JP2023518973A5 - - Google Patents
Info
- Publication number
- JP2023518973A5 JP2023518973A5 JP2022558084A JP2022558084A JP2023518973A5 JP 2023518973 A5 JP2023518973 A5 JP 2023518973A5 JP 2022558084 A JP2022558084 A JP 2022558084A JP 2022558084 A JP2022558084 A JP 2022558084A JP 2023518973 A5 JP2023518973 A5 JP 2023518973A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- salt
- oligopeptide
- substituted
- acceptable acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063000364P | 2020-03-26 | 2020-03-26 | |
| US63/000,364 | 2020-03-26 | ||
| PCT/US2021/024142 WO2021195372A1 (en) | 2020-03-26 | 2021-03-25 | Lipophilic enantiomers of desacetylglucosamine muramyl dipeptide with anti-inflammatory and growth promoting activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023518973A JP2023518973A (ja) | 2023-05-09 |
| JP2023518973A5 true JP2023518973A5 (enExample) | 2025-02-07 |
| JP7667177B2 JP7667177B2 (ja) | 2025-04-22 |
Family
ID=77892334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022558084A Active JP7667177B2 (ja) | 2020-03-26 | 2021-03-25 | 抗炎症性および成長促進活性を有するデスアセチルグルコサミンムラミルジペプチドの親油性エナンチオマー |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12492222B2 (enExample) |
| EP (1) | EP4126040B1 (enExample) |
| JP (1) | JP7667177B2 (enExample) |
| KR (1) | KR102897673B1 (enExample) |
| CN (1) | CN115605226A (enExample) |
| AU (1) | AU2021241625B2 (enExample) |
| BR (1) | BR112022019202A2 (enExample) |
| CA (1) | CA3172936A1 (enExample) |
| ES (1) | ES3014076T3 (enExample) |
| MX (1) | MX2022011751A (enExample) |
| PL (1) | PL4126040T3 (enExample) |
| WO (1) | WO2021195372A1 (enExample) |
| ZA (1) | ZA202210586B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3929293A3 (en) | 2015-04-03 | 2022-03-16 | University Of Massachusetts | Fully stabilized asymmetric sirna |
| WO2017030973A1 (en) | 2015-08-14 | 2017-02-23 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| WO2017132669A1 (en) | 2016-01-31 | 2017-08-03 | University Of Massachusetts | Branched oligonucleotides |
| WO2018237245A1 (en) | 2017-06-23 | 2018-12-27 | University Of Massachusetts | TWO TAIL SELF-ADMINISTRATION SIRNA AND ASSOCIATED METHODS |
| BR112021002440A2 (pt) | 2018-08-10 | 2021-05-04 | University Of Massachusetts | oligonucleotídeos modificados visando snps |
| WO2020041769A1 (en) | 2018-08-23 | 2020-02-27 | University Of Massachusetts | O-methyl rich fully stabilized oligonucleotides |
| CN113614232A (zh) | 2019-01-18 | 2021-11-05 | 马萨诸塞大学 | 动态药代动力学修饰锚 |
| EP3946369A4 (en) | 2019-03-26 | 2023-10-18 | University Of Massachusetts | MODIFIED OLIGONUCLEOTIDES WITH INCREASED STABILITY |
| KR20220047989A (ko) | 2019-08-09 | 2022-04-19 | 유니버시티 오브 매사추세츠 | Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드 |
| US12365894B2 (en) | 2019-09-16 | 2025-07-22 | University Of Massachusetts | Branched lipid conjugates of siRNA for specific tissue delivery |
| AU2021244600A1 (en) | 2020-03-26 | 2022-11-03 | University Of Massachusetts | Synthesis of modified oligonucleotides with increased stability |
| CN115605226A (zh) | 2020-03-26 | 2023-01-13 | 纽特莱特公司（Us） | 具有抗炎和生长促进活性的去乙酰基葡糖胺胞壁酰二肽的亲脂对映异构体 |
| CA3174079A1 (en) | 2020-05-26 | 2021-12-02 | Anastasia Khvorova | Synthetic oligonucleotides having regions of block and cluster modifications |
| WO2024102639A1 (en) * | 2022-11-08 | 2024-05-16 | The Scripps Research Institute | N-arylpyrazole nod2 agonists as promoters of immune checkpoint inhibitor therapy |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2428051A1 (fr) * | 1978-06-05 | 1980-01-04 | Anvar | Nouveaux composes du type muramyl-peptide et medicaments les contenant |
| SI9011830B (sl) | 1990-09-27 | 1999-12-31 | Univerza V Ljubljani, Fakulteta Za Farmacijo | Novi N-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo |
| JPH0655107B2 (ja) | 1991-03-13 | 1994-07-27 | 全国農業協同組合連合会 | 家畜，家禽，および魚介類用の抗仮性狂犬病ならびに抗病性飼料および飼料用添加物 |
