JP2023033538A5 - - Google Patents
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- Publication number
- JP2023033538A5 JP2023033538A5 JP2023005643A JP2023005643A JP2023033538A5 JP 2023033538 A5 JP2023033538 A5 JP 2023033538A5 JP 2023005643 A JP2023005643 A JP 2023005643A JP 2023005643 A JP2023005643 A JP 2023005643A JP 2023033538 A5 JP2023033538 A5 JP 2023033538A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- concentration
- mannitol
- composition
- arginine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 7
- 229930195725 Mannitol Natural products 0.000 claims 7
- 235000010355 mannitol Nutrition 0.000 claims 7
- 239000000594 mannitol Substances 0.000 claims 7
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 6
- 229930064664 L-arginine Natural products 0.000 claims 6
- 235000014852 L-arginine Nutrition 0.000 claims 6
- WXJFKKQWPMNTIM-VWLOTQADSA-N [(2s)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic acid Chemical compound CCCCCCCCCCCCCCCCOCCCOP(O)(=O)CO[C@H](CO)CN1C=CC(N)=NC1=O WXJFKKQWPMNTIM-VWLOTQADSA-N 0.000 claims 5
- 229950005107 brincidofovir Drugs 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 239000013618 particulate matter Substances 0.000 claims 3
- 208000036142 Viral infection Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000012535 impurity Substances 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 206010059024 Gastrointestinal toxicity Diseases 0.000 claims 1
- 206010018910 Haemolysis Diseases 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 1
- 241001631646 Papillomaviridae Species 0.000 claims 1
- 241001505332 Polyomavirus sp. Species 0.000 claims 1
- 231100000414 gastrointestinal toxicity Toxicity 0.000 claims 1
- 230000008588 hemolysis Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
Applications Claiming Priority (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662355844P | 2016-06-28 | 2016-06-28 | |
| US62/355,844 | 2016-06-28 | ||
| US201662394665P | 2016-09-14 | 2016-09-14 | |
| US62/394,665 | 2016-09-14 | ||
| US201762446213P | 2017-01-13 | 2017-01-13 | |
| US62/446,213 | 2017-01-13 | ||
| US201762465053P | 2017-02-28 | 2017-02-28 | |
| US62/465,053 | 2017-02-28 | ||
| US201762507397P | 2017-05-17 | 2017-05-17 | |
| US62/507,397 | 2017-05-17 | ||
| US201762512825P | 2017-05-31 | 2017-05-31 | |
| US62/512,825 | 2017-05-31 | ||
| JP2018568195A JP6878473B2 (ja) | 2016-06-28 | 2017-06-28 | ブリンシドフォビルの製剤 |
| JP2021075612A JP7221485B2 (ja) | 2016-06-28 | 2021-04-28 | ブリンシドフォビルの製剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021075612A Division JP7221485B2 (ja) | 2016-06-28 | 2021-04-28 | ブリンシドフォビルの製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023033538A JP2023033538A (ja) | 2023-03-10 |
| JP2023033538A5 true JP2023033538A5 (https=) | 2023-04-28 |
| JP7407984B2 JP7407984B2 (ja) | 2024-01-04 |
Family
ID=59313330
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568195A Active JP6878473B2 (ja) | 2016-06-28 | 2017-06-28 | ブリンシドフォビルの製剤 |
| JP2021075612A Active JP7221485B2 (ja) | 2016-06-28 | 2021-04-28 | ブリンシドフォビルの製剤 |
| JP2023005643A Active JP7407984B2 (ja) | 2016-06-28 | 2023-01-18 | ブリンシドフォビルの製剤 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568195A Active JP6878473B2 (ja) | 2016-06-28 | 2017-06-28 | ブリンシドフォビルの製剤 |
| JP2021075612A Active JP7221485B2 (ja) | 2016-06-28 | 2021-04-28 | ブリンシドフォビルの製剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20170368082A1 (https=) |
| EP (2) | EP4295853A3 (https=) |
| JP (3) | JP6878473B2 (https=) |
| CN (4) | CN119139329A (https=) |
| AU (2) | AU2017290703B2 (https=) |
| DK (1) | DK3474822T3 (https=) |
| ES (1) | ES3037596T3 (https=) |
| FI (1) | FI3474822T3 (https=) |
| PL (1) | PL3474822T3 (https=) |
| PT (1) | PT3474822T (https=) |
| WO (1) | WO2018005676A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2999476T3 (en) | 2013-11-15 | 2018-09-03 | Chimerix Inc | MORPHIC FORMS OF HEXADECYLOXYPROPYL PHOSPHONATE TESTERS |
| EP4295853A3 (en) * | 2016-06-28 | 2024-03-06 | Emergent BioDefense Operations Lansing LLC | Formulations of brincidofovir |
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| AU2020214796A1 (en) | 2019-01-30 | 2021-07-29 | Truebinding, Inc. | Anti-Gal3 antibodies and uses thereof |
