JP2023517944A5 - - Google Patents

Info

Publication number
JP2023517944A5
JP2023517944A5 JP2022554500A JP2022554500A JP2023517944A5 JP 2023517944 A5 JP2023517944 A5 JP 2023517944A5 JP 2022554500 A JP2022554500 A JP 2022554500A JP 2022554500 A JP2022554500 A JP 2022554500A JP 2023517944 A5 JP2023517944 A5 JP 2023517944A5
Authority
JP
Japan
Prior art keywords
alkyl
pharmaceutically acceptable
tautomer
stereoisomer
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022554500A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023517944A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2021/056023 external-priority patent/WO2021180774A1/en
Publication of JP2023517944A publication Critical patent/JP2023517944A/ja
Publication of JP2023517944A5 publication Critical patent/JP2023517944A5/ja
Pending legal-status Critical Current

Links

JP2022554500A 2020-03-11 2021-03-10 統合的ストレス応答経路の調節因子 Pending JP2023517944A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20162329.5 2020-03-11
EP20162329 2020-03-11
PCT/EP2021/056023 WO2021180774A1 (en) 2020-03-11 2021-03-10 Modulators of the integrated stress response pathway

Publications (2)

Publication Number Publication Date
JP2023517944A JP2023517944A (ja) 2023-04-27
JP2023517944A5 true JP2023517944A5 (enExample) 2024-03-13

Family

ID=69804610

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022554500A Pending JP2023517944A (ja) 2020-03-11 2021-03-10 統合的ストレス応答経路の調節因子

Country Status (11)

Country Link
US (1) US12441720B2 (enExample)
EP (1) EP4117780B1 (enExample)
JP (1) JP2023517944A (enExample)
KR (1) KR20220151635A (enExample)
CN (1) CN115190813B (enExample)
AU (1) AU2021236284B2 (enExample)
BR (1) BR112022014706A2 (enExample)
CA (1) CA3165813A1 (enExample)
IL (1) IL296220A (enExample)
MX (1) MX2022011143A (enExample)
WO (1) WO2021180774A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3137212A1 (en) * 2019-04-23 2020-10-29 Evotec International Gmbh Modulators of the integrated stress response pathway
AU2021363616B2 (en) * 2020-10-22 2026-03-26 Evotec International Gmbh Modulators of the integrated stress response pathway
KR20230110509A (ko) 2020-10-22 2023-07-24 에보텍 인터내셔널 게엠베하 통합 스트레스 반응 경로의 조절제
MX2023004626A (es) 2020-10-22 2023-05-23 Evotec Int Gmbh Moduladores de la via de respuesta integrada al estres.
WO2024109736A1 (zh) * 2022-11-21 2024-05-30 深圳众格生物科技有限公司 一种化合物、包含其的药物组合物及其合成方法和用途
DE102023120315A1 (de) * 2023-07-31 2025-02-06 Rheinisch-Westfälische Technische Hochschule Aachen, abgekürzt RWTH Aachen, Körperschaft des öffentlichen Rechts Verfahren zur Herstellung von Pyrrolidon-substituierten Polyolen

