JP2023025187A5 - - Google Patents
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- JP2023025187A5 JP2023025187A5 JP2022193805A JP2022193805A JP2023025187A5 JP 2023025187 A5 JP2023025187 A5 JP 2023025187A5 JP 2022193805 A JP2022193805 A JP 2022193805A JP 2022193805 A JP2022193805 A JP 2022193805A JP 2023025187 A5 JP2023025187 A5 JP 2023025187A5
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- Prior art keywords
- cell
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024200383A JP2025026930A (ja) | 2017-03-31 | 2024-11-18 | Ｔ細胞受容体シグナル伝達を阻害または調節することによって、ｔ細胞枯渇を処置する方法 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762479930P | 2017-03-31 | 2017-03-31 | |
| US62/479,930 | 2017-03-31 | ||
| JP2019553214A JP7249287B2 (ja) | 2017-03-31 | 2018-03-30 | Ｔ細胞受容体シグナル伝達を阻害または調節することによって、ｔ細胞枯渇を処置する方法 |
| PCT/US2018/025459 WO2018183888A2 (en) | 2017-03-31 | 2018-03-30 | Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553214A Division JP7249287B2 (ja) | 2017-03-31 | 2018-03-30 | Ｔ細胞受容体シグナル伝達を阻害または調節することによって、ｔ細胞枯渇を処置する方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024200383A Division JP2025026930A (ja) | 2017-03-31 | 2024-11-18 | Ｔ細胞受容体シグナル伝達を阻害または調節することによって、ｔ細胞枯渇を処置する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023025187A JP2023025187A (ja) | 2023-02-21 |
| JP2023025187A5 true JP2023025187A5 (https=) | 2023-04-13 |
| JP7674328B2 JP7674328B2 (ja) | 2025-05-09 |
Family
ID=63677091
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553214A Active JP7249287B2 (ja) | 2017-03-31 | 2018-03-30 | Ｔ細胞受容体シグナル伝達を阻害または調節することによって、ｔ細胞枯渇を処置する方法 |
| JP2019553220A Active JP7278961B2 (ja) | 2017-03-31 | 2018-03-30 | Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法 |
| JP2022193805A Active JP7674328B2 (ja) | 2017-03-31 | 2022-12-02 | Ｔ細胞受容体シグナル伝達を阻害または調節することによって、ｔ細胞枯渇を処置する方法 |
| JP2023011257A Pending JP2023055805A (ja) | 2017-03-31 | 2023-01-27 | Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法 |
| JP2024123405A Pending JP2024153812A (ja) | 2017-03-31 | 2024-07-30 | Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法 |
| JP2024200383A Pending JP2025026930A (ja) | 2017-03-31 | 2024-11-18 | Ｔ細胞受容体シグナル伝達を阻害または調節することによって、ｔ細胞枯渇を処置する方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553214A Active JP7249287B2 (ja) | 2017-03-31 | 2018-03-30 | Ｔ細胞受容体シグナル伝達を阻害または調節することによって、ｔ細胞枯渇を処置する方法 |
| JP2019553220A Active JP7278961B2 (ja) | 2017-03-31 | 2018-03-30 | Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023011257A Pending JP2023055805A (ja) | 2017-03-31 | 2023-01-27 | Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法 |
| JP2024123405A Pending JP2024153812A (ja) | 2017-03-31 | 2024-07-30 | Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法 |
| JP2024200383A Pending JP2025026930A (ja) | 2017-03-31 | 2024-11-18 | Ｔ細胞受容体シグナル伝達を阻害または調節することによって、ｔ細胞枯渇を処置する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20200101108A1 (https=) |
| EP (2) | EP3600323A4 (https=) |
| JP (6) | JP7249287B2 (https=) |
| CN (3) | CN118161496A (https=) |
| AU (3) | AU2018243571B2 (https=) |
| CA (2) | CA3057372A1 (https=) |
| WO (2) | WO2018183888A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111699001A (zh) * | 2017-12-07 | 2020-09-22 | 尤利乌斯·马克西米利安维尔茨堡大学 | 达沙替尼和其他酪氨酸激酶抑制剂对基因修饰的嵌合抗原受体t细胞的功能的控制和调节 |
| US20210393628A1 (en) * | 2018-10-30 | 2021-12-23 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for modulating t cell exhaustion |
