JP2011510045A - 動物においてグラム陽性バクテリアにより引き起こされる感染症の予防及び処置の為のラクチレート - Google Patents
動物においてグラム陽性バクテリアにより引き起こされる感染症の予防及び処置の為のラクチレート Download PDFInfo
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- JP2011510045A JP2011510045A JP2010543505A JP2010543505A JP2011510045A JP 2011510045 A JP2011510045 A JP 2011510045A JP 2010543505 A JP2010543505 A JP 2010543505A JP 2010543505 A JP2010543505 A JP 2010543505A JP 2011510045 A JP2011510045 A JP 2011510045A
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- A—HUMAN NECESSITIES
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Abstract
【選択図】なし
Description
式1
に従うラクチレート又はそのNa、K、Ca、Mg、Fe(II)、Zn、NH4、若しくはCu(II)の塩、
式2
のグリコリレート又はそのNa、K、Ca、Mg、Fe(II)、Zn、NH4、若しくはCu(II)の塩、
式3
のラクテートエステル、
及び/又は式4
のグリコール酸エステル
から選ばれる抗バクテリア化合物が使用され、
ここで上記式においてR1がHから選択され、nは1〜10の値の整数を表し、且つ、R2は分枝していてよく又は分枝していなくてもよいC1〜C35のアルキル又はアルケニル鎖を表す。
1日齢のオスのRoss 308ブロイラー鶏が、Probroed & Sloot B.V.(オランダ)により供給された。0日目で、ブロイラーが、Animal Health Service(Deventer、オランダ)の研究施設に到着し、そして、個別の計量後に、消化性ケージ(digestibility cages)中に収容された。重量クラスシステムに基づき、19の鳥が30のSchothorstわら床(litter floor)消化性ケージに割り当てられ、1ケージ当たり同様の平均体重を結果した。ブロイラーは、これらのケージ中で、20日目での実験の終わりまで収容された。9日目で、もし死亡が発生しなければ、鶏の数は、17へと標準化され、そして、鳥の体重が再度測定された。第一に、明らかな視覚上の異常を有する鳥は除かれ、そして第二に、鳥は無作為に除かれて17へと数を減少させた。実験期間を通じての照明及び温度のスケジュールは以下の通りであった、0日目〜9日目の第一の期間において、22時間の照明に続き2時間の暗闇、続いて実験の残りを通じて18時間の照明及び6時間の暗闇。環境温度は、開始での32℃から、実験の終わりでの25℃へと徐々に減少された。
ブロイラーは、到着の日から9日目までコムギ/大豆粉末に基づくスターター食餌(starter diet)を供給された。9日目以降は、コムギ/オオムギに基づくグローワー食餌(grower diet)が、実験の終わり(20日目)まで与えられた。グローワー飼料は、飼料製造後の試験製品における均一な混合の必要性の故に、粉末として与えられた。食餌は、抗コクシジウム剤を何も含まず、試験製品以外の抗微生物性飼料添加物を何も含まなかった。該実験食餌の栄養組成は、ブロイラーの栄養要求を満たすために、オランダの基準に従った(CVB、2006)。
9日目で、ブロイラーは、5時間の飼料離脱期間後に、1mlの生理食塩水又はE.maxima(1ml中に、10.000の胞子形成オーシスト/鶏)のいずれかを接種された。14日目から先は、ブロイラーは、1mlの肝臓ブロス(DIFCO)又はC.perfringensを1日当たり1回、続く3日間、5時間の飼料脱離後に、接種された。種々の処置の詳細な概説は表1に提示されている。
Clostridium perfringens:大きな(gross)及び顕微鏡的な病変が一般に、小腸に発生し、特に近位部(the proximal site)に、発生する。以下のスコアリング方法が用いられた:
0:病変無し
1:1〜5の小さな病変(1mm未満の直径のスポット)
2:5超の小さな病変(1mm未満の直径のスポット)又は1〜5のより大きな病変(1〜2mmの直径のスポット)
3:5超のより大きな病変(1〜2mmの直径)又はびらん性領域
4:死亡した鳥、死亡後に陽性の壊死性腸炎との診断を有する
全ての鳥は、「盲検法(blind)」でスコア化された。すなわち、病変について鳥をスコア化する人は、該鳥の処置の知識を有さなかった。
実験の間、以下のパラメーターが測定された:
・到着の日での個別の体重及び、実験の9日目及び20日目でのケージ当たりの平均
・死体解剖の前の鳥の体重
・0〜9日目の期間のケージ当たりの飼料摂取量及び9〜20日齢(from 9-20 days of age)の日ごとの飼料摂取量
・実験の15日目、16日目及び20日目での処置当たりの24の鳥の小腸粘膜におけるコクシジウム症の病変及び壊死性腸炎病変(処置当たり72の鳥の合計)
・0〜20日齢(from 0 to 20 days of age)のケージ当たりの死亡率
全てのルーチンの研究活動、健康異常の日ごとの記録、及び死亡率の日ごとの記録(その最もあり得る原因を伴う)が、維持された。
生のデータが、外れ値(outliers)について分析された。有意な外れ値が該統計分析から除外された。NE−病変の発生率(感染した鳥の%)が、フィッシャーの正確確立検定(Fisher Exact Test)により分析され、一方で病変の重症度及び日毎の飼料摂取量測定は、Genstat統計ソフトウェアを用いて、分散分析(ANOVA)により分析された。処置の平均が、最小有意差(LSD)により比較された。P≦0.05が、統計的に有意であるとみなされる一方で、0.05<P≦0.10は有意に近いトレンドであるとみなされた。
表2において、陽性とスコア化された鳥(NE病変を有する鳥)のパーセンテージが、すべての陽性とスコア化された鳥の平均病変スコアと同様に与えられる。すべての試験された鳥の平均病変スコア(感染した及び感染していない)が、母集団についてのより代表的な像を与えるので、統計的分析は、これらの結果にわたって実施された(表2の第5カラムを参照されたい)。陽性及び陰性とスコア化された鳥の両方における病変の重症度が、0〜4のスケールで示される(段落「病変スコアリング」を参照されたい)。
