JP2023507575A5 - - Google Patents

Info

Publication number
JP2023507575A5
JP2023507575A5 JP2022537514A JP2022537514A JP2023507575A5 JP 2023507575 A5 JP2023507575 A5 JP 2023507575A5 JP 2022537514 A JP2022537514 A JP 2022537514A JP 2022537514 A JP2022537514 A JP 2022537514A JP 2023507575 A5 JP2023507575 A5 JP 2023507575A5
Authority
JP
Japan
Prior art keywords
glucosidase
acid alpha
recombinant
seq
recombinant acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022537514A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023507575A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/066041 external-priority patent/WO2021127457A1/en
Publication of JP2023507575A publication Critical patent/JP2023507575A/ja
Publication of JP2023507575A5 publication Critical patent/JP2023507575A5/ja
Priority to JP2025050060A priority Critical patent/JP2025089465A/ja
Pending legal-status Critical Current

Links

JP2022537514A 2019-12-20 2020-12-18 操作された酸性アルファ-グルコシダーゼバリアント Pending JP2023507575A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025050060A JP2025089465A (ja) 2019-12-20 2025-03-25 操作された酸性アルファ-グルコシダーゼバリアント

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962951625P 2019-12-20 2019-12-20
US62/951,625 2019-12-20
PCT/US2020/066041 WO2021127457A1 (en) 2019-12-20 2020-12-18 Engineered acid alpha-glucosidase variants

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025050060A Division JP2025089465A (ja) 2019-12-20 2025-03-25 操作された酸性アルファ-グルコシダーゼバリアント

Publications (2)

Publication Number Publication Date
JP2023507575A JP2023507575A (ja) 2023-02-24
JP2023507575A5 true JP2023507575A5 (https=) 2023-12-19

Family

ID=76438815

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022537514A Pending JP2023507575A (ja) 2019-12-20 2020-12-18 操作された酸性アルファ-グルコシダーゼバリアント
JP2025050060A Pending JP2025089465A (ja) 2019-12-20 2025-03-25 操作された酸性アルファ-グルコシダーゼバリアント

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025050060A Pending JP2025089465A (ja) 2019-12-20 2025-03-25 操作された酸性アルファ-グルコシダーゼバリアント

Country Status (17)

Country Link
US (2) US11970722B2 (https=)
EP (1) EP4077679A4 (https=)
JP (2) JP2023507575A (https=)
KR (1) KR20220129547A (https=)
CN (1) CN115427574A (https=)
AR (1) AR120858A1 (https=)
AU (1) AU2020408066A1 (https=)
BR (1) BR112022011760A2 (https=)
CA (1) CA3165484A1 (https=)
CL (1) CL2022001655A1 (https=)
CO (1) CO2022010224A2 (https=)
EC (1) ECSP22056585A (https=)
IL (1) IL294082A (https=)
MX (1) MX2022007399A (https=)
PE (1) PE20221266A1 (https=)
TW (1) TWI901622B (https=)
WO (1) WO2021127457A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202100928QA (en) 2018-08-02 2021-02-25 Dyne Therapeutics Inc Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US12018087B2 (en) 2018-08-02 2024-06-25 Dyne Therapeutics, Inc. Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
JP2023507575A (ja) 2019-12-20 2023-02-24 コデクシス, インコーポレイテッド 操作された酸性アルファ-グルコシダーゼバリアント
CN115820609A (zh) * 2022-11-15 2023-03-21 新乡医学院 一种重组琼胶酶及其基因和应用
CN118667797A (zh) * 2023-03-14 2024-09-20 北京据德医药科技有限公司 一种重组酸性α-葡萄糖苷酶及其用途
WO2024231820A1 (en) 2023-05-05 2024-11-14 Takeda Pharmaceutical Company Limited Treatment of pompe disease
EP4735591A2 (en) * 2023-06-30 2026-05-06 Crosswalk Therapeutics, Inc. Engineered acid alpha-glucosidase variants
WO2025004002A2 (en) 2023-06-30 2025-01-02 Takeda Pharmaceutical Company Limited Treatment of pompe disease
CN117737040B (zh) * 2023-12-08 2025-07-15 深圳市新产业生物医学工程股份有限公司 α-葡萄糖苷酶突变体、试剂盒及其应用

