JP2023511524A - Ｈｍｏ産生 - Google Patents

Ｈｍｏ産生 Download PDF

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Publication number
JP2023511524A
JP2023511524A JP2022540698A JP2022540698A JP2023511524A JP 2023511524 A JP2023511524 A JP 2023511524A JP 2022540698 A JP2022540698 A JP 2022540698A JP 2022540698 A JP2022540698 A JP 2022540698A JP 2023511524 A JP2023511524 A JP 2023511524A
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JP
Japan
Prior art keywords
lacto
lnfp
nucleic acid
fucopentaose
lnt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022540698A
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English (en)
Japanese (ja)
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JP2023511524A5 (https=
JPWO2021148610A5 (https=
Inventor
マノス パパダキス，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glycom AS
Original Assignee
Glycom AS
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Publication date
Application filed by Glycom AS filed Critical Glycom AS
Publication of JP2023511524A publication Critical patent/JP2023511524A/ja
Publication of JP2023511524A5 publication Critical patent/JP2023511524A5/ja
Publication of JPWO2021148610A5 publication Critical patent/JPWO2021148610A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2022540698A 2020-01-23 2021-01-22 Ｈｍｏ産生 Pending JP2023511524A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA202000088 2020-01-23
DKPA202000088 2020-01-23
PCT/EP2021/051466 WO2021148610A1 (en) 2020-01-23 2021-01-22 Hmo production

Publications (3)

Publication Number Publication Date
JP2023511524A true JP2023511524A (ja) 2023-03-20
JP2023511524A5 JP2023511524A5 (https=) 2023-09-22
JPWO2021148610A5 JPWO2021148610A5 (https=) 2023-09-22

Family

ID=74505190

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022540698A Pending JP2023511524A (ja) 2020-01-23 2021-01-22 Ｈｍｏ産生

Country Status (6)

Country Link
US (1) US20230109661A1 (https=)
EP (1) EP4093748A1 (https=)
JP (1) JP2023511524A (https=)
CN (1) CN114981291B (https=)
BR (1) BR112022014420A2 (https=)
WO (1) WO2021148610A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK181497B1 (en) 2021-05-17 2024-03-12 Dsm Ip Assets Bv ENHANCING FORMATION OF THE HMOS LNT AND/OR LNnT BY MODIFYING LACTOSE IMPORT IN THE CELL
DK181991B1 (en) 2021-11-11 2025-05-15 Dsm Ip Assets Bv Combined fermentation process for producing one or more human milk oligosaccharide(s) (hmo(s)) in escherichia coli
US20260028634A1 (en) 2022-03-02 2026-01-29 Dsm Ip Assets B.V. New sialyltransferases for in vivo synthesis of 3'sl and 6'sl
DK181319B1 (en) 2022-03-02 2023-08-10 Dsm Ip Assets Bv Genetically engineered cells and methods comprising use of a sialyltransferase for in vivo synthesis of 3’sl
DK181683B1 (en) 2022-03-02 2024-09-20 Dsm Ip Assets Bv Cells exprssing new sialyltransferases for in vivo synthesis of lst-a, methods using same and constructs encoding said sialyltransferases
US20250290078A1 (en) 2022-04-29 2025-09-18 Dsm Ip Assets B.V. Hmo producing microorganism with increased robustness towards glucose gradients
EP4577061A1 (en) 2022-08-25 2025-07-02 DSM IP Assets B.V. Hybrid method for producing complex hmos
WO2024110667A1 (en) 2022-11-25 2024-05-30 Dsm Ip Assets B.V. Two-strain system for producing oligosaccharides
CN120677242A (zh) 2023-02-24 2025-09-19 帝斯曼知识产权资产管理有限公司 用于体内合成人乳寡糖的产物特异性转运蛋白
DK181822B1 (en) 2023-06-07 2025-01-30 Dsm Ip Assets Bv Genetically engineered strains with reduced byproduct formation and methods and uses of same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017509346A (ja) * 2014-03-31 2017-04-06 イェンネワイン バイオテクノロジー ゲーエムベーハーＪｅｎｎｅｗｅｉｎ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅ ＧｍｂＨ オリゴ糖の全発酵
WO2019123324A1 (en) * 2017-12-21 2019-06-27 Glycom A/S Nucleic acid construct for in vitro and in vivo gene expression
WO2019219578A1 (en) * 2018-05-16 2019-11-21 Jennewein Biotechnologie Gmbh Use of glycosidases in the production of oligosaccharides

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2440661T3 (en) * 2009-06-08 2018-03-12 Jennewein Biotechnologie Gmbh HMO synthesis
EP2675899A4 (en) 2011-02-16 2014-09-10 Glycosyn LLC BIOSYNTHESIS OF HUMAN MILK OLIGOSACCHARIDES IN MANIPULATED BACTERIA
DE202015009782U1 (de) 2014-06-11 2020-02-10 Glycom A/S Trennung von 2'-O-Fucosyllactose aus Fermentationsbrühe
EP3191499A4 (en) 2014-09-09 2018-06-06 Glycosyn LLC Alpha (1,3) fucosyltransferases for use in the production of fucosylated oligosaccharides
US10676770B2 (en) 2014-12-16 2020-06-09 Glycom A/S Separation of 2′-FL from a fermentation broth
EP3141610A1 (en) 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Production of human milk oligosaccharides in microbial hosts with engineered import / export
DE202017007249U1 (de) 2016-03-07 2020-04-23 Glycom A/S Abtrennung von Oligosacchariden aus der Fermentationsbrühe
EP4674526A3 (en) 2016-04-19 2026-04-01 Glycom A/S Separation of oligosaccharides from fermentation broth
ES2856749T3 (es) 2016-10-29 2021-09-28 Chr Hansen Hmo Gmbh Proceso para la producción de oligosacáridos fucosilados
US20190323053A1 (en) 2018-04-23 2019-10-24 Dupont Nutrition Biosciences Aps Increasing activity of 2? fucosyllactose transporters endogenous to microbial cells
US20190323052A1 (en) 2018-04-23 2019-10-24 Dupont Nutrition Biosciences Aps Increasing export of 2? fucosyllactose from microbial cells through the expression of a heterologous nucleic acid
US10519475B1 (en) 2018-11-21 2019-12-31 Amyris, Inc. Biosynthesis of compounds in yeast

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017509346A (ja) * 2014-03-31 2017-04-06 イェンネワイン バイオテクノロジー ゲーエムベーハーＪｅｎｎｅｗｅｉｎ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅ ＧｍｂＨ オリゴ糖の全発酵
WO2019123324A1 (en) * 2017-12-21 2019-06-27 Glycom A/S Nucleic acid construct for in vitro and in vivo gene expression
WO2019219578A1 (en) * 2018-05-16 2019-11-21 Jennewein Biotechnologie Gmbh Use of glycosidases in the production of oligosaccharides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"MFS transporter, SET family, sugar efflux transporter [Rosenbergiella nectarea].", DATABASE DDBJ/EMBL/GENBANK [ONLINE], JPN6024034516, 29 October 2016 (2016-10-29), ISSN: 0005534746 *

Also Published As

Publication number Publication date
US20230109661A1 (en) 2023-04-06
BR112022014420A2 (pt) 2022-09-27
WO2021148610A1 (en) 2021-07-29
CN114981291A (zh) 2022-08-30
WO2021148610A9 (en) 2022-04-28
EP4093748A1 (en) 2022-11-30
CN114981291B (zh) 2024-12-06

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