骨髄腫およびその他のがんの免疫療法において使用するための新規細胞エピトープおよび細胞エピトープ組み合わせ
US20170074883A1 (en) * 2015-09-14 2017-03-16 Leukemia Therapeutics, LLC Identification of novel diagnostics and therapeutics by modulating rhoh
JP2019530456A (ja) * 2016-09-28 2019-10-24 ガビッシュ−ガリラヤ バイオ アプリケーションズ リミテッド 癌の新規抗原性シグネチャーを標的としたcar療法のためのユニバーサルプラットフォーム

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KR20220160053A (ko) 2022-12-05
CA3175860A1 (en) 2021-09-30
IL296714A (en) 2022-11-01
CN116097096A (zh) 2023-05-09
WO2021195536A1 (en) 2021-09-30
US20230137672A1 (en) 2023-05-04
EP4126243A4 (en) 2024-06-12
EP4126243A1 (en) 2023-02-08

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