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5928905A (en) 1995-04-18 1999-07-27 Glaxo Group Limited End-complementary polymerase reaction
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6406855B1 (en) 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6165793A (en) 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6395547B1 (en) 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US20060257890A1 (en) 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
FI964808A0 (fi) 1994-06-03 1996-12-02 Novo Nordisk Biotech Inc Puhdistetut Myceliophthora lakkaasit ja niitä koodaavat nukleiinihapot
CN101659926A (zh) 1994-06-30 2010-03-03 诺沃奇梅兹有限公司 非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子
FI104465B (fi) 1995-06-14 2000-02-15 Valio Oy Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
KR100570935B1 (ko) 1997-01-17 2006-04-13 맥시겐, 인크. 반복적 서열 재조합에 의한 전세포 및 유기체의 개량 방법
WO1998031816A1 (en) 1997-01-17 1998-07-23 Regents Of The University Of Minnesota Dna molecules and protein displaying improved triazine compound degrading ability
US7148054B2 (en) 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US6537746B2 (en) 1997-12-08 2003-03-25 Maxygen, Inc. Method for creating polynucleotide and polypeptide sequences
US6484105B2 (en) 1998-04-02 2002-11-19 Maxyag, Inc. Method for obtaining a plant with a genetic lesion in a gene sequence
IL139093A0 (en) 1998-05-01 2001-11-25 Maxygen Inc Optimization of pest resistance genes using dna shuffling
IL140125A0 (en) 1998-06-17 2002-02-10 Maxygen Inc Method for producing polynucleotides with desired properties
US6365408B1 (en) 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
JP2002522072A (ja) 1998-08-12 2002-07-23 マキシジェン, インコーポレイテッド 工業用化学薬品の製造のためのモノオキシゲナーゼ遺伝子のdnaシャッフリング。
JP2002526107A (ja) 1998-10-07 2002-08-20 マキシジェン, インコーポレイテッド マイコトキシンの解毒のための核酸を生成するためのdnaシャッフリング
WO2000028018A1 (en) 1998-11-10 2000-05-18 Maxygen, Inc. Modified adp-glucose pyrophosphorylase for improvement and optimization of plant phenotypes
JP4221100B2 (ja) 1999-01-13 2009-02-12 エルピーダメモリ株式会社 半導体装置
US6917882B2 (en) 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6436675B1 (en) 1999-09-28 2002-08-20 Maxygen, Inc. Use of codon-varied oligonucleotide synthesis for synthetic shuffling
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6368861B1 (en) 1999-01-19 2002-04-09 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US7873477B1 (en) 2001-08-21 2011-01-18 Codexis Mayflower Holdings, Llc Method and system using systematically varied data libraries
US8457903B1 (en) 1999-01-19 2013-06-04 Codexis Mayflower Holdings, Llc Method and/or apparatus for determining codons
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
US20070065838A1 (en) 1999-01-19 2007-03-22 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US7024312B1 (en) 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US7702464B1 (en) 2001-08-21 2010-04-20 Maxygen, Inc. Method and apparatus for codon determining
ES2341217T3 (es) 1999-01-19 2010-06-17 Maxygen, Inc. Recombinacion de acidos nucleicos mediada por oligonucleotidos.
JP2003524394A (ja) 1999-02-11 2003-08-19 マキシジェン, インコーポレイテッド ハイスループット質量分析法
AU3391900A (en) 1999-03-05 2000-09-21 Maxygen, Inc. Encryption of traits using split gene sequences
US6703240B1 (en) 1999-04-13 2004-03-09 Maxygar, Inc. Modified starch metabolism enzymes and encoding genes for improvement and optimization of plant phenotypes
US7430477B2 (en) 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
US6519065B1 (en) 1999-11-05 2003-02-11 Jds Fitel Inc. Chromatic dispersion compensation device
US6686515B1 (en) 1999-11-23 2004-02-03 Maxygen, Inc. Homologous recombination in plants
IL150291A0 (en) 2000-01-11 2002-12-01 Maxygen Inc Integrated systems and methods for diversity generation and screening
EP1272967A2 (en) 2000-03-30 2003-01-08 Maxygen, Inc. In silico cross-over site selection
JP2004508011A (ja) 2000-04-03 2004-03-18 マキシジェン, インコーポレイテッド スブチリシン変異体
EP1463807A4 (en) 2001-12-19 2006-04-12 Bristol Myers Squibb Co FORMATHYDROGENASE FROM PICHIA PASTORIS AND USES THEREOF
JP5319865B2 (ja) 2002-03-01 2013-10-16 コデクシス メイフラワー ホールディングス, エルエルシー 機能的生体分子を同定する方法、システム、およびソフトウェア
US20050084907A1 (en) 2002-03-01 2005-04-21 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US7747391B2 (en) 2002-03-01 2010-06-29 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
EP1488335A4 (en) 2002-03-09 2006-11-15 Maxygen Inc OPTIMIZING CROSSOVER POINTS FOR THE ADJUSTED EVOLUTION
ES2371913T3 (es) 2003-01-22 2012-01-11 Duke University Constructos mejorados para expresar polipéptidos lisosomales.
EP2287326A1 (en) * 2003-08-08 2011-02-23 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
US20080014188A1 (en) 2004-02-06 2008-01-17 Zankel Todd C Manufacture of Highly Phosphorylated Lysosomal Enzymes and Uses Thereof
EP2886658A1 (en) 2005-03-10 2015-06-24 BASF Enzymes LLC Lyase enzymes, nucleic acids encoding them and methods for making and using them
EP3782655A1 (en) 2005-05-17 2021-02-24 Amicus Therapeutics, Inc. A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives
US7531341B1 (en) 2006-06-12 2009-05-12 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US7534595B2 (en) 2006-06-12 2009-05-19 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US7560263B2 (en) 2007-08-17 2009-07-14 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof
EP2250594B1 (en) 2008-02-12 2017-04-19 Codexis, Inc. Method of generating an optimized, diverse population of variants
US8504498B2 (en) 2008-02-12 2013-08-06 Codexis, Inc. Method of generating an optimized, diverse population of variants
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
DK3023494T3 (en) 2008-06-13 2019-02-25 Codexis Inc PROCEDURE FOR SYNTHESIS OF POLYNUCLEOTIDE VARIETIES
US8383346B2 (en) 2008-06-13 2013-02-26 Codexis, Inc. Combined automated parallel synthesis of polynucleotide variants
WO2010096369A1 (en) 2009-02-18 2010-08-26 Amicus Therapeutics, Inc. Mouse model for pompe disease and methods of use thereof
ES2690542T3 (es) 2010-02-04 2018-11-21 Biomarin Pharmaceutical Inc. Método para purificar variantes de fenilalanina amoníaco-liasa procariotas
DK2726651T3 (en) 2011-06-28 2019-01-28 Codexis Inc PROTEIN INVARIANT GENERATION BY REGION SHUFFLING
AR087433A1 (es) * 2011-08-08 2014-03-26 Merck Sharp & Dohme Analogos de insulina n-glicosilados
EP2825647A4 (en) 2012-03-15 2015-10-14 Codexis Inc METHODS OF GENE REARRANGING
US9665694B2 (en) 2013-01-31 2017-05-30 Codexis, Inc. Methods, systems, and software for identifying bio-molecules with interacting components
BR112016006284B1 (pt) 2013-09-27 2022-07-26 Codexis, Inc Método implementado por computador, produto de programa de computador, e, sistema de computador
RU2016116253A (ru) 2013-09-27 2017-11-01 Кодексис, Инк. Автоматизированный скрининг вариантов фермента
TW201618809A (zh) * 2014-06-13 2016-06-01 維理恩治療公司 用於治療肝醣儲積症及肝醣代謝病症之方法及組合物
MA41022A (fr) * 2014-11-24 2017-10-03 Shire Human Genetic Therapies Ciblage lysosomial et utilisations correspondantes
LT3237621T (lt) * 2014-12-22 2023-09-25 Codexis, Inc. Žmogaus alfa-galaktozidazės variantai
KR20250007693A (ko) 2015-12-30 2025-01-14 아미쿠스 세라퓨틱스, 인코포레이티드 폼페병 치료용의 강화된 산 알파-글루코시다제
EP3293203A1 (en) * 2016-09-12 2018-03-14 Genethon Acid-alpha glucosidase variants and uses thereof
WO2019201855A1 (en) * 2018-04-16 2019-10-24 Swedish Orphan Biovitrum Ab (Publ) Lysosomal fusion protein
MY207355A (en) 2018-05-16 2025-02-21 Spark Therapeutics Inc Codon-optimized acid lpha-glucosidase expression cassettes and methods of using same
JP2023507575A (ja) 2019-12-20 2023-02-24 コデクシス, インコーポレイテッド 操作された酸性アルファ-グルコシダーゼバリアント
EP4735591A2 (en) 2023-06-30 2026-05-06 Crosswalk Therapeutics, Inc. Engineered acid alpha-glucosidase variants

