PL4126040T3 - Lipofilowe enancjomery deacetyloglukozamino–muramylodipeptydu o aktywności przeciwzapalnej i wspomagającej wzrost - Google Patents
Lipofilowe enancjomery deacetyloglukozamino–muramylodipeptydu o aktywności przeciwzapalnej i wspomagającej wzrostInfo
- Publication number
- PL4126040T3 PL4126040T3 PL21774898.7T PL21774898T PL4126040T3 PL 4126040 T3 PL4126040 T3 PL 4126040T3 PL 21774898 T PL21774898 T PL 21774898T PL 4126040 T3 PL4126040 T3 PL 4126040T3
- Authority
- PL
- Poland
- Prior art keywords
- desacetylglucosamine
- lipophilic
- enantiomers
- inflammatory
- growth promoting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/5555—Muramyl dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
- Peptides Or Proteins (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063000364P | 2020-03-26 | 2020-03-26 | |
| PCT/US2021/024142 WO2021195372A1 (en) | 2020-03-26 | 2021-03-25 | Lipophilic enantiomers of desacetylglucosamine muramyl dipeptide with anti-inflammatory and growth promoting activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL4126040T3 true PL4126040T3 (pl) | 2025-04-28 |
Family
ID=77892334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL21774898.7T PL4126040T3 (pl) | 2020-03-26 | 2021-03-25 | Lipofilowe enancjomery deacetyloglukozamino–muramylodipeptydu o aktywności przeciwzapalnej i wspomagającej wzrost |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12492222B2 (pl) |
| EP (1) | EP4126040B1 (pl) |
| JP (1) | JP7667177B2 (pl) |
| KR (1) | KR102897673B1 (pl) |
| CN (1) | CN115605226A (pl) |
| AU (1) | AU2021241625B2 (pl) |
| BR (1) | BR112022019202A2 (pl) |
| CA (1) | CA3172936A1 (pl) |
| ES (1) | ES3014076T3 (pl) |
| MX (1) | MX2022011751A (pl) |
| PL (1) | PL4126040T3 (pl) |
| WO (1) | WO2021195372A1 (pl) |
| ZA (1) | ZA202210586B (pl) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016161388A1 (en) | 2015-04-03 | 2016-10-06 | University Of Massachusetts | Fully stabilized asymmetric sirna |
| WO2017030973A1 (en) | 2015-08-14 | 2017-02-23 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| US10478503B2 (en) | 2016-01-31 | 2019-11-19 | University Of Massachusetts | Branched oligonucleotides |
| CA3064590A1 (en) | 2017-06-23 | 2018-12-27 | University Of Massachusetts | Two-tailed self-delivering sirna and related methods |
| JP7627042B2 (ja) | 2018-08-23 | 2025-02-05 | ユニバーシティー オブ マサチューセッツ | Ｏ－メチルリッチ完全安定化オリゴヌクレオチド |
| WO2020150636A1 (en) | 2019-01-18 | 2020-07-23 | University Of Massachusetts | Dynamic pharmacokinetic-modifying anchors |
| US11820985B2 (en) | 2019-03-26 | 2023-11-21 | University Of Massachusetts | Modified oligonucleotides with increased stability |
| CA3149835A1 (en) | 2019-08-09 | 2021-02-18 | University Of Massachusetts | Chemically modified oligonucleotides targeting snps |
| US12365894B2 (en) | 2019-09-16 | 2025-07-22 | University Of Massachusetts | Branched lipid conjugates of siRNA for specific tissue delivery |