表3において、陽性とスコア化された鳥のパーセンテージ及び鳥の平均病変スコアが、16日目について与えられる。
20日目で、有意な差異は、処置の間で観察されなかった。すべての処置が、少なくとも顕微鏡評価に基づき、0%発生率及び病変重症度について明らかに0.0を伴い、NEから回復させた。
死亡率は、集団におけるClostridiumによる感染症の重症度を測定する為のパラメーターの一つである。この実験において、死亡率は、処置間で比較された。死亡率は、感染した対照処置(処置2)において14.6%であり、そして、感染していない対照において0%であった。試験混合物の補給は、死亡率の減少を結果した(5.1%)。
病変スコアリングに加えて、体重及び日毎の飼料摂取量のような生産パラメーターが、試験期間中に測定された。
Claims (10)
- 動物においてグラム陽性バクテリアにより引き起こされる腸感染症を処置し又は予防する為に、
式1
に従うラクチレート又はそのNa、K、Ca、Mg、Fe(II)、Zn、NH4、若しくはCu(II)の塩、
式2
のグリコリレート又はそのNa、K、Ca、Mg、Fe(II)、Zn、NH4、若しくはCu(II)の塩、
式3
のラクテートエステル、
及び/又は
式4
のグリコール酸エステル
から選ばれる抗バクテリア化合物を使用する方法、
ここで上記式においてR1がHから選択され、nは1〜10の値の整数を表し、且つ、R2は分枝していてもよく又は分枝していなくてもよいC1〜C35のアルキル又はアルケニル鎖を表す。 - 該抗バクテリア化合物が、式1のラクチレート又はそのNa、K、Ca、Mg、Fe(II)、Zn、NH4、若しくはCu(II)の塩である、請求項1に記載の方法。
- R2がC6〜C18のアルキル又はアルケニル鎖である、請求項1又は2に記載の方法。
- nが1、2、又は3である、請求項1又は2に記載の方法。
- 動物においてグラム陽性バクテリアにより引き起こされる腸感染症を予防し又は処置する為の、請求項1〜4のいずれか1項に定義された抗バクテリア化合物。
- 動物においてグラム陽性バクテリアにより引き起こされる腸感染症を予防し又は処置する為の組成物の製造の為に、請求項1〜4のいずれか1項に定義された抗微生物性化合物を使用する方法。
- 請求項1〜4のいずれか1項に定義された抗微生物性化合物を含む、動物においてグラム陽性バクテリアにより引き起こされる腸感染症を予防し又は処置する為の動物栄養組成物。
- 請求項1〜4のいずれか1項に定義された抗微生物性化合物の有効量を動物に与えることを含む、動物においてグラム陽性バクテリアにより引き起こされる腸感染症を予防し又は処置する為の方法。
- 該グラム陽性バクテリアがClostridia属のものである、請求項1〜8のいずれか1項に記載された使用方法、化合物、動物栄養組成物、又は方法。
- 該動物がウシ又は家禽から選ばれる、請求項1〜9のいずれか1項に記載の使用方法、化合物、動物栄養組成物、又は方法。
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JP2014520518A (ja) * | 2011-07-08 | 2014-08-25 | ピュラック バイオケム ビー. ブイ. | 飼料製品における使用の為の活性組成物 |
KR102196004B1 (ko) * | 2011-07-08 | 2020-12-31 | 푸락 바이오켐 비.브이. | 사료 산물에 사용하기 위한 활성 제형 |
JP2019531066A (ja) * | 2016-09-06 | 2019-10-31 | ピュラック バイオケム ビー. ブイ. | 発酵における感染に対する脂肪酸エステル |
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US12031171B2 (en) | 2016-09-06 | 2024-07-09 | Purac Biochem B.V. | Fatty acid esters against infections in fermentations |
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US10898457B2 (en) | 2021-01-26 |
EP2249824B1 (en) | 2014-07-16 |
BRPI0906503B8 (pt) | 2021-05-25 |
RU2484818C2 (ru) | 2013-06-20 |
US11517551B2 (en) | 2022-12-06 |
ES2505140T3 (es) | 2014-10-09 |
AU2009207626B2 (en) | 2014-07-24 |
EP2082739A1 (en) | 2009-07-29 |
US20180193301A1 (en) | 2018-07-12 |
AU2009207626A1 (en) | 2009-07-30 |
CN101917984A (zh) | 2010-12-15 |
CA2712448C (en) | 2017-01-03 |
US11517550B2 (en) | 2022-12-06 |
RU2010133717A (ru) | 2012-02-27 |
WO2009092787A1 (en) | 2009-07-30 |
BRPI0906503A2 (pt) | 2015-07-14 |
CA2712448A1 (en) | 2009-07-30 |
AU2009207626B9 (en) | 2015-02-19 |
CN103655536A (zh) | 2014-03-26 |
JP5461432B2 (ja) | 2014-04-02 |
BRPI0906503B1 (pt) | 2019-06-25 |
CN101917984B (zh) | 2014-03-26 |
MX2010008010A (es) | 2010-08-10 |
EP2249824A1 (en) | 2010-11-17 |
PL2249824T3 (pl) | 2014-12-31 |
US20100311832A1 (en) | 2010-12-09 |
US20190046494A1 (en) | 2019-02-14 |
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