| WO1993013791A1 (en) | 1992-01-20 | 1993-07-22 | Peptech (Uk) Limited | Use of muramyl peptides for enhancing animal production |
| MX9301789A (es) | 1992-04-03 | 1993-10-01 | Iaf Biochem Int | Nuevos oligopeptidos lipofilicos con actividad inmunomoduladora. |
| CN1162920A (zh) * | 1994-09-21 | 1997-10-22 | 英国佩普技术有限公司 | 胞壁酰肽化合物的应用 |
| US5976580A (en) | 1995-06-07 | 1999-11-02 | Novus International, Inc. | Nutrient formulation and process for enhancing the health, livability, cumulative weight gain or feed efficiency in poultry and other animals |
| GB9618673D0 (en) * | 1996-09-06 | 1996-10-16 | Peptech Uk Ltd | The use of muramyl peptides |
| RU2375047C2 (ru) | 2004-03-26 | 2009-12-10 | Лек Фармасьютиклз Д.Д. | Фармацевтическая лекарственная форма, устойчивая к действию желудочного сока, включающая n-(2-(2-фталимидоэтокси)ацетил)-l-аланил-d-глутаминовую кислоту (lk 423) |
| CA2666814A1 (en) | 2006-08-21 | 2008-05-29 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| WO2008070564A1 (en) | 2006-12-01 | 2008-06-12 | The Government Of The U.S.A, As Represented By The Secretary, Departmentof Health And Human Services | Uses of muramyl dipeptide (mdp) for treating inflammation |
| KR20100059863A (ko) | 2007-09-11 | 2010-06-04 | 몬도바이오테크 래보래토리즈 아게 | 치료제로서의 펩티드 티모신 베타 ４ 단독 또는 세크로핀 ａ와의 배합물의 용도 |
| CN101918001B (zh) | 2007-12-06 | 2016-11-16 | 英特威国际有限公司 | 使用醋酸美仑孕酮和齐帕特罗或其盐的联合治疗 |
| CN101756026A (zh) | 2008-12-11 | 2010-06-30 | 天津瑞贝特科技发展有限公司 | 增强虾、蟹硬壳速度的营养组合物及其制备方法、应用 |
| DE102009002044A1 (de) | 2009-03-31 | 2010-10-07 | Evonik Degussa Gmbh | Dipeptide als Futtermitteladditive |
| BR112013027845A2 (pt) | 2011-05-18 | 2017-01-03 | Ajinomoto Kk | Imunoestimulante, ração, método para produzir um imunoestimulante, e, método para imunoestimulação |
| CN102578414B (zh) | 2012-02-23 | 2014-01-01 | 青岛绿曼生物工程有限公司 | 促进猪生长育肥、提高免疫力的复方蜂胶饲料添加剂及其制备方法 |
| WO2013172517A1 (ko) | 2012-05-16 | 2013-11-21 | 서울대학교산학협력단 | 뮤라밀-다이펩타이드를 포함하는 골소실 예방, 골재생 또는 골형성 촉진용 약학 조성물 |
| EP2975046A1 (en) * | 2014-07-16 | 2016-01-20 | The Provost, Fellows, Foundation Scholars, and The Other Members of Board, of The College of The Holy and Undivided Trinity of Queen Elizabeth | Novel compounds |
| WO2017068149A1 (en) | 2015-10-21 | 2017-04-27 | Cysal Gmbh | Aspartyl-dipeptides for aquaculture |
| EP3387005B1 (en) * | 2015-12-10 | 2022-08-24 | Bharat Biotech International Limited | Novel muramyl peptide derivative compound, synthesis and uses thereof |
| CN109562158A (zh) | 2016-06-23 | 2019-04-02 | 纽特莱特公司 | 在动物中促进生长和提高饲料转化率的方法 |
| TWI634902B (zh) * | 2017-10-28 | 2018-09-11 | 醫療財團法人徐元智先生醫藥基金會亞東紀念醫院 | Use of glucosamine peptide compounds for the treatment of abnormal liver metabolism |
| WO2020019128A1 (zh) | 2018-07-23 | 2020-01-30 | 深圳市健元医药科技有限公司 | 丙氨酸—赖氨酸—谷氨酸三肽衍生物及其应用 |
| CN115605226A (zh) | 2020-03-26 | 2023-01-13 | 纽特莱特公司（Us） | 具有抗炎和生长促进活性的去乙酰基葡糖胺胞壁酰二肽的亲脂对映异构体 |
-
2021
- 2021-03-25 CN CN202180038086.5A patent/CN115605226A/zh active Pending
- 2021-03-25 MX MX2022011751A patent/MX2022011751A/es unknown
- 2021-03-25 ES ES21774898T patent/ES3014076T3/es active Active
- 2021-03-25 KR KR1020227036717A patent/KR102897673B1/ko active Active
- 2021-03-25 BR BR112022019202A patent/BR112022019202A2/pt unknown
- 2021-03-25 JP JP2022558084A patent/JP7667177B2/ja active Active
- 2021-03-25 WO PCT/US2021/024142 patent/WO2021195372A1/en not_active Ceased
- 2021-03-25 PL PL21774898.7T patent/PL4126040T3/pl unknown
- 2021-03-25 EP EP21774898.7A patent/EP4126040B1/en active Active
- 2021-03-25 US US17/912,647 patent/US12492222B2/en active Active
- 2021-03-25 AU AU2021241625A patent/AU2021241625B2/en active Active
- 2021-03-25 CA CA3172936A patent/CA3172936A1/en active Pending
-
2022
- 2022-09-23 ZA ZA2022/10586A patent/ZA202210586B/en unknown
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