| WO2020097403A1 (en) * | 2018-11-08 | 2020-05-14 | Juno Therapeutics, Inc. | Methods and combinations for treatment and t cell modulation |
| WO2020168122A1 (en) | 2019-02-13 | 2020-08-20 | Beam Therapeutics Inc. | Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence |
| KR20210135255A (ko) * | 2019-03-01 | 2021-11-12 | 내셔널 유니버시티 오브 싱가포르 | 조작된 면역 세포 |
| CN110157680A (zh) * | 2019-05-08 | 2019-08-23 | 浙江大学 | 提高嵌合抗原受体t细胞疗效和作用持久性的细胞培养方法 |
| US20220275104A1 (en) * | 2019-08-01 | 2022-09-01 | Mie University | Gd2 binding molecule |
| EP4034138A4 (en) | 2019-09-27 | 2024-07-31 | Beam Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS |
| GB202000934D0 (en) * | 2020-01-22 | 2020-03-04 | Ucl Business Ltd | Engineered immune cells |
| US12365871B2 (en) | 2020-04-28 | 2025-07-22 | Lyell Immunopharma, Inc. | Methods for culturing cells |
| JP7785699B2 (ja) * | 2020-05-29 | 2025-12-15 | シャンハイ ジュンセル セラピューティクス カンパニー リミテッド | 腫瘍浸潤リンパ球の種細胞培地及びその使用 |
| PE20230435A1 (es) * | 2020-06-19 | 2023-03-08 | Chugai Pharmaceutical Co Ltd | Moleculas de union al antigeno anti-celulas t para usarse en combinacion con un inhibidor de angiogenesis |
| CN116322691A (zh) * | 2020-09-24 | 2023-06-23 | 豪夫迈·罗氏有限公司 | T细胞双特异性抗体相关不良反应的预防或减轻 |
| AU2021347359A1 (en) | 2020-09-25 | 2023-05-18 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| AU2021368741A1 (en) * | 2020-10-30 | 2023-06-08 | The University Of North Carolina At Chapel Hill | Dual targeting chimeric antigen receptors |
| WO2022210487A1 (ja) * | 2021-03-29 | 2022-10-06 | タカラバイオ株式会社 | 抗原に特異的な受容体を発現する免疫細胞の製造方法 |
| EP4071248A1 (en) | 2021-04-07 | 2022-10-12 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Means and methods for enhancing receptor-targeted gene transfer |
| WO2022234063A1 (en) * | 2021-05-07 | 2022-11-10 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Method for constitutive malt1 protease activation |
| CN113533729B (zh) * | 2021-06-15 | 2024-09-06 | 北京大学人民医院 | 一种鉴定aml患者骨髓中nk细胞耗竭的研究方法及其应用 |
| CA3225252A1 (en) | 2021-07-14 | 2023-01-19 | Jordan JARJOUR | Engineered t cell receptors fused to binding domains from antibodies |
| CN115677861B (zh) * | 2021-07-29 | 2026-03-06 | 上海科技大学 | 一种泛素偶联修饰的嵌合抗原受体及免疫细胞 |
| KR20240112376A (ko) | 2021-10-28 | 2024-07-18 | 라이엘 이뮤노파마, 인크. | c-Jun을 발현하는 세포를 배양하는 방법 |
| JP2024540099A (ja) | 2021-10-28 | 2024-10-31 | ライエル・イミュノファーマ・インコーポレイテッド | Ｒｏｒ１結合タンパク質を発現する細胞を培養する方法 |
| CN119546328A (zh) | 2022-04-08 | 2025-02-28 | 再生元制药公司 | 多部分受体和信号传导复合物 |
| CA3258445A1 (en) * | 2022-06-13 | 2023-12-21 | The Regents Of The University Of California | ENHANCED GLYCAN-DEPENDENT CHIMERIC ANTIGEN RECEPTOR CELLS |
| GB202218144D0 (en) * | 2022-12-02 | 2023-01-18 | Univ Oxford Innovation Ltd | Product |
| CN116121196B (zh) * | 2022-12-23 | 2025-07-22 | 广州安捷生物医学技术有限公司 | 一种调控car-t细胞的方法与应用 |
| WO2025221871A1 (en) * | 2024-04-16 | 2025-10-23 | The Trustees Of Columbia University In The City Of New York | Expansion, propagation, and modulation of immune cell subsets by peptides |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2168456T3 (es) | 1995-01-16 | 2002-06-16 | North Sydney Area Health Serv | Peptidos que afectan a los linfocitos t. |
| US20050070478A1 (en) | 1996-06-11 | 2005-03-31 | Northern Sydney Area Health Services | T cell antigen receptor peptides |