Similar Documents

Publication Publication Date Title
JP2023507575A5 (https=)
JP7362819B2 (ja) 安定化された可溶性融合前rsv fタンパク質
JP2020528743A5 (https=)
JP2008507298A5 (https=)
JP2010525806A5 (https=)
JP2024180560A5 (https=)
EP2910632B1 (en) Highly functional enzyme having modified substrate specificity of human beta-hexosaminidase b and exhibiting protease resistance
JP2024541466A5 (https=)
JP2008514203A5 (https=)
JP2023512683A5 (https=)
US20250269009A1 (en) Vaccine composition for novel coronavirus infection
JP2025121900A5 (https=)
JP7554359B2 (ja) グルタミン酸-システインリガーゼ変異体及びそれを用いたグルタチオン生産方法
ES2742382T3 (es) Beta-hexosil-transferasas y usos de las mismas
BRPI0914846A2 (pt) novas proteínas de fusão, e sua aplicação na preparação de vacinas contra a hepatite c
JP2022515742A5 (https=)
JP2023539632A5 (https=)
JP2023526655A (ja) ヒトミルクオリゴ糖を産生するための組成物及び方法
JP2023544408A5 (https=)
CN103667329A (zh) 一种高效制备重组人碱性成纤维细胞生长因子的方法
CN102190720A (zh) 一种人胰高血糖素样肽-2(1-35肽)类似物制备方法
AU777860B2 (en) Nitroreductase enzymes
JP7657332B2 (ja) スーパーオキシドディスムターゼ1変異体及びそれを用いたグルタチオン又はその誘導体の生産方法
JP2006501166A5 (https=)
JP2010539964A5 (https=)