JP2023513507A - 新規なラクトバチルスサケイhem224菌株、及び上記菌株又はその培養物を含む炎症又は喘息の治療用組成物 - Google Patents
新規なラクトバチルスサケイhem224菌株、及び上記菌株又はその培養物を含む炎症又は喘息の治療用組成物 Download PDFInfo
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Abstract
Description
実施例1:ラクトバチルスサケイHEM224の抗炎症及び喘息治療効果の確認(In-vitro)
本願の新規な菌株であるラクトバチルスサケイHEM224(Lactobacillus sakei HEM224、寄託機関:韓国生命工学研究院韓国生物資源センター、受託番号:KCTC14065BP、受託日:2019年12月10日)の抗炎症効果及び喘息の治療及び予防効果を細胞レベルで確認するために、下記のような実験を行った。
本願の新規な菌株であるラクトバチルスサケイHEM224の抗炎症効果及び喘息の治療及び予防効果を動物レベルで確認するために、下記のような実験を行った。
上記から得られた肺組織からIL-4及びIL-5の発現レベルを確認するために、下記のような実験を行った。
上記得られた肺胞洗浄液(Bronchoalveolar lavage fluid、BALF)からIL-4及びIL-5の発現レベルを確認するために、下記のような実験を行った。
上記得られた血清(Serum)からIgEの発現レベルを確認するために、下記のような実験を行った。
Claims (7)
- ラクトバチルスサケイ(Lactobacillus sakei)HEM224菌株(KCTC14065BP)。
- 前記菌株は、前炎症性又は炎症性因子の生成を抑制する、請求項1に記載の菌株。
- 前記菌株は、抗炎症性因子の生成を促進する、請求項1に記載の菌株。
- 前記菌株は、炎症性疾患を治療、改善、緩和又は予防できるものである、請求項1に記載の菌株。
- 前記炎症性疾患は、喘息、アレルギー性及び非アレルギー性鼻炎、慢性及び急性鼻炎、皮膚炎、アトピー性皮膚炎及び副鼻腔炎から構成された群より選択された1つ以上である、請求項4に記載の菌株。
- ラクトバチルスサケイ(Lactobacillus sakei)HEM224菌株(KCTC14065BP)又はその培養物を有効成分として含む、炎症又は喘息の改善又は予防用食品組成物。
- ラクトバチルスサケイ(Lactobacillus sakei)HEM224菌株(KCTC14065BP)又はその培養物を有効成分として含む、炎症又は喘息の治療又は予防用薬学組成物。
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KR10-2020-0013674 | 2020-02-05 | ||
KR1020200013674A KR102325947B1 (ko) | 2020-02-05 | 2020-02-05 | 신규한 락토바실러스 사케이 hem224 균주, 및 상기 균주 또는 이의 배양물을 포함하는 염증 또는 천식의 치료용 조성물 |
PCT/KR2020/019432 WO2021157867A1 (ko) | 2020-02-05 | 2020-12-30 | 신규한 락토바실러스 사케이 hem224 균주, 및 상기 균주 또는 이의 배양물을 포함하는 염증 또는 천식의 치료용 조성물 |
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KR102573675B1 (ko) * | 2021-12-28 | 2023-09-01 | 한국식품연구원 | 라티락토바실러스 사케아이 WiKim0142를 포함하는 염증성 질환의 예방, 개선 또는 치료용 조성물 |
KR20230161901A (ko) | 2022-05-19 | 2023-11-28 | 부산대학교 산학협력단 | 락토바실러스 사케이 cvl-001에 의해 인터루킨 10 생산이 증가된 중간엽 줄기세포를 유효성분으로 포함하는 염증성 질환 예방 또는 치료용 약학 조성물 |
WO2023224426A1 (ko) * | 2022-05-19 | 2023-11-23 | 부산대학교 산학협력단 | 락토바실러스 사케이 cvl-001에 의해 인터루킨 10 생산이 증가된 중간엽 줄기세포를 유효성분으로 포함하는 염증성 질환 예방 또는 치료용 약학 조성물 |
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JOURNALOF FUNCTIONAL FOODS, vol. 29, JPN6023032024, 2017, pages 256 - 268, ISSN: 0005125622 * |
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CN115087728A (zh) | 2022-09-20 |
JP7432745B2 (ja) | 2024-02-16 |
EP4095231A4 (en) | 2024-04-17 |
EP4095231A1 (en) | 2022-11-30 |
KR102325947B1 (ko) | 2021-11-15 |
CN115087728B (zh) | 2024-06-07 |
KR20210099833A (ko) | 2021-08-13 |
WO2021157867A1 (ko) | 2021-08-12 |
US20230025456A1 (en) | 2023-01-26 |
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