JPS5528933A - Muramyldipeptide dimer - Google Patents

Muramyldipeptide dimer

Info

Publication number
JPS5528933A
JPS5528933A JP10163278A JP10163278A JPS5528933A JP S5528933 A JPS5528933 A JP S5528933A JP 10163278 A JP10163278 A JP 10163278A JP 10163278 A JP10163278 A JP 10163278A JP S5528933 A JPS5528933 A JP S5528933A
Authority
JP
Japan
Prior art keywords
formula
compound
isoglutaminyl
acetylmuramyl
alanyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10163278A
Other languages
Japanese (ja)
Inventor
Yuichi Yamamura
Tetsuo Shiba
Ichiro Azuma
Shoichi Kusumoto
Osamu Nagase
Tsuneo Nichima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP10163278A priority Critical patent/JPS5528933A/en
Publication of JPS5528933A publication Critical patent/JPS5528933A/en
Pending legal-status Critical Current

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  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A muramyldipeptide derivative of formula I: (X is amino acid, e.g. L-alanin, L-serine, or L-valine; n is an integer 1W6; R1 is H, lower alkyl, carboxyl group, etc.; A1 and A2 are intermediate to higher mycoloyl or 20W60C synthetic higher fatty acid residues which may be branched, one of them may be H).
EXAMPLE: Nα-(N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-Nξ-(6-O-mycomycoloyl- N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-L-lysine.
USE: Medicines capable of preparing uniform suspensions with a phosphoric acid buffer physiological salt solution having improved lipophilic nature, and tumor cell damage activity (closely related to the antitumor activity).
PROCESS: A compound of formula II is condensed with a compound of formula III by the ordinary peptide synthesis to give the objective compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP10163278A 1978-08-21 1978-08-21 Muramyldipeptide dimer Pending JPS5528933A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10163278A JPS5528933A (en) 1978-08-21 1978-08-21 Muramyldipeptide dimer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10163278A JPS5528933A (en) 1978-08-21 1978-08-21 Muramyldipeptide dimer

Publications (1)

Publication Number Publication Date
JPS5528933A true JPS5528933A (en) 1980-02-29

Family

ID=14305764

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10163278A Pending JPS5528933A (en) 1978-08-21 1978-08-21 Muramyldipeptide dimer

Country Status (1)

Country Link
JP (1) JPS5528933A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59172497A (en) * 1983-03-22 1984-09-29 Dai Ichi Seiyaku Co Ltd Novel muramyl peptide derivative
JPS61287525A (en) * 1985-06-12 1986-12-17 松下電工株式会社 Vacuum packaging machine
JP2009080118A (en) * 1996-10-10 2009-04-16 Probe Internatl Composition and method for treating viral infection
US11859021B2 (en) 2021-03-19 2024-01-02 Icahn School Of Medicine At Mount Sinai Compounds for regulating trained immunity, and their methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55391A (en) * 1978-06-05 1980-01-05 Anvar Oligomers of muramyllpeptide type compound and drug containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55391A (en) * 1978-06-05 1980-01-05 Anvar Oligomers of muramyllpeptide type compound and drug containing them

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59172497A (en) * 1983-03-22 1984-09-29 Dai Ichi Seiyaku Co Ltd Novel muramyl peptide derivative
JPS61287525A (en) * 1985-06-12 1986-12-17 松下電工株式会社 Vacuum packaging machine
JP2009080118A (en) * 1996-10-10 2009-04-16 Probe Internatl Composition and method for treating viral infection
US11859021B2 (en) 2021-03-19 2024-01-02 Icahn School Of Medicine At Mount Sinai Compounds for regulating trained immunity, and their methods of use

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