JP2023081949A5 - - Google Patents
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- JP2023081949A5 JP2023081949A5 JP2023032695A JP2023032695A JP2023081949A5 JP 2023081949 A5 JP2023081949 A5 JP 2023081949A5 JP 2023032695 A JP2023032695 A JP 2023032695A JP 2023032695 A JP2023032695 A JP 2023032695A JP 2023081949 A5 JP2023081949 A5 JP 2023081949A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- amino acid
- tcr
- acid residues
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108091008874 T cell receptors Proteins 0.000 claims 40
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 40
- 125000000539 amino acid group Chemical group 0.000 claims 30
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 2
- 101000795989 Homo sapiens T cell receptor alpha variable 10 Proteins 0.000 claims 1
- 101000939745 Homo sapiens T cell receptor beta variable 24-1 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100031333 T cell receptor alpha variable 10 Human genes 0.000 claims 1
- 102100029656 T cell receptor beta variable 24-1 Human genes 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000833 heterodimer Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1606177.2 | 2016-04-08 | ||
| GB201606177 | 2016-04-08 | ||
| PCT/EP2017/058580 WO2017174824A1 (en) | 2016-04-08 | 2017-04-10 | T cell receptors |
| JP2018552872A JP7240176B2 (ja) | 2016-04-08 | 2017-04-10 | Ｔ細胞受容体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018552872A Division JP7240176B2 (ja) | 2016-04-08 | 2017-04-10 | Ｔ細胞受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023081949A JP2023081949A (ja) | 2023-06-13 |
| JP2023081949A5 true JP2023081949A5 (https=) | 2023-10-16 |
| JP7577149B2 JP7577149B2 (ja) | 2024-11-01 |
Family
ID=58701592
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018552872A Active JP7240176B2 (ja) | 2016-04-08 | 2017-04-10 | Ｔ細胞受容体 |
| JP2023032695A Active JP7577149B2 (ja) | 2016-04-08 | 2023-03-03 | Ｔ細胞受容体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018552872A Active JP7240176B2 (ja) | 2016-04-08 | 2017-04-10 | Ｔ細胞受容体 |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US11286289B2 (https=) |
| EP (2) | EP3440106B1 (https=) |
| JP (2) | JP7240176B2 (https=) |
| KR (2) | KR102747867B1 (https=) |
| CN (2) | CN116217703A (https=) |
| AU (2) | AU2017248122B2 (https=) |
| BR (1) | BR112018070625A2 (https=) |
| CA (1) | CA3020058A1 (https=) |
| CY (1) | CY1124664T1 (https=) |
| DK (1) | DK3440106T3 (https=) |
| ES (1) | ES2891321T3 (https=) |
| HR (1) | HRP20211493T1 (https=) |
| HU (1) | HUE056433T2 (https=) |
| IL (1) | IL262128B2 (https=) |
| LT (1) | LT3440106T (https=) |
| MX (2) | MX395611B (https=) |
| PL (1) | PL3440106T3 (https=) |
| PT (1) | PT3440106T (https=) |
| RS (1) | RS62623B1 (https=) |
| RU (1) | RU2018138838A (https=) |
| SG (1) | SG11201808751SA (https=) |
| SI (1) | SI3440106T1 (https=) |
| SM (1) | SMT202100564T1 (https=) |
| WO (1) | WO2017174824A1 (https=) |
| ZA (2) | ZA201806866B (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
| MA49156A (fr) | 2014-12-23 | 2020-03-25 | Immatics Biotechnologies Gmbh | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
| DK3440106T3 (da) | 2016-04-08 | 2021-10-04 | Adaptimmune Ltd | T-cellereceptorer |
| KR20190059874A (ko) * | 2016-04-08 | 2019-05-31 | 어댑티뮨 리미티드 | T 세포 수용체 |
| BR112018070637A2 (pt) * | 2016-04-08 | 2019-02-05 | Adaptimmune Ltd | receptores de células t |
| WO2019069125A1 (en) | 2017-10-06 | 2019-04-11 | Oslo Universitetssykehus Hf | CHIMERIC ANTIGEN RECEPTORS |
