JP2023104963A5 - - Google Patents
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- Publication number
- JP2023104963A5 JP2023104963A5 JP2023079234A JP2023079234A JP2023104963A5 JP 2023104963 A5 JP2023104963 A5 JP 2023104963A5 JP 2023079234 A JP2023079234 A JP 2023079234A JP 2023079234 A JP2023079234 A JP 2023079234A JP 2023104963 A5 JP2023104963 A5 JP 2023104963A5
- Authority
- JP
- Japan
- Prior art keywords
- excipient
- isomers
- formulation according
- apocynin
- paeonol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 claims 17
- DFYRUELUNQRZTB-UHFFFAOYSA-N apocynin Chemical compound COC1=CC(C(C)=O)=CC=C1O DFYRUELUNQRZTB-UHFFFAOYSA-N 0.000 claims 17
- 239000000546 pharmaceutical excipient Substances 0.000 claims 13
- 238000009472 formulation Methods 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 229930188866 apocynin Natural products 0.000 claims 7
- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 claims 7
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000012669 liquid formulation Substances 0.000 claims 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 4
- 125000003827 glycol group Chemical group 0.000 claims 4
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 239000000374 eutectic mixture Substances 0.000 claims 2
- 150000002334 glycols Chemical class 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims 2
- 150000005846 sugar alcohols Polymers 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025022755A JP2025065531A (ja) | 2017-11-23 | 2025-02-14 | ペオノール及びアポシニンを含む液体製剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1719464.8 | 2017-11-23 | ||
| GB1719464.8A GB2568698A (en) | 2017-11-23 | 2017-11-23 | Formulation |
| JP2020545869A JP7314157B2 (ja) | 2017-11-23 | 2018-11-22 | ペオノール及びアポシニンを含む液体製剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020545869A Division JP7314157B2 (ja) | 2017-11-23 | 2018-11-22 | ペオノール及びアポシニンを含む液体製剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025022755A Division JP2025065531A (ja) | 2017-11-23 | 2025-02-14 | ペオノール及びアポシニンを含む液体製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023104963A JP2023104963A (ja) | 2023-07-28 |
| JP2023104963A5 true JP2023104963A5 (cg-RX-API-DMAC7.html) | 2024-01-31 |
Family
ID=60950758
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020545869A Active JP7314157B2 (ja) | 2017-11-23 | 2018-11-22 | ペオノール及びアポシニンを含む液体製剤 |
| JP2023079234A Pending JP2023104963A (ja) | 2017-11-23 | 2023-05-12 | ペオノール及びアポシニンを含む液体製剤 |
| JP2025022755A Pending JP2025065531A (ja) | 2017-11-23 | 2025-02-14 | ペオノール及びアポシニンを含む液体製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020545869A Active JP7314157B2 (ja) | 2017-11-23 | 2018-11-22 | ペオノール及びアポシニンを含む液体製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025022755A Pending JP2025065531A (ja) | 2017-11-23 | 2025-02-14 | ペオノール及びアポシニンを含む液体製剤 |
Country Status (21)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2568698A (en) * | 2017-11-23 | 2019-05-29 | Akl Res & Development Ltd | Formulation |
| GB202218160D0 (en) * | 2022-12-02 | 2023-01-18 | Akl Res & Development Ltd | Formulation |
| CN119033608B (zh) * | 2024-11-01 | 2025-03-25 | 深圳杉海创新技术有限公司 | 一种具有抑菌作用的低共熔溶剂、微脂囊及其制备方法与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR920700613A (ko) * | 1989-05-16 | 1992-08-10 | 지구르트 퓌터 | 약제제 |
| CN100544708C (zh) * | 2004-08-18 | 2009-09-30 | 上海佰加壹医药有限公司 | 一种丹皮酚软胶囊及其制备方法 |
| GB2424833B (en) * | 2005-04-08 | 2008-12-10 | Nicholas John Larkins | Anti-inflammatory formulation comprising apocyanin and paeonol |
| GB2463080A (en) * | 2008-09-02 | 2010-03-03 | Nicholas John Larkins | Pharmaceutical preparation |
| GB201115757D0 (en) * | 2011-09-12 | 2011-10-26 | Akl Inflammatory Ltd | Formulation for the treatment of benign prostate hyperplasia |
| GB201416909D0 (en) * | 2014-09-25 | 2014-11-12 | Prosonix Ltd | Method of forming concentrated solution |
| GB2547241A (en) * | 2016-02-11 | 2017-08-16 | Akl Res & Dev Ltd | Anti-inflammatory formulation |
| GB2568698A (en) * | 2017-11-23 | 2019-05-29 | Akl Res & Development Ltd | Formulation |
-
2017
- 2017-11-23 GB GB1719464.8A patent/GB2568698A/en not_active Withdrawn
-
2018
- 2018-11-22 EP EP21209333.0A patent/EP4019005A1/en active Pending
- 2018-11-22 HR HRP20220303TT patent/HRP20220303T1/hr unknown
- 2018-11-22 HU HUE18810956A patent/HUE057595T2/hu unknown
- 2018-11-22 ES ES18810956T patent/ES2906761T3/es active Active
- 2018-11-22 JP JP2020545869A patent/JP7314157B2/ja active Active
- 2018-11-22 KR KR1020257001687A patent/KR20250013306A/ko active Pending
- 2018-11-22 MX MX2020005313A patent/MX393836B/es unknown
- 2018-11-22 LT LTEPPCT/EP2018/082178T patent/LT3713546T/lt unknown
- 2018-11-22 CN CN201880075175.5A patent/CN111372572B/zh active Active
- 2018-11-22 PL PL18810956T patent/PL3713546T3/pl unknown
- 2018-11-22 WO PCT/EP2018/082178 patent/WO2019101842A1/en not_active Ceased
- 2018-11-22 RS RS20220135A patent/RS62923B1/sr unknown
- 2018-11-22 EP EP18810956.5A patent/EP3713546B1/en active Active
- 2018-11-22 US US16/765,627 patent/US11701325B2/en active Active
- 2018-11-22 CA CA3082945A patent/CA3082945A1/en active Pending
- 2018-11-22 PT PT188109565T patent/PT3713546T/pt unknown
- 2018-11-22 SI SI201830590T patent/SI3713546T1/sl unknown
- 2018-11-22 KR KR1020207018001A patent/KR102758107B1/ko active Active
- 2018-11-22 SM SM20220101T patent/SMT202200101T1/it unknown
- 2018-11-22 CN CN202310468972.2A patent/CN116999417A/zh active Pending
- 2018-11-22 DK DK18810956.5T patent/DK3713546T3/da active
- 2018-11-22 AU AU2018371165A patent/AU2018371165B2/en active Active
-
2020
- 2020-07-13 MX MX2022008551A patent/MX2022008551A/es unknown
-
2022
- 2022-02-10 CY CY20221100119T patent/CY1124986T1/el unknown
-
2023
- 2023-05-12 JP JP2023079234A patent/JP2023104963A/ja active Pending
- 2023-06-01 US US18/327,202 patent/US20230330017A1/en active Pending
-
2024
- 2024-05-27 AU AU2024203514A patent/AU2024203514B2/en active Active
-
2025
- 2025-02-14 JP JP2025022755A patent/JP2025065531A/ja active Pending
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