JP2023085437A5 - - Google Patents

Info

Publication number

JP2023085437A5

JP2023085437A5 JP2023060872A JP2023060872A JP2023085437A5 JP 2023085437 A5 JP2023085437 A5 JP 2023085437A5 JP 2023060872 A JP2023060872 A JP 2023060872A JP 2023060872 A JP2023060872 A JP 2023060872A JP 2023085437 A5 JP2023085437 A5 JP 2023085437A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

tissue

hdl

derived nanoparticles

composition according

Prior art date

2023-04-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 25
• 210000001519 tissue Anatomy 0.000 claims 14
• 102000015779 HDL Lipoproteins Human genes 0.000 claims 9
• 108010010234 HDL Lipoproteins Proteins 0.000 claims 9
• 239000002105 nanoparticle Substances 0.000 claims 8
• 210000000056 organ Anatomy 0.000 claims 6
• VXUOFDJKYGDUJI-OAQYLSRUSA-N 1-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP([O-])(=O)OCC[N+](C)(C)C VXUOFDJKYGDUJI-OAQYLSRUSA-N 0.000 claims 4
• 230000000735 allogeneic effect Effects 0.000 claims 4
• 238000002054 transplantation Methods 0.000 claims 4
• GZDFHIJNHHMENY-UHFFFAOYSA-N Dimethyl dicarbonate Chemical compound COC(=O)OC(=O)OC GZDFHIJNHHMENY-UHFFFAOYSA-N 0.000 claims 3
• 239000003018 immunosuppressive agent Substances 0.000 claims 3
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 3
• 229960002930 sirolimus Drugs 0.000 claims 3
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 3
• 102000005666 Apolipoprotein A-I Human genes 0.000 claims 2
• 108010059886 Apolipoprotein A-I Proteins 0.000 claims 2
• 210000000988 bone and bone Anatomy 0.000 claims 2
• 239000002775 capsule Substances 0.000 claims 2
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
• 229960003444 immunosuppressant agent Drugs 0.000 claims 2
• CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 claims 1
• 229930105110 Cyclosporin A Natural products 0.000 claims 1
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical group CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
• 108010036949 Cyclosporine Proteins 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
• 239000002260 anti-inflammatory agent Substances 0.000 claims 1
• 235000012000 cholesterol Nutrition 0.000 claims 1
• 229960001265 ciclosporin Drugs 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 210000005003 heart tissue Anatomy 0.000 claims 1
• 230000001506 immunosuppresive effect Effects 0.000 claims 1
• 230000001861 immunosuppressant effect Effects 0.000 claims 1
• 229940125721 immunosuppressive agent Drugs 0.000 claims 1
• 239000007943 implant Substances 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 230000000968 intestinal effect Effects 0.000 claims 1
• 238000001361 intraarterial administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 210000005228 liver tissue Anatomy 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 210000001672 ovary Anatomy 0.000 claims 1
• 210000004923 pancreatic tissue Anatomy 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000002035 prolonged effect Effects 0.000 claims 1
• 210000005084 renal tissue Anatomy 0.000 claims 1
• 230000001850 reproductive effect Effects 0.000 claims 1
• 230000002207 retinal effect Effects 0.000 claims 1
• 230000004083 survival effect Effects 0.000 claims 1
• 210000002435 tendon Anatomy 0.000 claims 1
• 230000002792 vascular Effects 0.000 claims 1