SI9011830B - Novi N-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo - Google Patents

Novi N-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo Download PDF

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Publication number
SI9011830B
SI9011830B SI9011830A SI9011830A SI9011830B SI 9011830 B SI9011830 B SI 9011830B SI 9011830 A SI9011830 A SI 9011830A SI 9011830 A SI9011830 A SI 9011830A SI 9011830 B SI9011830 B SI 9011830B
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SI
Slovenia
Prior art keywords
chem
hydrogen
carbon atoms
group
straight
Prior art date
Application number
SI9011830A
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English (en)
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SI9011830A (en
Inventor
Slavko Pe�ar
Marija Sollner
Uro� Urleb
Danijel Kikelj
Ga�per Marc
Ale� Krbav�i�
Vlado Kotnik
Branka Wraber-Herzog
Sa�a Sim�i�
Alojz Ihan
Lidija Klamfer
Lu�ka Pov�i�
Zdravko Kopitar
Anton �talc
Original Assignee
Univerza V Ljubljani, Fakulteta Za Farmacijo
Lek,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univerza V Ljubljani, Fakulteta Za Farmacijo, Lek, filed Critical Univerza V Ljubljani, Fakulteta Za Farmacijo
Publication of SI9011830A publication Critical patent/SI9011830A/sl
Publication of SI9011830B publication Critical patent/SI9011830B/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/823—Immunogenic carrier or carrier per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/826—Additives, e.g. buffers, diluents, preservatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Claims (2)

  1. p\pr:24190o99 1 PATENTNA ZAHTEVKA 1. N-acildipeptidi s formulo I (s,r) (R) R—CO-NH-CH—CONH—CH—R3 i I I Ri R2 v kateri R predstavlja (s,R) —CH-(CHa)b.-Y-(C3|i).-2 R4 kjer je R4 vodik, Y je -CH2-, -0-, -C0-, -C00-, -0C0-, -CONH-, m je celo Število od 1 do 4, nje celo število od 1 do 6, Z je vodik, -NH-X-RS, kjer je X -C0-, R5 je nerazvejen alkil s C2-io ogljikovimi atomi, adamantil, ciklopentil, cikloheksil, cikloheptil ali ciklooktil, ali je Z ciklični imid s formulama p\pr:24190o99 2
    ©Λ ^11 Ri predstavlja vodik, nera2vejen ali razvejen alkil z 2 do 10 ogljikovimi atomi, hidroksimetil ali alkoksimetil, R2 predstavlja skupino -CO-A-, kjer je A skupina -0-¾ ali -NH-R7, kjer je R^ vodik, nerazvejen ali razvejen alkil z 1 do 10 ogljikovimi atomi ali benzil, R7 je vodik ali raven ali razvejen alkil z 1 do 10 ogljikovimi atomi, R3 predstavlja skupino -(CH2)p-CO-W, kjer je P 2 W je skupina -0-R8 ali NH-R9, kjer je Rg vodik ali nerazvejen ali razvejen alkil z 1 do 10 ogljikovimi atomi, p\pr:24190o99 3 R9 je vodik, nerazvejen ali razvejen alkil z 1 do 10 ogljikovimi atomi, adamantil, ciklopentil, cikloheksil, cikloheptil ali ciklooktil, ali njihove farmacevtsko sprejemljive soli z imunomodulatomim in antitumomim delovanjem.
  2. 2. Farmacevtski sestavki, označeni s tem, da vsebujejo kot aktivno sestavino terapevtsko učinkovito količino N-acildipeptida s formulo I po zahtevku 1 skupaj s farmacevtsko sprejemljivimi nosilci. Za Univerza v Ljubljani, Fakulteta za farmacijo LEK, tovarna farmacevtskih in kemičnih izdelkov, d. d.: PATENTNA PISARNA, LJUBLJANA, ČOPOVA 14
SI9011830A 1990-09-27 1990-09-27 Novi N-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo SI9011830B (sl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU183090A YU183090A (sh) 1990-09-27 1990-09-27 Novi n-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, kojih vsebujejo

Publications (2)

Publication Number Publication Date
SI9011830A SI9011830A (en) 1997-10-31
SI9011830B true SI9011830B (sl) 1999-12-31

Family

ID=25555754

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9011830A SI9011830B (sl) 1990-09-27 1990-09-27 Novi N-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo

Country Status (7)

Country Link
US (1) US5514654A (sl)
EP (1) EP0477912B1 (sl)
JP (1) JP2795421B2 (sl)
AT (1) ATE204880T1 (sl)
DE (1) DE69132707T2 (sl)
SI (1) SI9011830B (sl)
YU (1) YU183090A (sl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9301789A (es) * 1992-04-03 1993-10-01 Iaf Biochem Int Nuevos oligopeptidos lipofilicos con actividad inmunomoduladora.
SI9300212A (en) * 1993-04-22 1994-12-31 Univ Ljubljani Novel N-acyldipeptides, process for the preparation thereof and pharmaceutical composition containing the same
SG91244A1 (en) * 1996-06-24 2002-09-17 Givaudan Roure Int Malodour preventing agents
AUPO161196A0 (en) * 1996-08-13 1996-09-05 Commonwealth Scientific And Industrial Research Organisation Novel compounds
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
AU1180200A (en) * 1999-11-12 2001-05-30 Fujimoto Brothers Co., Ltd. Antiinflammatory medicinal compositions
AU2005226927B2 (en) * 2004-03-26 2010-09-23 Lek Pharmaceuticals D.D. Gastroresistant pharmaceutical dosage form comprising N-(2-(2-phthalimidoethoxy)-acetyl)-L-alanyl-D-glutamic acid (LK-423)
US20080124279A1 (en) * 2006-11-17 2008-05-29 Antoine Andremont Colonic delivery using Zn/pectin beads with a Eudragit coating
CN103313968A (zh) 2010-11-15 2013-09-18 Abbvie公司 Nampt和rock抑制剂
CN109562158A (zh) 2016-06-23 2019-04-02 纽特莱特公司 在动物中促进生长和提高饲料转化率的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2460288A1 (fr) * 1979-06-29 1981-01-23 Rhone Poulenc Ind Nouveaux dipeptides, leur preparation et les medicaments qui les contiennent

Also Published As

Publication number Publication date
YU183090A (sh) 1992-12-21
EP0477912A3 (en) 1992-08-12
SI9011830A (en) 1997-10-31
EP0477912B1 (en) 2001-08-29
DE69132707T2 (de) 2002-06-20
ATE204880T1 (de) 2001-09-15
JP2795421B2 (ja) 1998-09-10
US5514654A (en) 1996-05-07
DE69132707D1 (de) 2001-10-04
EP0477912A2 (en) 1992-04-01
JPH06220087A (ja) 1994-08-09

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