JP2022554187A - キメラサイトカイン改変抗体およびその使用方法 - Google Patents

キメラサイトカイン改変抗体およびその使用方法 Download PDF

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Publication number
JP2022554187A
JP2022554187A JP2022524084A JP2022524084A JP2022554187A JP 2022554187 A JP2022554187 A JP 2022554187A JP 2022524084 A JP2022524084 A JP 2022524084A JP 2022524084 A JP2022524084 A JP 2022524084A JP 2022554187 A JP2022554187 A JP 2022554187A
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sequence
antigen
binding fragment
antibody
cytokine
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JP2022554187A5 (https=
Inventor
ルイキ フアン
ボーン スミデル
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ミノトール セラピューティクス インコーポレイテッド
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Publication of JP2022554187A5 publication Critical patent/JP2022554187A5/ja
Priority to JP2025134949A priority Critical patent/JP2025169343A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2022524084A 2019-10-24 2020-10-23 キメラサイトカイン改変抗体およびその使用方法 Pending JP2022554187A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025134949A JP2025169343A (ja) 2019-10-24 2025-08-14 キメラサイトカイン改変抗体およびその使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962925740P 2019-10-24 2019-10-24
US62/925,740 2019-10-24
PCT/US2020/057209 WO2021081440A2 (en) 2019-10-24 2020-10-23 Chimeric cytokine modified antibodies and methods of use thereof

Related Child Applications (1)

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JP2025134949A Division JP2025169343A (ja) 2019-10-24 2025-08-14 キメラサイトカイン改変抗体およびその使用方法

Publications (2)

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JP2022554187A true JP2022554187A (ja) 2022-12-28
JP2022554187A5 JP2022554187A5 (https=) 2023-10-31

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JP2022524084A Pending JP2022554187A (ja) 2019-10-24 2020-10-23 キメラサイトカイン改変抗体およびその使用方法
JP2025134949A Pending JP2025169343A (ja) 2019-10-24 2025-08-14 キメラサイトカイン改変抗体およびその使用方法

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Country Status (7)

Country Link
US (1) US20220380487A1 (https=)
EP (1) EP4048405A2 (https=)
JP (2) JP2022554187A (https=)
CN (1) CN115551594A (https=)
AU (1) AU2020371784A1 (https=)
CA (1) CA3158893A1 (https=)
WO (1) WO2021081440A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
US20250197525A1 (en) * 2021-04-28 2025-06-19 Minotaur Therapeutics, Inc. Humanized chimeric bovine antibodies and methods of use

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JP2015504896A (ja) * 2012-01-09 2015-02-16 ザ・スクリップス・リサーチ・インスティテュート 超長相補性決定領域及びその使用
JP2016527234A (ja) * 2013-07-18 2016-09-08 ファブラス インコーポレイテッド 極めて長い相補性決定領域を有するヒト化抗体
WO2018184964A1 (en) * 2017-04-03 2018-10-11 F. Hoffmann-La Roche Ag Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014524737A (ja) * 2011-06-24 2014-09-25 サイチューン ＩＬ−１５およびＩＬ−１５ＲαＳＵＳＨＩドメインに基づいた免疫サイトカイン
JP2015504896A (ja) * 2012-01-09 2015-02-16 ザ・スクリップス・リサーチ・インスティテュート 超長相補性決定領域及びその使用
JP2016527234A (ja) * 2013-07-18 2016-09-08 ファブラス インコーポレイテッド 極めて長い相補性決定領域を有するヒト化抗体
WO2018184964A1 (en) * 2017-04-03 2018-10-11 F. Hoffmann-La Roche Ag Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15

Also Published As

Publication number Publication date
AU2020371784A1 (en) 2022-06-02
WO2021081440A2 (en) 2021-04-29
JP2025169343A (ja) 2025-11-12
EP4048405A2 (en) 2022-08-31
WO2021081440A3 (en) 2021-05-27
CA3158893A1 (en) 2021-04-29
US20220380487A1 (en) 2022-12-01
CN115551594A (zh) 2022-12-30

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