JP2023052458A5 - - Google Patents
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- JP2023052458A5 JP2023052458A5 JP2023005585A JP2023005585A JP2023052458A5 JP 2023052458 A5 JP2023052458 A5 JP 2023052458A5 JP 2023005585 A JP2023005585 A JP 2023005585A JP 2023005585 A JP2023005585 A JP 2023005585A JP 2023052458 A5 JP2023052458 A5 JP 2023052458A5
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- JP
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- Prior art keywords
- pharmaceutical composition
- antigen
- antibody
- binding fragment
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 46
- 239000000427 antigen Substances 0.000 claims 37
- 102000036639 antigens Human genes 0.000 claims 37
- 108091007433 antigens Proteins 0.000 claims 37
- 239000012634 fragment Substances 0.000 claims 37
- 208000000592 Nasal Polyps Diseases 0.000 claims 21
- 238000011282 treatment Methods 0.000 claims 18
- 208000036071 Rhinorrhea Diseases 0.000 claims 14
- 206010039101 Rhinorrhoea Diseases 0.000 claims 14
- 102000010787 Interleukin-4 Receptors Human genes 0.000 claims 13
- 108010038486 Interleukin-4 Receptors Proteins 0.000 claims 13
- 208000027157 chronic rhinosinusitis Diseases 0.000 claims 11
- 239000003246 corticosteroid Substances 0.000 claims 10
- 229960001334 corticosteroids Drugs 0.000 claims 10
- 238000001356 surgical procedure Methods 0.000 claims 8
- 208000016366 nasal cavity polyp Diseases 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 238000012423 maintenance Methods 0.000 claims 6
- 230000009885 systemic effect Effects 0.000 claims 6
- 206010028735 Nasal congestion Diseases 0.000 claims 5
- 208000024891 symptom Diseases 0.000 claims 5
- 238000002591 computed tomography Methods 0.000 claims 4
- 230000008786 sensory perception of smell Effects 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 206010002653 Anosmia Diseases 0.000 claims 3
- 206010019233 Headaches Diseases 0.000 claims 3
- 230000003247 decreasing effect Effects 0.000 claims 3
- 231100000869 headache Toxicity 0.000 claims 3
- 206010009137 Chronic sinusitis Diseases 0.000 claims 2
- 206010016059 Facial pain Diseases 0.000 claims 2
- 206010028748 Nasal obstruction Diseases 0.000 claims 2
- 235000019558 anosmia Nutrition 0.000 claims 2
- 229940090047 auto-injector Drugs 0.000 claims 2
- 229950003468 dupilumab Drugs 0.000 claims 2
- 238000011418 maintenance treatment Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229940071643 prefilled syringe Drugs 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000002146 bilateral effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 230000001815 facial effect Effects 0.000 claims 1
- 229960002744 mometasone furoate Drugs 0.000 claims 1
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims 1
- 239000007922 nasal spray Substances 0.000 claims 1
- 229940097496 nasal spray Drugs 0.000 claims 1
- 229940124624 oral corticosteroid Drugs 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025003986A JP2025063155A (ja) | 2014-11-14 | 2025-01-10 | Ｉｌ－４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462080092P | 2014-11-14 | 2014-11-14 | |
| US62/080,092 | 2014-11-14 | ||
| US201462083821P | 2014-11-24 | 2014-11-24 | |
| US62/083,821 | 2014-11-24 | ||
| US201562158832P | 2015-05-08 | 2015-05-08 | |
| US62/158,832 | 2015-05-08 | ||
| US201562199305P | 2015-07-31 | 2015-07-31 | |
| US62/199,305 | 2015-07-31 | ||
| EP15306632 | 2015-10-14 | ||
| EP15306632.9 | 2015-10-14 | ||
| JP2021001858A JP7216122B2 (ja) | 2014-11-14 | 2021-01-08 | Ｉｌ－４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021001858A Division JP7216122B2 (ja) | 2014-11-14 | 2021-01-08 | Ｉｌ－４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025003986A Division JP2025063155A (ja) | 2014-11-14 | 2025-01-10 | Ｉｌ－４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023052458A JP2023052458A (ja) | 2023-04-11 |
| JP2023052458A5 true JP2023052458A5 (https=) | 2023-10-12 |
Family
ID=54330704
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525897A Active JP6861630B2 (ja) | 2014-11-14 | 2015-11-13 | Ｉｌ−４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