| WO2021242776A2 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| CN114073772A (zh) * | 2020-08-18 | 2022-02-22 | 上海市公共卫生临床中心 | 铁螯合剂在制备用于治疗或预防多瘤病毒感染的药物中的用途 |
| CN114558022B (zh) * | 2022-02-16 | 2023-11-17 | 华中农业大学 | 布林西多福韦在制备抗伪狂犬病毒药物中的应用 |
| CN114732821A (zh) * | 2022-04-24 | 2022-07-12 | 华中农业大学 | 西多福韦的前药在制备防治非洲猪瘟药物中的应用 |
| JP7417339B1 (ja) | 2023-08-07 | 2024-01-18 | シンバイオ製薬株式会社 | アデノウイルス感染又はアデノウイルス感染に伴う疾患の治療 |
| WO2025072782A1 (en) * | 2023-09-29 | 2025-04-03 | Symbio Pharmaceuticals Limited | Brincidofovir for treatment of multiple sclerosis |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60038038T2 (de) | 1999-12-03 | 2009-02-12 | The Regents of The University of California at San Diego, La Jolla | Phosphonatverbindungen |
| JP4136340B2 (ja) * | 2000-08-18 | 2008-08-20 | 武田薬品工業株式会社 | 注射剤 |
| JP2008538354A (ja) | 2005-04-08 | 2008-10-23 | キメリクス，インコーポレイテッド | ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法 |
| JP2008535862A (ja) | 2005-04-08 | 2008-09-04 | キメリクス，インコーポレイテッド | ポックスウイルス感染の治療のための化合物、組成物および方法 |
| WO2008133966A1 (en) * | 2007-04-27 | 2008-11-06 | Chimerix, Inc. | Methods of reducing nephrotoxicity in subjects administered with nucleoside |
| JP2011116658A (ja) * | 2008-03-13 | 2011-06-16 | Chemo-Sero-Therapeutic Research Inst | 豚萎縮性鼻炎用薬剤の製造方法 |
| US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| WO2011017253A1 (en) | 2009-08-03 | 2011-02-10 | Chimerix, Inc. | Composition and methods of treating viral infections and viral induced tumors |
| WO2011053812A1 (en) | 2009-10-30 | 2011-05-05 | Chimerix, Inc. | Methods of treating viral associated diseases |
| PT2508170E (pt) | 2009-12-03 | 2015-10-16 | Shanghai Hengrui Pharm Co Ltd | Lipossoma de irinotecano ou o seu cloridrato e seu método de preparação |
| US20110263536A1 (en) | 2010-04-22 | 2011-10-27 | Chimerix, Inc. | Methods of Treating Orthopox Virus Infections and Associated Diseases |
| ES2604137T3 (es) | 2010-08-31 | 2017-03-03 | Chimerix, Inc. | Derivados de éster de fosfonato y métodos de síntesis de los mismos |
| WO2013063436A1 (en) * | 2011-10-26 | 2013-05-02 | Chimerix, Inc. | Hexadecyloxypropyl cidofovir for the treatment of double-stranded dna virus infection |
| WO2013163509A1 (en) | 2012-04-27 | 2013-10-31 | Chimerix, Inc. | A method of mitigating virus associated end-organ damage |
| UA119324C2 (uk) | 2013-04-02 | 2019-06-10 | Теміс Медікер Лімітед | Композиції фармацевтично активних речовин, що містять моноетиловий ефір діетиленгліколю або інші алкільні похідні |
| DK2999476T3 (en) * | 2013-11-15 | 2018-09-03 | Chimerix Inc | MORPHIC FORMS OF HEXADECYLOXYPROPYL PHOSPHONATE TESTERS |
| EP4295853A3 (en) * | 2016-06-28 | 2024-03-06 | Emergent BioDefense Operations Lansing LLC | Formulations of brincidofovir |
-
2017
- 2017-06-28 EP EP23195544.4A patent/EP4295853A3/en active Pending
- 2017-06-28 PL PL17737695.1T patent/PL3474822T3/pl unknown
- 2017-06-28 WO PCT/US2017/039804 patent/WO2018005676A1/en not_active Ceased
- 2017-06-28 PT PT177376951T patent/PT3474822T/pt unknown
- 2017-06-28 DK DK17737695.1T patent/DK3474822T3/da active
- 2017-06-28 JP JP2018568195A patent/JP6878473B2/ja active Active
- 2017-06-28 AU AU2017290703A patent/AU2017290703B2/en active Active
- 2017-06-28 CN CN202411127002.7A patent/CN119139329A/zh active Pending
- 2017-06-28 CN CN202210134248.1A patent/CN114569547A/zh active Pending
- 2017-06-28 CN CN201780040478.9A patent/CN109475497A/zh active Pending
- 2017-06-28 ES ES17737695T patent/ES3037596T3/es active Active
- 2017-06-28 CN CN202410393564.XA patent/CN118416082A/zh active Pending
- 2017-06-28 EP EP17737695.1A patent/EP3474822B1/en active Active
- 2017-06-28 FI FIEP17737695.1T patent/FI3474822T3/fi active
- 2017-06-28 US US15/636,393 patent/US20170368082A1/en not_active Abandoned
-
2019
- 2019-12-20 US US16/722,699 patent/US20200138835A1/en not_active Abandoned
-
2021
- 2021-04-28 JP JP2021075612A patent/JP7221485B2/ja active Active
-
2022
- 2022-07-25 US US17/872,921 patent/US12485131B2/en active Active
-
2023
- 2023-01-18 JP JP2023005643A patent/JP7407984B2/ja active Active
- 2023-06-28 AU AU2023204117A patent/AU2023204117B2/en active Active
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