| CN109777778B (zh) * | 2017-11-14 | 2023-07-18 | 中国科学院广州生物医药与健康研究院 | 一种基因改造的γδT细胞 |
| GB201803750D0 (en) | 2018-03-08 | 2018-04-25 | Immunocore Ltd | Method |
| GB201819540D0 (en) | 2018-11-30 | 2019-01-16 | Adaptimmune Ltd | T cell modification |
| EP3714941A1 (en) * | 2019-03-27 | 2020-09-30 | Medigene Immunotherapies GmbH | Mage-a4 tcrs |
| CA3139011A1 (en) * | 2019-05-08 | 2020-11-12 | Medigene Immunotherapies Gmbh | Engineered t cells |
| PH12021553152A1 (en) * | 2019-06-18 | 2022-08-15 | Regeneron Pharma | Mage-a4 t cell receptors and methods of use thereof |
| WO2020263830A1 (en) | 2019-06-25 | 2020-12-30 | Gilead Sciences, Inc. | Flt3l-fc fusion proteins and methods of use |
| EP4004049A1 (en) | 2019-07-24 | 2022-06-01 | Regeneron Pharmaceuticals, Inc. | Chimeric antigen receptors with mage-a4 specificity and uses thereof |
| AU2020327671A1 (en) | 2019-08-13 | 2022-03-03 | King's College London | Immunoresponsive cells armoured with spatiotemporally restricted activity of cytokines of the IL-1 superfamily |
| KR20220100963A (ko) | 2019-12-18 | 2022-07-18 | 에프. 호프만-라 로슈 아게 | Hla-a2/mage-a4에 결합하는 항체 |
| WO2021144338A1 (en) * | 2020-01-14 | 2021-07-22 | Adaptimmune Limited | Method of treatment of cancer or tumour |
| TWI890283B (zh) | 2020-02-14 | 2025-07-11 | 美商基利科學股份有限公司 | 結合ccr8之抗體及融合蛋白及其用途 |
| GB202006903D0 (en) * | 2020-05-11 | 2020-06-24 | Adaptimmune Ltd | Modified iPSCs |
| CA3183756A1 (en) | 2020-05-19 | 2021-11-25 | Amgen Inc. | Mageb2 binding constructs |
| TW202406932A (zh) | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| MX2023010541A (es) * | 2021-03-09 | 2023-11-24 | Cdr Life Ag | Proteinas de union al antigeno del peptido del mhc mage-a4. |
| US12435444B2 (en) | 2021-03-09 | 2025-10-07 | Cdr-Life Ag | Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same |
| WO2022245671A1 (en) | 2021-05-18 | 2022-11-24 | Gilead Sciences, Inc. | Methods of using flt3l-fc fusion proteins |
| EP4091627A1 (en) | 2021-05-21 | 2022-11-23 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Tcr constructs specific for magea4-derived epitopes |
| EP4422651A4 (en) * | 2021-10-25 | 2025-12-17 | Univ Texas | PEPTIDES AND MANIPULATED T-CELL RECEPTORS FOR TARGETTING THE MAGE-A4 ANTIGEN AND METHOD FOR USE |
| AU2022375782B2 (en) | 2021-10-28 | 2026-02-26 | Gilead Sciences, Inc. | Pyridizin-3(2h)-one derivatives |
| JP7787991B2 (ja) | 2021-10-29 | 2025-12-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｃｄ７３化合物 |
| US12122764B2 (en) | 2021-12-22 | 2024-10-22 | Gilead Sciences, Inc. | IKAROS zinc finger family degraders and uses thereof |
| KR20240123836A (ko) | 2021-12-22 | 2024-08-14 | 길리애드 사이언시즈, 인코포레이티드 | 이카로스 아연 핑거 패밀리 분해제 및 이의 용도 |
| TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Ｐａｒｐ７抑制劑 |
| WO2023178181A1 (en) | 2022-03-17 | 2023-09-21 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| CN116836261A (zh) * | 2022-03-24 | 2023-10-03 | 香雪生命科学技术（广东）有限公司 | 一种识别mage-a4抗原的高亲和力tcr及其序列和应用 |
| GB202205572D0 (en) | 2022-04-14 | 2022-06-01 | Adaptimmune Ltd | Engineered T cells |
| CR20240451A (es) | 2022-04-21 | 2024-12-04 | Gilead Sciences Inc | Compuestos de modulación de kras g12d |
| KR20250028371A (ko) | 2022-07-01 | 2025-02-28 | 길리애드 사이언시즈, 인코포레이티드 | Cd73 화합물 |
| CA3264474A1 (en) | 2022-09-14 | 2024-03-21 | Cdr-Life Ag | MAGE-A4 DOUBLE T LYMPHOCYTE ENGAGEMENT |
| AU2023241306B2 (en) * | 2022-10-05 | 2024-10-03 | Tscan Therapeutics, Inc. | Prame immunogenic peptides, binding proteins recognizing prame immunogenic peptides, and uses thereof |
