JP2023514242A5 - - Google Patents
Info
- Publication number
- JP2023514242A5 JP2023514242A5 JP2022548941A JP2022548941A JP2023514242A5 JP 2023514242 A5 JP2023514242 A5 JP 2023514242A5 JP 2022548941 A JP2022548941 A JP 2022548941A JP 2022548941 A JP2022548941 A JP 2022548941A JP 2023514242 A5 JP2023514242 A5 JP 2023514242A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- nucleic acid
- acid molecule
- seq
- nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062975400P | 2020-02-12 | 2020-02-12 | |
| US62/975,400 | 2020-02-12 | ||
| PCT/US2021/017950 WO2021163556A1 (en) | 2020-02-12 | 2021-02-12 | Compositions and methods for inducible alternative splicing regulation of gene expression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023514242A JP2023514242A (ja) | 2023-04-05 |
| JP2023514242A5 true JP2023514242A5 (https=) | 2024-02-21 |
| JP7728772B2 JP7728772B2 (ja) | 2025-08-25 |
Family
ID=77292961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022548941A Active JP7728772B2 (ja) | 2020-02-12 | 2021-02-12 | 遺伝子発現の誘導性選択的スプライシング調節のための組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230340498A1 (https=) |
| EP (1) | EP4103717A4 (https=) |
| JP (1) | JP7728772B2 (https=) |
| KR (1) | KR20220146501A (https=) |
| CN (1) | CN115605596A (https=) |
| AU (1) | AU2021218807A1 (https=) |
| CA (1) | CA3167836A1 (https=) |
| IL (1) | IL295542A (https=) |
| WO (1) | WO2021163556A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210355509A1 (en) * | 2018-08-07 | 2021-11-18 | The Children's Hospital Of Philadelphia | Alternative splicing regulation of gene expression and therapeutic methods |
| US20250129390A1 (en) * | 2021-09-30 | 2025-04-24 | Osaka University | Method for producing cell having dna deletion specific to one of homologous chromosomes |
| EP4419692A4 (en) * | 2021-10-22 | 2025-10-01 | Fred Hutchinson Cancer Center | SYNTHETIC INTRONS FOR TARGETED GENE EXPRESSION |
| US20250303000A1 (en) | 2022-05-18 | 2025-10-02 | The Children's Hospital Of Philadelphia | Compositions and methods for inducible alternative splicing regulation of gene expression |
| WO2024060205A1 (zh) * | 2022-09-23 | 2024-03-28 | 北京基驭医疗科技有限公司 | 包含基于小分子药物的可变剪接调节元件的核酸分子 |
| EP4627095A2 (en) * | 2022-11-28 | 2025-10-08 | Siren Biotechnology, Inc. | Gene therapy vectors for treatment of cancer |
| WO2024173699A2 (en) * | 2023-02-16 | 2024-08-22 | Mammoth Biosciences, Inc. | Compositions for the treatment of spinal muscular atrophy |
| WO2024186892A2 (en) * | 2023-03-06 | 2024-09-12 | The Children's Hospital Of Philadelphia | Regulated control of rna interference by alternative splicing |
| EP4701634A1 (en) | 2023-04-28 | 2026-03-04 | Kriya Therapeutics, Inc. | Riboswitches for regulating gene expression and therapeutic methods of using the same |
| WO2024251925A1 (en) | 2023-06-09 | 2024-12-12 | F. Hoffmann-La Roche Ag | Inducible gene expression system |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7838657B2 (en) * | 2004-12-03 | 2010-11-23 | University Of Massachusetts | Spinal muscular atrophy (SMA) treatment via targeting of SMN2 splice site inhibitory sequences |
| GB2443186A (en) * | 2006-10-25 | 2008-04-30 | Oxitec Ltd | Expression system for mediating alternative splicing |
| WO2009151546A2 (en) * | 2008-05-27 | 2009-12-17 | Ptc Therapeutics, Inc. | Methods for treating spinal muscular atrophy |
| DK2812004T3 (en) * | 2012-02-10 | 2018-10-15 | Ptc Therapeutics Inc | COMPOUNDS FOR TREATMENT OF SPINAL MUSCLE DROPHY |
| ES2771862T3 (es) * | 2013-10-28 | 2020-07-07 | Invectys | Una vacuna de ADN que codifica telomerasa |
| CN108603230A (zh) * | 2015-10-09 | 2018-09-28 | 南安普敦大学 | 基因表达的调节与蛋白质表达失调的筛选 |
| EA201991309A1 (ru) * | 2016-11-28 | 2019-11-29 | Способы модуляции сплайсинга рнк | |
| US20210355509A1 (en) * | 2018-08-07 | 2021-11-18 | The Children's Hospital Of Philadelphia | Alternative splicing regulation of gene expression and therapeutic methods |
| EP4004213A1 (en) * | 2019-07-25 | 2022-06-01 | Novartis AG | Regulatable expression systems |
| WO2022204471A1 (en) * | 2021-03-26 | 2022-09-29 | Ptc Therapeutics Inc. | Regulation of transgene expression using a small molecule inducible splicing switch |
-
2021
- 2021-02-12 CN CN202180027946.5A patent/CN115605596A/zh active Pending
- 2021-02-12 US US17/798,851 patent/US20230340498A1/en active Pending
- 2021-02-12 WO PCT/US2021/017950 patent/WO2021163556A1/en not_active Ceased
- 2021-02-12 KR KR1020227031120A patent/KR20220146501A/ko active Pending
- 2021-02-12 EP EP21754225.7A patent/EP4103717A4/en active Pending
- 2021-02-12 JP JP2022548941A patent/JP7728772B2/ja active Active
- 2021-02-12 IL IL295542A patent/IL295542A/en unknown
- 2021-02-12 CA CA3167836A patent/CA3167836A1/en active Pending
- 2021-02-12 AU AU2021218807A patent/AU2021218807A1/en active Pending
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