JPS5528933A - Muramyldipeptide dimer - Google Patents
Muramyldipeptide dimerInfo
- Publication number
- JPS5528933A JPS5528933A JP10163278A JP10163278A JPS5528933A JP S5528933 A JPS5528933 A JP S5528933A JP 10163278 A JP10163278 A JP 10163278A JP 10163278 A JP10163278 A JP 10163278A JP S5528933 A JPS5528933 A JP S5528933A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- isoglutaminyl
- acetylmuramyl
- alanyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A muramyldipeptide derivative of formula I: (X is amino acid, e.g. L-alanin, L-serine, or L-valine; n is an integer 1W6; R1 is H, lower alkyl, carboxyl group, etc.; A1 and A2 are intermediate to higher mycoloyl or 20W60C synthetic higher fatty acid residues which may be branched, one of them may be H).
EXAMPLE: Nα-(N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-Nξ-(6-O-mycomycoloyl- N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-L-lysine.
USE: Medicines capable of preparing uniform suspensions with a phosphoric acid buffer physiological salt solution having improved lipophilic nature, and tumor cell damage activity (closely related to the antitumor activity).
PROCESS: A compound of formula II is condensed with a compound of formula III by the ordinary peptide synthesis to give the objective compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10163278A JPS5528933A (en) | 1978-08-21 | 1978-08-21 | Muramyldipeptide dimer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10163278A JPS5528933A (en) | 1978-08-21 | 1978-08-21 | Muramyldipeptide dimer |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5528933A true JPS5528933A (en) | 1980-02-29 |
Family
ID=14305764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10163278A Pending JPS5528933A (en) | 1978-08-21 | 1978-08-21 | Muramyldipeptide dimer |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5528933A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59172497A (en) * | 1983-03-22 | 1984-09-29 | Dai Ichi Seiyaku Co Ltd | Novel muramyl peptide derivative |
JPS61287525A (en) * | 1985-06-12 | 1986-12-17 | 松下電工株式会社 | Vacuum packaging machine |
JP2009080118A (en) * | 1996-10-10 | 2009-04-16 | Probe Internatl | Composition and method for treating viral infection |
US11859021B2 (en) | 2021-03-19 | 2024-01-02 | Icahn School Of Medicine At Mount Sinai | Compounds for regulating trained immunity, and their methods of use |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55391A (en) * | 1978-06-05 | 1980-01-05 | Anvar | Oligomers of muramyllpeptide type compound and drug containing them |
-
1978
- 1978-08-21 JP JP10163278A patent/JPS5528933A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55391A (en) * | 1978-06-05 | 1980-01-05 | Anvar | Oligomers of muramyllpeptide type compound and drug containing them |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59172497A (en) * | 1983-03-22 | 1984-09-29 | Dai Ichi Seiyaku Co Ltd | Novel muramyl peptide derivative |
JPS61287525A (en) * | 1985-06-12 | 1986-12-17 | 松下電工株式会社 | Vacuum packaging machine |
JP2009080118A (en) * | 1996-10-10 | 2009-04-16 | Probe Internatl | Composition and method for treating viral infection |
US11859021B2 (en) | 2021-03-19 | 2024-01-02 | Icahn School Of Medicine At Mount Sinai | Compounds for regulating trained immunity, and their methods of use |
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