| EP4598569A1 (en) * | 2022-10-05 | 2025-08-13 | Tscan Therapeutics, Inc. | Magea1 immunogenic peptides, binding proteins recognizing magea1 immunogenic peptides, and uses thereof |
| AU2023409398A1 (en) | 2022-12-22 | 2025-06-05 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| AU2024252725A1 (en) | 2023-04-11 | 2025-11-06 | Gilead Sciences, Inc. | Kras modulating compounds |
| CR20250446A (es) | 2023-04-21 | 2025-12-02 | Gilead Sciences Inc | Inhibidores de prmt5 y usos de los mismos |
| AU2024306338A1 (en) | 2023-06-30 | 2026-01-08 | Gilead Sciences, Inc. | Kras modulating compounds |
| CN121620513A (zh) | 2023-07-26 | 2026-03-06 | 吉利德科学公司 | Parp7抑制剂 |
| KR20260046403A (ko) | 2023-07-26 | 2026-04-07 | 길리애드 사이언시즈, 인코포레이티드 | Parp7 저해제 |
| US20250109147A1 (en) | 2023-09-08 | 2025-04-03 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| US20250101042A1 (en) | 2023-09-08 | 2025-03-27 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| US20250154172A1 (en) | 2023-11-03 | 2025-05-15 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025245003A1 (en) | 2024-05-21 | 2025-11-27 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| US20260098049A1 (en) | 2024-08-12 | 2026-04-09 | Gilead Sciences, Inc. | Kras modulating compounds |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000502079A (ja) * | 1995-12-08 | 2000-02-22 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | アテローム性動脈硬化症の治療のための単環β―ラクタム誘導体 |
| US7521197B2 (en) | 1998-06-05 | 2009-04-21 | Alexis Biotech Limited | Method for producing cytotoxic T-cells |
| WO2000020445A2 (en) | 1998-10-02 | 2000-04-13 | Ludwig Institute For Cancer Research | Tumor antigens and ctl clones isolated by a novel procedure |
| US7157091B1 (en) | 1999-06-18 | 2007-01-02 | Ludwig Institute For Cancer Research | MAGE-A1 peptides presented by HLA class II molecules |
| US6867283B2 (en) | 2001-05-16 | 2005-03-15 | Technion Research & Development Foundation Ltd. | Peptides capable of binding to MHC molecules, cells presenting such peptides, and pharmaceutical compositions comprising such peptides and/or cells |
| US7049413B2 (en) | 2001-05-18 | 2006-05-23 | Ludwig Institute For Cancer Research | MAGE-A3 peptides presented by HLA class II molecules |
| IL160359A0 (en) | 2001-08-31 | 2004-07-25 | Avidex Ltd | Soluble t cell receptor |
| KR100467944B1 (ko) | 2002-07-15 | 2005-01-24 | 엘지.필립스 엘시디 주식회사 | 반사투과형 액정표시장치 및 그의 제조방법 |
| RU2355703C2 (ru) | 2002-10-09 | 2009-05-20 | Медиджен Лимитед | Одноцепочечные рекомбинантные т-клеточные рецепторы |
| GB0304068D0 (en) * | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
| JP5276846B2 (ja) | 2005-09-13 | 2013-08-28 | 国立大学法人三重大学 | Ｔ細胞レセプターをコードする核酸が挿入されてなるベクター及び該レセプターを発現する細胞 |
| US20120009162A1 (en) * | 2009-04-03 | 2012-01-12 | Masaki Yasukawa | T cell receptor and nucleic acid encoding the receptor |
| HRP20171164T1 (hr) | 2010-09-20 | 2017-10-20 | Biontech Cell & Gene Therapies Gmbh | Antigen-specifični t stanični receptori i t stanični epitopi |
| WO2012054825A1 (en) | 2010-10-22 | 2012-04-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mage-a3 t cell receptors and related materials and methods of use |
| AU2012309830B2 (en) | 2011-09-15 | 2017-03-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors recognizing HLA-A1- or HLA-Cw7-restricted mage |
| WO2013041865A1 (en) * | 2011-09-22 | 2013-03-28 | Immunocore Limited | T cell receptors |
| SG11201400521PA (en) * | 2011-10-14 | 2014-08-28 | Teva Pharmaceuticals Australia Pty Ltd | ANTIBODIES TO CD1d |
| KR20150131208A (ko) | 2013-03-13 | 2015-11-24 | 이미지냅 인코포레이티드 | Cd８에의 항원 결합 구조체들 |