| JP2023005585A Pending JP2023052458A (ja) | 2014-11-14 | 2023-01-18 | Ｉｌ－４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
| JP2025003986A Pending JP2025063155A (ja) | 2014-11-14 | 2025-01-10 | Ｉｌ－４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525897A Active JP6861630B2 (ja) | 2014-11-14 | 2015-11-13 | Ｉｌ−４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025003986A Pending JP2025063155A (ja) | 2014-11-14 | 2025-01-10 | Ｉｌ－４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10066017B2 (https=) |
| EP (1) | EP3218412A1 (https=) |
| JP (3) | JP6861630B2 (https=) |
| KR (2) | KR20170081262A (https=) |
| CN (1) | CN107206073A (https=) |
| AU (3) | AU2015346150B2 (https=) |
| CA (2) | CA3246946A1 (https=) |
| IL (4) | IL303337B2 (https=) |
| MX (2) | MX2017006286A (https=) |
| RU (1) | RU2734490C2 (https=) |
| WO (1) | WO2016077675A1 (https=) |
Families Citing this family (30)
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| AU2014284235C1 (en) | 2013-06-21 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Methods for treating nasal polyposis by administering an IL-4R antagonist |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| IL315136A (en) | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| KR102695088B1 (ko) | 2014-02-28 | 2024-08-16 | 리제너론 파아마슈티컬스, 인크. | Ｉｌ-4ｒ 길항제의 투여에 의한 피부 감염의 치료 방법 |
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| BR112020020387A2 (pt) * | 2018-05-13 | 2021-01-19 | Regeneron Pharmaceuticals, Inc. | Métodos para o tratamento de dermatite atópica por administração de um inibidor de il-4r |
| AU2019302642B2 (en) | 2018-07-10 | 2025-10-30 | Regeneron Pharmaceuticals, Inc. | Modifying binding molecules to minimize pre-existing interactions |
| CN110746507B (zh) | 2018-12-25 | 2020-06-26 | 江苏荃信生物医药有限公司 | 抗人白介素4受体α单克隆抗体及其应用 |
| EP3911632A1 (en) | 2019-01-15 | 2021-11-24 | Empirico Inc. | Prodrugs of alox-15 inhibitors and methods of using the same |
| CN113597328B (zh) | 2019-03-21 | 2025-10-31 | 瑞泽恩制药公司 | 用于治疗过敏症的il-4/il-13途径抑制剂和浆细胞消融的组合 |
| WO2021011614A1 (en) | 2019-07-16 | 2021-01-21 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
| CN114173816A (zh) | 2019-08-05 | 2022-03-11 | 瑞泽恩制药公司 | 通过施用il-4r拮抗剂治疗特应性皮炎的方法 |
| JP7836754B2 (ja) | 2019-08-05 | 2026-03-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｉｌ－４ｒアンタゴニストを投与することによりアレルギーを治療しアレルゲン特異的免疫療法を増強するための方法 |
| EP3992974A1 (en) | 2020-11-02 | 2022-05-04 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| KR20220110829A (ko) * | 2019-12-09 | 2022-08-09 | 사노피 바이오테크놀로지 | 디지털 식별된 il-4/il-13 관련 장애의 치료 방법 |
| KR20240038841A (ko) * | 2022-09-16 | 2024-03-26 | 연세대학교 산학협력단 | 신규한 인간 인터류킨-4 수용체 결합 나노바디 및 이의 용도 |
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| EP4623903A1 (en) | 2024-03-28 | 2025-10-01 | Fresenius Kabi Deutschland GmbH | Pharmaceutical composition comprising dupilumab |
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2015
- 2015-11-13 CA CA3246946A patent/CA3246946A1/en active Pending
- 2015-11-13 IL IL303337A patent/IL303337B2/en unknown
- 2015-11-13 AU AU2015346150A patent/AU2015346150B2/en active Active
- 2015-11-13 RU RU2017120437A patent/RU2734490C2/ru active
- 2015-11-13 WO PCT/US2015/060540 patent/WO2016077675A1/en not_active Ceased
- 2015-11-13 KR KR1020177015962A patent/KR20170081262A/ko not_active Ceased
- 2015-11-13 MX MX2017006286A patent/MX2017006286A/es unknown
- 2015-11-13 KR KR1020237038116A patent/KR20230158131A/ko not_active Ceased
- 2015-11-13 CA CA2967602A patent/CA2967602C/en active Active
- 2015-11-13 CN CN201580073344.8A patent/CN107206073A/zh active Pending
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- 2015-11-13 US US14/940,431 patent/US10066017B2/en active Active
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- 2017-05-12 MX MX2023000079A patent/MX2023000079A/es unknown
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- 2021-11-15 AU AU2021269269A patent/AU2021269269A1/en not_active Abandoned
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