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0988301B1 (en) 1997-06-12 2006-08-09 Aventis Pharma Limited Imidazolyl-cyclic acetals
JP6806562B2 (ja) 2013-03-15 2021-01-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア eIF2α経路の調節因子
TW201808888A (zh) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
TW201808903A (zh) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
TW201808914A (zh) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
TWI763668B (zh) 2016-05-05 2022-05-11 美商嘉來克生命科學有限責任公司 整合應激途徑之調節劑
KR20190015748A (ko) 2016-06-08 2019-02-14 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Atf4 경로 억제제로서의 화학적 화합물
KR20190015492A (ko) 2016-06-08 2019-02-13 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 화학적 화합물
WO2018225093A1 (en) 2017-06-07 2018-12-13 Glaxosmithkline Intellectual Property Development Limited Chemical compounds as atf4 pathway inhibitors
CA3068753A1 (en) 2017-07-03 2019-01-10 Glaxosmithkline Intellectual Property Development Limited N-(3-(2-(4-chlorophenoxy)acetamido)bicyclo[1.1.1]pentan-1-yl)-2-cyclobutane-1-carboxamide derivatives and related compounds as atf4 inhibitors for treating cancer and other diseases
CA3068395A1 (en) 2017-07-03 2019-01-10 Glaxosmithkline Intellectual Property Development Limited 2-(4-chlorophenoxy)-n-((1-(2-(4-chlorophenoxy)ethynazetidin-3-yl)methyl)acetamide derivatives and related compounds as atf4 inhibitors for treating cancer and other diseases
CR20200054A (es) 2017-08-09 2020-03-21 Denali Therapeutics Inc Compuestos, composiciones y métodos
HUE062446T2 (hu) * 2017-09-01 2023-11-28 Denali Therapeutics Inc Vegyületek, készítmények és eljárások
JP2021501785A (ja) 2017-11-02 2021-01-21 カリコ ライフ サイエンシーズ エルエルシー 統合的ストレス経路の調節剤
UY37957A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
AU2018358157B2 (en) 2017-11-02 2023-03-09 Abbvie Inc. Modulators of the integrated stress pathway
CA3080948A1 (en) 2017-11-02 2019-05-09 Calico Life Sciences Llc Modulators of the integrated stress pathway
UY37956A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
SG11202004009TA (en) * 2017-11-02 2020-05-28 Calico Life Sciences Llc Modulators of the integrated stress pathway
WO2019090078A1 (en) 2017-11-02 2019-05-09 Calico Life Sciences Llc Modulators of the integrated stress pathway
UY37958A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
EP3704089B1 (en) 2017-11-02 2023-07-19 Calico Life Sciences LLC Modulators of the integrated stress pathway
AU2018383675A1 (en) 2017-12-13 2020-07-09 Altos Labs, Inc. Inhibitors of integrated stress response pathway
EP3768660A1 (en) 2018-03-23 2021-01-27 Denali Therapeutics Inc. Modulators of eukaryotic initiation factor 2
WO2019193541A1 (en) 2018-04-06 2019-10-10 Glaxosmithkline Intellectual Property Development Limited Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors
WO2019193540A1 (en) 2018-04-06 2019-10-10 Glaxosmithkline Intellectual Property Development Limited Heteroaryl derivatives of formula (i) as atf4 inhibitors
MX2020013269A (es) 2018-06-05 2021-02-18 Praxis Biotech LLC Inhibidores de la vía de respuesta al estrés integrada.
EP3820843A1 (en) 2018-07-09 2021-05-19 GlaxoSmithKline Intellectual Property Development Limited Chemical compounds
WO2020031107A1 (en) 2018-08-08 2020-02-13 Glaxosmithkline Intellectual Property Development Limited Chemical compounds
TWI771621B (zh) 2018-10-11 2022-07-21 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
MA54959A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
EP3923935A4 (en) 2019-02-13 2022-10-26 Denali Therapeutics Inc. COMPOUNDS, COMPOSITIONS AND METHODS
CN113840597A (zh) 2019-02-25 2021-12-24 普拉西斯生物技术有限责任公司 整合应激反应通路抑制剂
WO2020181247A1 (en) 2019-03-06 2020-09-10 Denali Therapeutics Inc. Compounds, compositions and methods
CA3137212A1 (en) 2019-04-23 2020-10-29 Evotec International Gmbh Modulators of the integrated stress response pathway
IL287379B2 (en) 2019-04-23 2025-11-01 Evotec Int Gmbh Modulators of the integrated stress response pathway
PE20220572A1 (es) 2019-04-30 2022-04-20 Calico Life Sciences Llc Moduladores de la via integrada del estres
EP3962899A1 (en) 2019-04-30 2022-03-09 Calico Life Sciences LLC Substituted cyclolakyls as modulators of the integrated stress pathway
KR20220024486A (ko) 2019-06-12 2022-03-03 프락시스 바이오테크 엘엘씨 통합 스트레스 반응 경로의 억제제
CN114466654A (zh) 2019-06-12 2022-05-10 普拉西斯生物技术有限责任公司 整合应激反应通路调节剂
EP4096665A1 (en) 2020-01-28 2022-12-07 Evotec International GmbH Modulators of the integrated stress response pathway
KR20230110509A (ko) 2020-10-22 2023-07-24 에보텍 인터내셔널 게엠베하 통합 스트레스 반응 경로의 조절제
MX2023004626A (es) 2020-10-22 2023-05-23 Evotec Int Gmbh Moduladores de la via de respuesta integrada al estres.
AU2021363616B2 (en) 2020-10-22 2026-03-26 Evotec International Gmbh Modulators of the integrated stress response pathway

Similar Documents

Publication Publication Date Title
JP2022530049A5 (enExample)
JP2023511616A5 (enExample)
JP2022530051A5 (enExample)
JP2006514925A5 (enExample)
JP2013519680A5 (enExample)
JP2022531446A5 (enExample)
JP2014525444A5 (enExample)
JP2009523165A5 (enExample)
JP2010533160A5 (enExample)
JP2005526028A5 (enExample)
JP2009534404A5 (enExample)
CA2718383A1 (en) Heteroaryl-substituted dicyanopyridines and use thereof for treatment of cardiovascular diseases
HRP20191140T1 (hr) Spojevi i pripravci kao inhibitori c-kit kinaze
JP2009534406A5 (enExample)
JP2020516671A5 (enExample)
JP2013530240A5 (enExample)
JP2013517281A5 (enExample)
JP2007531752A5 (enExample)
JP2009534405A5 (enExample)
RU2485114C2 (ru) Карбоксамидные соединения и их применение в качестве ингибиторов кальпаинов
JP2016512515A5 (enExample)
JP2023506899A5 (enExample)
JP2022508218A5 (enExample)
JP2018503661A5 (enExample)
JP2016540811A5 (enExample)