| US20050113564A1 (en) | 2003-11-05 | 2005-05-26 | St. Jude Children's Research Hospital | Chimeric receptors with 4-1BB stimulatory signaling domain |
| GB0523954D0 (en) | 2005-11-24 | 2006-01-04 | Ucb Celltech | Bioassays |
| US9334330B2 (en) | 2006-10-10 | 2016-05-10 | Universite De Nantes | Use of monoclonal antibodies specific to the O-acetylated form of GD2 ganglioside for the treatment of certain cancers |
| US8173792B2 (en) * | 2007-02-09 | 2012-05-08 | The Board Of Trustees Of The Leland Stanford Junior University | Method for regulating protein function in cells using synthetic small molecules |
| ATE538377T1 (de) | 2007-04-02 | 2012-01-15 | Acoustic Cytometry Systems Inc | Verfahren zur verbesserten analyse von in einem akustischen feld fokussierten zellen und partikeln |
| EP3467101A3 (en) | 2010-09-08 | 2019-06-19 | Baylor College of Medicine | Immunotherapy of brain tumor using geneticially engineered gd2-specific t cells |
| US9845362B2 (en) | 2010-10-08 | 2017-12-19 | The University Of North Carolina At Charlotte | Compositions comprising chimeric antigen receptors, T cells comprising the same, and methods of using the same |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP2694549B1 (en) | 2011-04-08 | 2018-08-15 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer |
| HRP20211595T1 (hr) | 2011-05-24 | 2022-01-21 | BioNTech SE | Individualizirana cjepiva protiv raka |
| WO2013059593A1 (en) | 2011-10-20 | 2013-04-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-cd22 chimeric antigen receptors |
| AP2014007733A0 (en) * | 2011-12-02 | 2014-06-30 | Stillwater Mining Company | Precious metals recovery |
| EA033110B1 (ru) | 2012-04-11 | 2019-08-30 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерный рецептор антигена, направленный на антиген созревания b-клеток, кодирующая его нуклеиновая кислота, соответствующие экспрессионный вектор, клетка-хозяин, применения и способы |
| US9598489B2 (en) | 2012-10-05 | 2017-03-21 | The Trustees Of The Univeristy Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
| EP4303232A3 (en) | 2013-02-15 | 2024-04-17 | The Regents of The University of California | Chimeric antigen receptor and methods of use thereof |
| DK2958943T3 (da) | 2013-02-20 | 2019-12-09 | Univ Pennsylvania | Behandling af cancer ved anvendelse af humaniseret anti-EGFRvIII kimær antigenreceptor |
| US9446105B2 (en) | 2013-03-15 | 2016-09-20 | The Trustees Of The University Of Pennsylvania | Chimeric antigen receptor specific for folate receptor β |
| WO2014160627A1 (en) | 2013-03-25 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-cd276 polypeptides, proteins, and chimeric antigen receptors |
| EP3783098A1 (en) | 2013-05-14 | 2021-02-24 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| US9636340B2 (en) | 2013-11-12 | 2017-05-02 | Ayyappan K. Rajasekaran | Kinase inhibitors |
| GB201403972D0 (en) * | 2014-03-06 | 2014-04-23 | Ucl Business Plc | Chimeric antigen receptor |
| US11041021B2 (en) * | 2014-05-23 | 2021-06-22 | University Of Florida Research Foundation, Incorporated | Car based immunotherapy |
| SG11201700258VA (en) | 2014-07-16 | 2017-02-27 | Genentech Inc | Methods of treating cancer using tigit inhibitors and anti-cancer agents |
| SG10201913765YA (en) | 2014-07-21 | 2020-03-30 | Novartis Ag | Treatment of cancer using a cd33 chimeric antigen receptor |