| US12146136B2 (en) | 2020-03-26 | 2024-11-19 | University Of Massachusetts | Synthesis of modified oligonucleotides with increased stability |
| PL4126040T3 (pl) | 2020-03-26 | 2025-04-28 | Nutrivert Inc. | Lipofilowe enancjomery deacetyloglukozamino–muramylodipeptydu o aktywności przeciwzapalnej i wspomagającej wzrost |
| EP4157289A4 (en) | 2020-05-26 | 2024-06-26 | University Of Massachusetts | Synthetic oligonucleotides having regions of block and cluster modifications |
| WO2024102639A1 (en) * | 2022-11-08 | 2024-05-16 | The Scripps Research Institute | N-arylpyrazole nod2 agonists as promoters of immune checkpoint inhibitor therapy |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2428051A1 (fr) * | 1978-06-05 | 1980-01-04 | Anvar | Nouveaux composes du type muramyl-peptide et medicaments les contenant |
| SI9011830B (sl) | 1990-09-27 | 1999-12-31 | Univerza V Ljubljani, Fakulteta Za Farmacijo | Novi N-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo |
| JPH0655107B2 (ja) | 1991-03-13 | 1994-07-27 | 全国農業協同組合連合会 | 家畜，家禽，および魚介類用の抗仮性狂犬病ならびに抗病性飼料および飼料用添加物 |
| WO1993013791A1 (en) | 1992-01-20 | 1993-07-22 | Peptech (Uk) Limited | Use of muramyl peptides for enhancing animal production |
| MX9301789A (es) * | 1992-04-03 | 1993-10-01 | Iaf Biochem Int | Nuevos oligopeptidos lipofilicos con actividad inmunomoduladora. |
| CN1162920A (zh) * | 1994-09-21 | 1997-10-22 | 英国佩普技术有限公司 | 胞壁酰肽化合物的应用 |
| US5976580A (en) | 1995-06-07 | 1999-11-02 | Novus International, Inc. | Nutrient formulation and process for enhancing the health, livability, cumulative weight gain or feed efficiency in poultry and other animals |
| GB9618673D0 (en) * | 1996-09-06 | 1996-10-16 | Peptech Uk Ltd | The use of muramyl peptides |
| US20100183714A1 (en) | 2004-03-26 | 2010-07-22 | Lek Pharmaceuticals D.D. | Gastroresistant pharmaceutical dosage form comprising n-(2-(2- phthalimidoethoxy)-acetyl)-l-alanyl-d-glutamic acid (lk-423) |
| JP2010510171A (ja) | 2006-08-21 | 2010-04-02 | ユナイテッド セラピューティクス コーポレーション | ウイルス感染症の治療のための併用療法 |
| US8603978B2 (en) | 2006-12-01 | 2013-12-10 | The United States of America, as represented by the Secretary, Department of Health and Humand Services | Use of muramyl dipeptide (MDP) for treating inflammation |
| US20100184698A1 (en) | 2007-09-11 | 2010-07-22 | Dorian Bevec | Use of a deslorelin and mastoparan as a therapeutic agent |
| US8580772B2 (en) | 2007-12-06 | 2013-11-12 | Intervet Inc. | Combination therapies using melengestrol acetate and zilpaterol or its salts |
| CN101756026A (zh) | 2008-12-11 | 2010-06-30 | 天津瑞贝特科技发展有限公司 | 增强虾、蟹硬壳速度的营养组合物及其制备方法、应用 |
| DE102009002044A1 (de) | 2009-03-31 | 2010-10-07 | Evonik Degussa Gmbh | Dipeptide als Futtermitteladditive |
| JPWO2012157699A1 (ja) | 2011-05-18 | 2014-07-31 | 味の素株式会社 | 動物用免疫賦活剤、それを含む飼料及びその製造方法 |
