JP2023126245A5 - - Google Patents
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- Publication number
- JP2023126245A5 JP2023126245A5 JP2023101681A JP2023101681A JP2023126245A5 JP 2023126245 A5 JP2023126245 A5 JP 2023126245A5 JP 2023101681 A JP2023101681 A JP 2023101681A JP 2023101681 A JP2023101681 A JP 2023101681A JP 2023126245 A5 JP2023126245 A5 JP 2023126245A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- group
- fibrosis
- independently selected
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762535611P | 2017-07-21 | 2017-07-21 | |
| US62/535,611 | 2017-07-21 | ||
| PCT/US2018/043335 WO2019018855A1 (en) | 2017-07-21 | 2018-07-23 | ALPHA PROPELLER PROTEIN KINASE INHIBITORS ("COILED-COIL") ASSOCIATED WITH RHO |
| JP2020502709A JP7383598B2 (ja) | 2017-07-21 | 2018-07-23 | Ｒｈｏ関連コイルドコイル含有プロテインキナーゼの阻害剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502709A Division JP7383598B2 (ja) | 2017-07-21 | 2018-07-23 | Ｒｈｏ関連コイルドコイル含有プロテインキナーゼの阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023126245A JP2023126245A (ja) | 2023-09-07 |
| JP2023126245A5 true JP2023126245A5 (enExample) | 2024-03-12 |
| JP7778745B2 JP7778745B2 (ja) | 2025-12-02 |
Family
ID=65015613
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502709A Active JP7383598B2 (ja) | 2017-07-21 | 2018-07-23 | Ｒｈｏ関連コイルドコイル含有プロテインキナーゼの阻害剤 |
| JP2023101681A Active JP7778745B2 (ja) | 2017-07-21 | 2023-06-21 | Ｒｈｏ関連コイルドコイル含有プロテインキナーゼの阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502709A Active JP7383598B2 (ja) | 2017-07-21 | 2018-07-23 | Ｒｈｏ関連コイルドコイル含有プロテインキナーゼの阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11479533B2 (enExample) |
| EP (1) | EP3654970A4 (enExample) |
| JP (2) | JP7383598B2 (enExample) |
| CN (1) | CN111050766A (enExample) |
| CA (1) | CA3070115A1 (enExample) |
| EA (1) | EA202090306A1 (enExample) |
| WO (1) | WO2019018855A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3752497T1 (sl) * | 2018-02-16 | 2024-10-30 | Constellation Pharmaceuticals, Inc. | Zaviralci P300/CBP HAT |
| TWI777325B (zh) * | 2019-12-31 | 2022-09-11 | 財團法人工業技術研究院 | β-胺基酸衍生物、含其之激酶抑制劑與醫藥組成物以及其用途 |
| CN111707832B (zh) * | 2020-07-16 | 2023-08-15 | 首都医科大学附属北京朝阳医院 | Rock激酶活性在辅助诊断肾损害中的应用 |
| CN111707830B (zh) * | 2020-07-16 | 2023-08-15 | 首都医科大学附属北京朝阳医院 | Rock激酶活性在辅助诊断肺损害中的应用 |
| EP4440566A4 (en) * | 2021-11-29 | 2025-10-01 | Woolsey Pharmaceuticals Inc | METHODS FOR TREATING AGITATION AND OTHER BEHAVIORAL SYMPTOMS ASSOCIATED WITH DEMENTIA |
| WO2024075838A1 (ja) * | 2022-10-07 | 2024-04-11 | 国立研究開発法人理化学研究所 | 肺線維症モデル、及び、肺線維症の予防又は治療剤のスクリーニング方法 |
| WO2025017500A1 (en) * | 2023-07-17 | 2025-01-23 | Graviton Bioscience Bv | Formulations of rock2 inhibitors for cns disorders |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7294624B2 (en) | 2001-12-20 | 2007-11-13 | Bristol Myers Squibb Company | Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases |
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| CA2499128C (en) * | 2002-09-25 | 2012-07-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| US8211919B2 (en) * | 2005-09-02 | 2012-07-03 | Astellas Pharma Inc. | Amide derivatives as rock inhibitors |
| CA2709879A1 (en) * | 2007-12-19 | 2009-06-25 | The Scripps Research Institute | Anilides and analogs as rho kinase inhibitors |
| CN105102448B (zh) * | 2013-02-28 | 2018-03-06 | 百时美施贵宝公司 | 作为rock1和rock2抑制剂的苯基吡唑衍生物 |
| WO2015006100A1 (en) * | 2013-07-08 | 2015-01-15 | Bristol-Myers Squibb Company | Aryl amide kinase inhibitors |
| US9617214B2 (en) * | 2013-11-08 | 2017-04-11 | The Translational Genomics Research Institute | Compounds for cognitive enhancement and methods of use thereof |
| US10035777B2 (en) * | 2014-08-05 | 2018-07-31 | Bristol-Myers Squibb Company | Heterocyclic kinase inhibitors |
| JP2020528415A (ja) * | 2017-07-21 | 2020-09-24 | カドモン コーポレイション，リミティド ライアビリティ カンパニー | Ｒｈｏ関連コイルドコイル含有プロテインキナーゼの阻害剤 |
| JP7399848B2 (ja) * | 2017-09-01 | 2023-12-18 | カドモン コーポレイション，リミティド ライアビリティ カンパニー | Ｒｈｏ関連コイルドコイル含有プロテインキナーゼの阻害剤 |
-
2018
- 2018-07-23 JP JP2020502709A patent/JP7383598B2/ja active Active
- 2018-07-23 EP EP18834641.5A patent/EP3654970A4/en active Pending
- 2018-07-23 CA CA3070115A patent/CA3070115A1/en active Pending
- 2018-07-23 EA EA202090306A patent/EA202090306A1/ru unknown
- 2018-07-23 CN CN201880049759.5A patent/CN111050766A/zh active Pending
- 2018-07-23 US US16/632,662 patent/US11479533B2/en active Active
- 2018-07-23 WO PCT/US2018/043335 patent/WO2019018855A1/en not_active Ceased
-
2023
- 2023-06-21 JP JP2023101681A patent/JP7778745B2/ja active Active
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