| MX2017001079A (es) | 2014-07-24 | 2017-09-12 | Bluebird Bio Inc | Receptores de antígeno quiméricos de antígeno de maduración de células b (bcma). |
| ES2791248T3 (es) | 2014-08-19 | 2020-11-03 | Novartis Ag | Receptor antigénico quimérico (CAR) anti-CD123 para su uso en el tratamiento del cáncer |
| WO2016061368A1 (en) | 2014-10-15 | 2016-04-21 | The Children's Hospital Of Philadelphia | Compositions and methods for treating b-lymphoid malignancies |
| GB201500319D0 (en) * | 2015-01-09 | 2015-02-25 | Agency Science Tech & Res | Anti-PD-L1 antibodies |
| WO2016134284A1 (en) * | 2015-02-19 | 2016-08-25 | University Of Florida Research Foundation, Inc. | Chimeric antigen receptors and uses thereof |
| WO2016149254A1 (en) * | 2015-03-17 | 2016-09-22 | Chimera Bioengineering, Inc. | Smart car devices, de car polypeptides, side cars and uses thereof |
| GB201514328D0 (en) * | 2015-08-12 | 2015-09-23 | Sigmoid Pharma Ltd | Compositions |
| EP3405568A4 (en) | 2016-01-20 | 2019-12-04 | Fate Therapeutics, Inc. | COMPOUNDS AND METHODS FOR IMMUNOCELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES |
| WO2017172981A2 (en) * | 2016-03-29 | 2017-10-05 | University Of Southern California | Chimeric antigen receptors targeting cancer |
| MY209117A (en) | 2016-04-15 | 2025-06-23 | Novartis Ag | Compositions and methods for selective protein expression |
| WO2018106595A1 (en) * | 2016-12-05 | 2018-06-14 | Fate Therapeutics, Inc. | Compositions and methods for immune cell modulation in adoptive immunotherapies |
| CN111699001A (zh) * | 2017-12-07 | 2020-09-22 | 尤利乌斯·马克西米利安维尔茨堡大学 | 达沙替尼和其他酪氨酸激酶抑制剂对基因修饰的嵌合抗原受体t细胞的功能的控制和调节 |
| US20210393628A1 (en) | 2018-10-30 | 2021-12-23 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for modulating t cell exhaustion |
-
2018
- 2018-03-30 WO PCT/US2018/025459 patent/WO2018183888A2/en not_active Ceased
- 2018-03-30 JP JP2019553214A patent/JP7249287B2/ja active Active
- 2018-03-30 CN CN202410272411.XA patent/CN118161496A/zh active Pending
- 2018-03-30 US US16/499,762 patent/US20200101108A1/en active Pending
- 2018-03-30 AU AU2018243571A patent/AU2018243571B2/en active Active
- 2018-03-30 CN CN201880029045.8A patent/CN110603044B/zh active Active
- 2018-03-30 CA CA3057372A patent/CA3057372A1/en active Pending
- 2018-03-30 US US16/499,760 patent/US11938153B2/en active Active
- 2018-03-30 EP EP18775932.9A patent/EP3600323A4/en active Pending
- 2018-03-30 WO PCT/US2018/025394 patent/WO2018183842A1/en not_active Ceased
- 2018-03-30 JP JP2019553220A patent/JP7278961B2/ja active Active
- 2018-03-30 EP EP18777667.9A patent/EP3600357A4/en active Pending
- 2018-03-30 AU AU2018243664A patent/AU2018243664B2/en active Active
- 2018-03-30 CA CA3057505A patent/CA3057505A1/en active Pending
- 2018-03-30 CN CN201880028993.XA patent/CN110582280B/zh active Active
-
2022
- 2022-12-02 JP JP2022193805A patent/JP7674328B2/ja active Active
-
2023
- 2023-01-27 JP JP2023011257A patent/JP2023055805A/ja active Pending
-
2024
- 2024-02-21 US US18/583,096 patent/US20240293461A1/en active Pending
- 2024-06-07 AU AU2024203919A patent/AU2024203919A1/en active Pending
- 2024-07-30 JP JP2024123405A patent/JP2024153812A/ja active Pending
- 2024-11-18 JP JP2024200383A patent/JP2025026930A/ja active Pending
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