CN111372572B - 包含丹皮酚和罗布麻宁的液体制剂 - Google Patents

包含丹皮酚和罗布麻宁的液体制剂 Download PDF

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Publication number
CN111372572B
CN111372572B CN201880075175.5A CN201880075175A CN111372572B CN 111372572 B CN111372572 B CN 111372572B CN 201880075175 A CN201880075175 A CN 201880075175A CN 111372572 B CN111372572 B CN 111372572B
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apocynum
paeonol
formulation
liquid
excipient
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Chinese (zh)
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CN111372572A (zh
Inventor
尼古拉斯·约翰·拉金斯
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Akl Research And Development Co ltd
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Akl Research And Development Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/68—Plantaginaceae (Plantain Family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CN201880075175.5A 2017-11-23 2018-11-22 包含丹皮酚和罗布麻宁的液体制剂 Active CN111372572B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310468972.2A CN116999417A (zh) 2017-11-23 2018-11-22 包含丹皮酚和罗布麻宁的液体制剂

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1719464.8 2017-11-23
GB1719464.8A GB2568698A (en) 2017-11-23 2017-11-23 Formulation
PCT/EP2018/082178 WO2019101842A1 (en) 2017-11-23 2018-11-22 Liquid formulation comprising paeonol and apocynin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202310468972.2A Division CN116999417A (zh) 2017-11-23 2018-11-22 包含丹皮酚和罗布麻宁的液体制剂

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Publication Number Publication Date
CN111372572A CN111372572A (zh) 2020-07-03
CN111372572B true CN111372572B (zh) 2023-08-29

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CN202310468972.2A Pending CN116999417A (zh) 2017-11-23 2018-11-22 包含丹皮酚和罗布麻宁的液体制剂

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Country Link
US (2) US11701325B2 (cg-RX-API-DMAC7.html)
EP (2) EP4019005A1 (cg-RX-API-DMAC7.html)
JP (3) JP7314157B2 (cg-RX-API-DMAC7.html)
KR (2) KR20250013306A (cg-RX-API-DMAC7.html)
CN (2) CN111372572B (cg-RX-API-DMAC7.html)
AU (2) AU2018371165B2 (cg-RX-API-DMAC7.html)
CA (1) CA3082945A1 (cg-RX-API-DMAC7.html)
CY (1) CY1124986T1 (cg-RX-API-DMAC7.html)
DK (1) DK3713546T3 (cg-RX-API-DMAC7.html)
ES (1) ES2906761T3 (cg-RX-API-DMAC7.html)
GB (1) GB2568698A (cg-RX-API-DMAC7.html)
HR (1) HRP20220303T1 (cg-RX-API-DMAC7.html)
HU (1) HUE057595T2 (cg-RX-API-DMAC7.html)
LT (1) LT3713546T (cg-RX-API-DMAC7.html)
MX (2) MX393836B (cg-RX-API-DMAC7.html)
PL (1) PL3713546T3 (cg-RX-API-DMAC7.html)
PT (1) PT3713546T (cg-RX-API-DMAC7.html)
RS (1) RS62923B1 (cg-RX-API-DMAC7.html)
SI (1) SI3713546T1 (cg-RX-API-DMAC7.html)
SM (1) SMT202200101T1 (cg-RX-API-DMAC7.html)
WO (1) WO2019101842A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2568698A (en) * 2017-11-23 2019-05-29 Akl Res & Development Ltd Formulation
GB202218160D0 (en) * 2022-12-02 2023-01-18 Akl Res & Development Ltd Formulation
CN119033608B (zh) * 2024-11-01 2025-03-25 深圳杉海创新技术有限公司 一种具有抑菌作用的低共熔溶剂、微脂囊及其制备方法与应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1053010A (zh) * 1989-05-16 1991-07-17 梅迪斯化学药物工厂普特两合股份公司 药物制剂
GB0507208D0 (en) * 2005-04-08 2005-05-18 Larkins Nicholas J Anti-inflammatory formulation
CN1736368A (zh) * 2004-08-18 2006-02-22 上海佰加壹医药有限公司 一种丹皮酚软胶囊及其制备方法和用途
WO2013037843A1 (en) * 2011-09-12 2013-03-21 Akl Inflammatory Limited Formulation for the treatment of benign prostate hyperplasia
WO2017137767A1 (en) * 2016-02-11 2017-08-17 Akl Research & Development Ltd Anti-neurodegenerative disease formulation containing apocynin and paeonol
US20170296510A1 (en) * 2014-09-25 2017-10-19 Prosonix Limited Method of forming concentrated solution

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2463080A (en) * 2008-09-02 2010-03-03 Nicholas John Larkins Pharmaceutical preparation
GB2568698A (en) * 2017-11-23 2019-05-29 Akl Res & Development Ltd Formulation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1053010A (zh) * 1989-05-16 1991-07-17 梅迪斯化学药物工厂普特两合股份公司 药物制剂
CN1736368A (zh) * 2004-08-18 2006-02-22 上海佰加壹医药有限公司 一种丹皮酚软胶囊及其制备方法和用途
GB0507208D0 (en) * 2005-04-08 2005-05-18 Larkins Nicholas J Anti-inflammatory formulation
WO2013037843A1 (en) * 2011-09-12 2013-03-21 Akl Inflammatory Limited Formulation for the treatment of benign prostate hyperplasia
US20170296510A1 (en) * 2014-09-25 2017-10-19 Prosonix Limited Method of forming concentrated solution
WO2017137767A1 (en) * 2016-02-11 2017-08-17 Akl Research & Development Ltd Anti-neurodegenerative disease formulation containing apocynin and paeonol

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
丹皮酚的主要药理活性研究进展;孙言才等;《中成药》;第26卷(第7期);第579-583页 *

Also Published As

Publication number Publication date
NZ764238A (en) 2025-12-19
HRP20220303T1 (hr) 2022-05-13
CN116999417A (zh) 2023-11-07
CY1124986T1 (el) 2023-01-05
PT3713546T (pt) 2022-02-02
GB2568698A (en) 2019-05-29
MX2020005313A (es) 2020-08-17
GB201719464D0 (en) 2018-01-10
US20200297628A1 (en) 2020-09-24
LT3713546T (lt) 2022-03-10
JP2023104963A (ja) 2023-07-28
EP3713546B1 (en) 2021-12-08
KR20200090858A (ko) 2020-07-29
JP2025065531A (ja) 2025-04-17
CA3082945A1 (en) 2019-05-31
AU2018371165B2 (en) 2024-02-29
ES2906761T3 (es) 2022-04-20
US20230330017A1 (en) 2023-10-19
CN111372572A (zh) 2020-07-03
MX2022008551A (es) 2022-08-10
JP2021504461A (ja) 2021-02-15
AU2024203514B2 (en) 2026-03-19
HUE057595T2 (hu) 2022-05-28
WO2019101842A1 (en) 2019-05-31
PL3713546T3 (pl) 2022-05-02
AU2024203514A1 (en) 2024-06-20
US11701325B2 (en) 2023-07-18
RS62923B1 (sr) 2022-03-31
SI3713546T1 (sl) 2022-04-29
SMT202200101T1 (it) 2022-03-21
EP3713546A1 (en) 2020-09-30
AU2018371165A1 (en) 2020-05-21
EP4019005A1 (en) 2022-06-29
KR102758107B1 (ko) 2025-01-20
DK3713546T3 (da) 2022-01-31
KR20250013306A (ko) 2025-01-31
JP7314157B2 (ja) 2023-07-25
MX393836B (es) 2025-03-24

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