JP2023065516A5 - - Google Patents
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- Publication number
- JP2023065516A5 JP2023065516A5 JP2023026870A JP2023026870A JP2023065516A5 JP 2023065516 A5 JP2023065516 A5 JP 2023065516A5 JP 2023026870 A JP2023026870 A JP 2023026870A JP 2023026870 A JP2023026870 A JP 2023026870A JP 2023065516 A5 JP2023065516 A5 JP 2023065516A5
- Authority
- JP
- Japan
- Prior art keywords
- promoter
- nucleic acid
- acid molecule
- tuberin
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762507358P | 2017-05-17 | 2017-05-17 | |
| US62/507,358 | 2017-05-17 | ||
| PCT/US2018/033247 WO2018213618A1 (en) | 2017-05-17 | 2018-05-17 | Gene therapy for tuberous sclerosis |
| JP2019558745A JP7235676B2 (ja) | 2017-05-17 | 2018-05-17 | 結節性硬化症の遺伝子治療 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019558745A Division JP7235676B2 (ja) | 2017-05-17 | 2018-05-17 | 結節性硬化症の遺伝子治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023065516A JP2023065516A (ja) | 2023-05-12 |
| JP2023065516A5 true JP2023065516A5 (enExample) | 2023-10-23 |
| JP7725514B2 JP7725514B2 (ja) | 2025-08-19 |
Family
ID=64274693
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019558745A Active JP7235676B2 (ja) | 2017-05-17 | 2018-05-17 | 結節性硬化症の遺伝子治療 |
| JP2023026870A Active JP7725514B2 (ja) | 2017-05-17 | 2023-02-24 | 結節性硬化症の遺伝子治療 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019558745A Active JP7235676B2 (ja) | 2017-05-17 | 2018-05-17 | 結節性硬化症の遺伝子治療 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11958887B2 (enExample) |
| EP (2) | EP4413990A3 (enExample) |
| JP (2) | JP7235676B2 (enExample) |
| CA (1) | CA3061656A1 (enExample) |
| ES (1) | ES2978297T3 (enExample) |
| WO (1) | WO2018213618A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11958887B2 (en) * | 2017-05-17 | 2024-04-16 | The General Hospital Corporation | Gene therapy for tuberous sclerosis |
| EP4355766A1 (en) * | 2021-06-14 | 2024-04-24 | Bridgebio Gene Therapy Research, Inc. | Gene therapy for tuberous sclerosis |
| EP4688004A2 (en) * | 2023-05-17 | 2026-02-11 | Research Institute at Nationwide Children's Hospital | Protein engineering micro-tuberin gene therapy candidates for tuberous sclerosis complex type 2 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5478745A (en) | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
| US6884419B1 (en) * | 1996-12-23 | 2005-04-26 | Kyowa Hakko Kogyo, Co., Ltd. | hG-CSF fusion polypeptide having c-mpl activity, DNA coding for same and methods of treating anemia using same |
| DK2359869T3 (en) | 2001-12-17 | 2019-04-15 | Univ Pennsylvania | Sequences of adeno-associated virus (AAV) serotype 8, vectors containing these, and uses thereof |
| EP1546369A4 (en) | 2002-08-12 | 2007-01-17 | Univ Michigan | DIAGNOSIS AND TREATMENT OF DISEASES THROUGH DEFECTS IN THE TUBEROUS SKLEROSEPFAD |
| WO2004058166A2 (en) | 2002-12-23 | 2004-07-15 | Vical Incorporated | Codon-optimized polynucleotide-based vaccines against human cytomegalovirus infection |
| CN1897977A (zh) | 2003-10-20 | 2007-01-17 | Ns基因公司 | 帕金森氏病的体内基因治疗 |
| CL2008000707A1 (es) * | 2007-03-13 | 2008-09-22 | Hoffmann La Roche | Conjugado de polipeptidos antifusogenicos y polipeptidos derivados de la cabeza globular del factor del complemento c1q; composicion farmaceutica que lo comprende; su uso para tratar infecciones viricas; y metodo de produccion. |
| US7561972B1 (en) | 2008-06-06 | 2009-07-14 | Dna Twopointo, Inc. | Synthetic nucleic acids for expression of encoded proteins |
| US7561973B1 (en) | 2008-07-31 | 2009-07-14 | Dna Twopointo, Inc. | Methods for determining properties that affect an expression property value of polynucleotides in an expression system |
| WO2011020118A1 (en) | 2009-08-14 | 2011-02-17 | Theramind Research, Llc | Methods and compositions for treatment of tuberous sclerosis complex |
| US9249425B2 (en) | 2011-05-16 | 2016-02-02 | The Trustees Of The University Of Pennslyvania | Proviral plasmids and production of recombinant adeno-associated virus |
| WO2013151664A1 (en) * | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
| EP4223770A3 (en) | 2012-11-05 | 2023-10-18 | Foundation Medicine, Inc. | Novel fusion molecules and uses thereof |
| US11958887B2 (en) * | 2017-05-17 | 2024-04-16 | The General Hospital Corporation | Gene therapy for tuberous sclerosis |
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2018
- 2018-05-17 US US16/613,907 patent/US11958887B2/en active Active
- 2018-05-17 EP EP24168056.0A patent/EP4413990A3/en active Pending
- 2018-05-17 WO PCT/US2018/033247 patent/WO2018213618A1/en not_active Ceased
- 2018-05-17 EP EP18801604.2A patent/EP3624856B1/en active Active
- 2018-05-17 ES ES18801604T patent/ES2978297T3/es active Active
- 2018-05-17 CA CA3061656A patent/CA3061656A1/en active Pending
- 2018-05-17 JP JP2019558745A patent/JP7235676B2/ja active Active
-
2023
- 2023-02-24 JP JP2023026870A patent/JP7725514B2/ja active Active
-
2024
- 2024-03-12 US US18/602,622 patent/US20240343768A1/en active Pending