| GB201313377D0 (en) * | 2013-07-26 | 2013-09-11 | Adaptimmune Ltd | T cell receptors |
| GB201417803D0 (en) | 2014-10-08 | 2014-11-19 | Adaptimmune Ltd | T cell receptors |
| KR102349677B1 (ko) | 2015-05-28 | 2022-01-12 | 카이트 파마 인코포레이티드 | T 세포 요법을 위해 환자를 컨디셔닝하는 방법 |
| KR20180063320A (ko) | 2015-10-20 | 2018-06-11 | 카이트 파마 인코포레이티드 | T 세포 요법을 위한 t 세포를 제조하는 방법 |
| CN106749620B (zh) | 2016-03-29 | 2020-09-25 | 广东香雪精准医疗技术有限公司 | 识别mage-a1抗原短肽的t细胞受体 |
| KR20190059874A (ko) | 2016-04-08 | 2019-05-31 | 어댑티뮨 리미티드 | T 세포 수용체 |
| DK3440106T3 (da) | 2016-04-08 | 2021-10-04 | Adaptimmune Ltd | T-cellereceptorer |
| BR112018070637A2 (pt) | 2016-04-08 | 2019-02-05 | Adaptimmune Ltd | receptores de células t |
| GB201616238D0 (en) | 2016-09-23 | 2016-11-09 | Adaptimmune Ltd | Modified T cells |
| JP7037577B2 (ja) | 2017-03-15 | 2022-03-16 | フレッド ハッチンソン キャンサー リサーチ センター | 高親和性ｍａｇｅ－ａ１特異的ｔｃｒ及びその使用 |
| GB201713078D0 (en) | 2017-08-15 | 2017-09-27 | Adaptimmune Ltd | T Cell Modification |
| WO2020049496A1 (en) | 2018-09-05 | 2020-03-12 | Glaxosmithkline Intellectual Property Development Limited | T cell modification |
-
2017
- 2017-04-10 DK DK17723016.6T patent/DK3440106T3/da active
- 2017-04-10 RS RS20211132A patent/RS62623B1/sr unknown
- 2017-04-10 SI SI201730915T patent/SI3440106T1/sl unknown
- 2017-04-10 IL IL262128A patent/IL262128B2/en unknown
- 2017-04-10 MX MX2018012269A patent/MX395611B/es unknown
- 2017-04-10 CA CA3020058A patent/CA3020058A1/en active Pending
- 2017-04-10 CN CN202310190624.3A patent/CN116217703A/zh active Pending
- 2017-04-10 JP JP2018552872A patent/JP7240176B2/ja active Active
- 2017-04-10 HU HUE17723016A patent/HUE056433T2/hu unknown
- 2017-04-10 LT LTEPPCT/EP2017/058580T patent/LT3440106T/lt unknown
- 2017-04-10 CN CN201780031710.2A patent/CN109476725B/zh active Active
- 2017-04-10 SM SM20210564T patent/SMT202100564T1/it unknown
- 2017-04-10 SG SG11201808751SA patent/SG11201808751SA/en unknown
- 2017-04-10 ES ES17723016T patent/ES2891321T3/es active Active
- 2017-04-10 HR HRP20211493TT patent/HRP20211493T1/hr unknown
- 2017-04-10 RU RU2018138838A patent/RU2018138838A/ru unknown
- 2017-04-10 PL PL17723016T patent/PL3440106T3/pl unknown
- 2017-04-10 WO PCT/EP2017/058580 patent/WO2017174824A1/en not_active Ceased
- 2017-04-10 AU AU2017248122A patent/AU2017248122B2/en active Active
- 2017-04-10 KR KR1020237007661A patent/KR102747867B1/ko active Active
- 2017-04-10 EP EP17723016.6A patent/EP3440106B1/en active Active
- 2017-04-10 PT PT177230166T patent/PT3440106T/pt unknown
- 2017-04-10 KR KR1020187032168A patent/KR102523449B1/ko active Active
- 2017-04-10 BR BR112018070625-6A patent/BR112018070625A2/pt active Search and Examination
- 2017-04-10 EP EP21193647.1A patent/EP3988565A1/en active Pending
-
2018
- 2018-10-05 MX MX2022011309A patent/MX2022011309A/es unknown
- 2018-10-08 US US16/154,192 patent/US11286289B2/en active Active
- 2018-10-15 ZA ZA2018/06866A patent/ZA201806866B/en unknown
-
2020
- 2020-10-16 ZA ZA2020/06432A patent/ZA202006432B/en unknown
-
2021
- 2021-10-05 CY CY20211100860T patent/CY1124664T1/el unknown
- 2021-10-14 US US17/501,122 patent/US11725040B2/en active Active
-
2022
- 2022-08-17 US US17/820,529 patent/US11572400B1/en active Active
- 2022-10-20 AU AU2022256177A patent/AU2022256177B2/en active Active
-
2023
- 2023-03-03 JP JP2023032695A patent/JP7577149B2/ja active Active
- 2023-06-22 US US18/339,663 patent/US12180260B2/en active Active
-
2024
- 2024-11-21 US US18/955,832 patent/US20250084146A1/en active Pending
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