| CN102578414B (zh) | 2012-02-23 | 2014-01-01 | 青岛绿曼生物工程有限公司 | 促进猪生长育肥、提高免疫力的复方蜂胶饲料添加剂及其制备方法 |
| WO2013172517A1 (ko) | 2012-05-16 | 2013-11-21 | 서울대학교산학협력단 | 뮤라밀-다이펩타이드를 포함하는 골소실 예방, 골재생 또는 골형성 촉진용 약학 조성물 |
| EP2975046A1 (en) * | 2014-07-16 | 2016-01-20 | The Provost, Fellows, Foundation Scholars, and The Other Members of Board, of The College of The Holy and Undivided Trinity of Queen Elizabeth | Novel compounds |
| US10939692B2 (en) | 2015-10-21 | 2021-03-09 | Cysal Gmbh | Method for culturing aquatic animals with aspartyl-dipeptides |
| ES2930246T3 (es) * | 2015-12-10 | 2022-12-09 | Bharat Biotech Int Ltd | Nuevo compuesto derivado del péptido muramilo, síntesis y utilizaciones del mismo |
| WO2017223337A1 (en) | 2016-06-23 | 2017-12-28 | Nutrivert Llc | Methods to promote growth and improve feed conversion in animals |
| TWI634902B (zh) * | 2017-10-28 | 2018-09-11 | 醫療財團法人徐元智先生醫藥基金會亞東紀念醫院 | Use of glucosamine peptide compounds for the treatment of abnormal liver metabolism |
| WO2020019128A1 (zh) | 2018-07-23 | 2020-01-30 | 深圳市健元医药科技有限公司 | 丙氨酸—赖氨酸—谷氨酸三肽衍生物及其应用 |
| PL4126040T3 (pl) | 2020-03-26 | 2025-04-28 | Nutrivert Inc. | Lipofilowe enancjomery deacetyloglukozamino–muramylodipeptydu o aktywności przeciwzapalnej i wspomagającej wzrost |
-
2021
- 2021-03-25 PL PL21774898.7T patent/PL4126040T3/pl unknown
- 2021-03-25 WO PCT/US2021/024142 patent/WO2021195372A1/en not_active Ceased
- 2021-03-25 AU AU2021241625A patent/AU2021241625B2/en active Active
- 2021-03-25 CA CA3172936A patent/CA3172936A1/en active Pending
- 2021-03-25 BR BR112022019202A patent/BR112022019202A2/pt unknown
- 2021-03-25 KR KR1020227036717A patent/KR102897673B1/ko active Active
- 2021-03-25 JP JP2022558084A patent/JP7667177B2/ja active Active
- 2021-03-25 ES ES21774898T patent/ES3014076T3/es active Active
- 2021-03-25 EP EP21774898.7A patent/EP4126040B1/en active Active
- 2021-03-25 US US17/912,647 patent/US12492222B2/en active Active
- 2021-03-25 CN CN202180038086.5A patent/CN115605226A/zh active Pending
- 2021-03-25 MX MX2022011751A patent/MX2022011751A/es unknown
-
2022
- 2022-09-23 ZA ZA2022/10586A patent/ZA202210586B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021241625B2 (en) | 2025-04-24 |
| US20230174577A1 (en) | 2023-06-08 |
| CN115605226A (zh) | 2023-01-13 |
| EP4126040B1 (en) | 2025-02-19 |
| NZ792610A (en) | 2025-07-25 |
| JP7667177B2 (ja) | 2025-04-22 |
| EP4126040A1 (en) | 2023-02-08 |
| EP4126040C0 (en) | 2025-02-19 |
| ES3014076T3 (en) | 2025-04-16 |
| ZA202210586B (en) | 2023-05-31 |
| KR20220158773A (ko) | 2022-12-01 |
| BR112022019202A2 (pt) | 2022-11-08 |
| AU2021241625A1 (en) | 2022-11-10 |
| EP4126040A4 (en) | 2024-04-24 |
| JP2023518973A (ja) | 2023-05-09 |
| WO2021195372A1 (en) | 2021-09-30 |
| US12492222B2 (en) | 2025-12-09 |
| MX2022011751A (es) | 2022-12-02 |
| KR102897673B1 (ko) | 2025-12-09 |
| CA3172936A1 (en) | 2021-09-30 |
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